High-strength magnesium alloy-based degradable bone fracture internal fixation plate and preparation method thereof

Abstract

The invention relates to a high-strength magnesium alloy-based degradable bone fracture internal fixation plate. The plate comprises a magnesium alloy matrix, a magnesium alloy protective surface layer, a magnesium alloy connecting plate and a degradable filling layer, wherein the magnesium alloy protective surface layer is coated outside the magnesium alloy matrix, an outer surface of the magnesium alloy matrix and an inner surface of the magnesium alloy protective surface layer are provided with a bearing cavity, and the degradable filling layer is embedded in holes of the bearing cavity. The preparation method comprises six steps of alloy matrix preparation, material mixing, material filling, forming operation, purification treatment, packaging and storage and the like. On one hand, theplate has good structural strength and toughness and good degradability in a human body, on the other hand, the plate can avoid a phenomenon of deformation of a positioning structure of human bone and insufficient strength of the positioning structure caused by different degradation speeds of different parts, and meanwhile, effectively achieves a purposes of effective anti-inflammatory, anti-infection and nourishment of human wounds, and promotion of improvement of biological activity of human bones and muscle tissues during a degradation process.

Description

technical field [0001] The invention relates to a high-strength magnesium alloy-based degradable internal fixation plate for bone trauma and a preparation method thereof, belonging to the field of medical technology. Background technique [0002] At present, degradable internal fixation plates based on magnesium alloys are widely used in the treatment of fractures and other bone injuries. For example, the patented material with the application number: 201510634440.7 is currently found in the actual use of such patented materials, although it can meet the needs of bones. Strengthening the positioning of the wound site and degrading the material in the body eliminates the need for subsequent surgical removal, but on the one hand, the degradation efficiency of the material degradation site cannot be effectively controlled during the degradation process, so it is very easy to cause the degradation rate of the magnesium alloy material in the human body. Too fast or uneven degrada...

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Problems solved by technology

[0002] At present, degradable internal fixation plates based on magnesium alloys are widely used in the treatment of fractures and other bone injuries. For example, the patented material with the application number: 201510634440.7 is currently found in the actual use of such patented materials, although it can meet the needs of bones. Strengthening the positioning of the wound site and degrading the material in the body eliminates the need for subsequent surgical removal. However, on the one hand, the degradation efficiency of the material degradation site cannot be effectively controlled during the degradation process, so it is easy to cause the degradation rate of the magnesium alloy material in the human body. Too fast or uneven degradation speed will affect the stability and structural strength of the bone positioning structure, and cause the accumulation of magnesium ions, hydrogen gas, local pH value and corrosion deposits in the human body, posing a threat to human health. On the other hand, in the process of degradation, the necessary anti-inflammatory, antibacterial and nourishing wounds cannot be effectively performed on the wound site to promote tissue regeneration, which leads to the phenomenon that the patient's wound site is very prone to infection and the wound recovery speed is slow, which affects the treatment effect and recovery efficiency. In addition, the currently used magnesium alloy fixing plates often adopt a solid plate structure, which also leads to the fact that the magnesium alloy fixing plates often have a large weight, high cost, relatively poor flexibility and residues in the human body. Time is long and insufficient, so in response to this problem, it is urgent to develop a new magnesium alloy positioning plate and its preparation method to meet the needs of actual use

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