Surgical navigation system and its construction method for tumor primary lymph nodes in the second near-infrared region

A surgical navigation and near-infrared technology, applied in the field of biofluorescence imaging, can solve the problems of poor stability, low luminous efficiency of probes, limited adjustable wavelength bands, etc., and achieve the effects of good stability, high luminous efficiency, and improved accuracy.
CN111166478BActive Publication Date: 2021-04-27JILIN UNIV FIRST HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JILIN UNIV FIRST HOSPITAL
Publication Date
2021-04-27

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Abstract

The invention discloses a near-infrared second zone tumor primary lymph node surgery navigation system and a construction method thereof. The near infrared second zone tumor primary lymph node surgical navigation system consists of a detection camera, a prism, a filter, an operating table and a laser generator It is constructed, and also includes a composite probe for detection by a detection camera, which is packaged with a cyanine dye and an albumin fragment, or based on a quantum dot with an emission wavelength above 1500 nanometers, using It is wrapped with polyacrylic acid copolymer; the whole navigation system adopts a complete set of equipment, which can achieve the purpose of surgical navigation for wide-field imaging of small animal tumor primary lymph nodes; the fluorescent probe has high luminous efficiency, good stability, and good biocompatibility. It is adjustable in the second infrared region and has clinical transformation value.
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Description

technical field

[0001] The invention relates to bioluminescence imaging technology, in particular to a near-infrared second zone tumor primary lymph node surgical navigation system and a construction method thereof. Background technique

[0002] At present, the development of biological imaging technology gives researchers more abundant means to understand the life process and develop effective medical methods. Among many imaging methods, fluorescence imaging is the most widely used imaging technology among all imaging technologies, which helps researchers use appropriate fluorescent probes to perform targeted imaging of cells, tissues, etc. Traditional fluorescence imaging mainly focuses on visible light (400-700 nm) and near-infrared (700-1000 nm) bands. Due to the influence of tissue autofluorescence and scattering, this band cannot achieve a good penetration depth and Imaging contrast. Therefore, in recent years, people have developed fluorescence imaging technology in...

Claims

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