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High-porosity polycaprolactone porous microsphere scaffold for bone tissue regeneration and preparation method thereof

A technology for bone tissue regeneration and polycaprolactone, which is used in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve the problems of slow degradation rate, limited application scope, low porosity and low pore size of polycaprolactone porous microspheres , to achieve the effect of large specific surface area, which is conducive to growth

Active Publication Date: 2020-12-08
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, due to the shortcomings of polycaprolactone, such as strong crystallinity and slow degradation rate in vivo, the application range of this material in the biomedical field is limited.
[0004] In the current literature, the porosity and pore size of the prepared polycaprolactone porous microspheres are low, which cannot meet the requirements of an ideal scaffold

Method used

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  • High-porosity polycaprolactone porous microsphere scaffold for bone tissue regeneration and preparation method thereof
  • High-porosity polycaprolactone porous microsphere scaffold for bone tissue regeneration and preparation method thereof
  • High-porosity polycaprolactone porous microsphere scaffold for bone tissue regeneration and preparation method thereof

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Embodiment Construction

[0033] In order to better understand the technical content of the present invention, specific embodiments are given together with the attached drawings for description as follows.

[0034] The polycaprolactone used in the following examples was purchased from Jinan Daigang Bioengineering Co., Ltd., with a relative molecular mass of 60,000-100,000.

[0035] 【preparation】

[0036] The preparation methods of the following examples all adopt the same method to prepare, that is:

[0037] (1) Dissolve polycaprolactone in dichloromethane to prepare a polycaprolactone solution with a concentration of 0.05g / mL, take 10mL as the oil phase; dissolve 4g gelatin in 50mL of 50°C double-distilled water, and pack Refrigerate and solidify at 4°C. When using, melt the gelatin that has been subpackaged and refrigerated in a 37°C water bath, and take a certain amount as the inner water phase;

[0038] (2) Add the internal water phase obtained in step (1) into the oil phase, use a homogenizer to...

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Abstract

The invention discloses a high-porosity polycaprolactone porous microsphere scaffold used for bone tissue regeneration and a preparation method for the high-porosity polycaprolactone porous microsphere scaffold. By taking gelatin as a pore-foaming agent and by taking a multiple emulsion-solvent evaporation method as the basis, polycaprolactone porous microspheres are prepared; pores in surfaces and pores in the high-porosity polycaprolactone porous microspheres communicate with each other; the porosity of the microspheres is 75.28%-90.73%; and the pore size of each pore is 43-217 [mu]m. The polycaprolactone porous microsphere scaffold has high porosity, so that the scaffold can provide more space for growth of bone tissue; meanwhile, space occupied by a polycaprolactone material is also reduced, and the shortcoming of slow degradation of polycaprolactone is remedied; and the porous microspheres have a larger pore size, and are suitable for ingrowth of cells and regeneration of the bonetissue.

Description

technical field [0001] The invention relates to the field of tissue engineering materials, in particular to a high-porosity polycaprolactone porous microsphere scaffold for bone tissue regeneration and a preparation method thereof. Background technique [0002] In bone tissue engineering, scaffolds play a key role. The ideal scaffolds must have the following characteristics: macroscopic structure should be compatible with the shape of the defect; biocompatibility is good, non-toxic, and cells can adhere and grow on the surface. ; Biodegradable, degradation products have no toxic side effects; porosity, so that cells have more space for adhesion and growth, which is conducive to the growth of bone tissue. The interconnected porous structure has many other advantages, such as: increasing the specific surface area, facilitating protein adsorption, and facilitating the removal of metabolic waste, the transport of nutrients, and the transfer of biological factors. [0003] Polyc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/56A61L27/50
CPCA61L27/18A61L27/50A61L27/56A61L2400/12A61L2430/02C08L67/04
Inventor 章非敏刘俊竺鑫晨陈刚
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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