Transposition method of acetophenone isomer

A technology of isomers and acetophenone, which is applied in the field of transposition of acetophenone isomers, can solve the problems of m-dichlorobenzene, such as high price, high specific gravity, and high production cost, and achieve high transposition efficiency, The effect of reducing resource waste and stabilizing performance

Active Publication Date: 2020-06-09
浙江禾本科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the price of m-dichlorobenzene is expensive, and it accounts for a large proportion in production, and the production cost is relatively large

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of transposition method of acetophenone isomer

[0024] Including the following steps:

[0025] Step I, 2,4-dichloroacetophenone synthesis: select m-dichlorobenzene and acetyl chloride raw materials, react to obtain 2,4-dichloroacetophenone crude product; 2,4-dichloroacetophenone crude product, 2 , the content of 4-dichloroacetophenone is 92.5%; the content of 2,6-dichloroacetophenone is 5%;

[0026] Step II, transposition reaction: Add the crude product of 2,4-dichloroacetophenone obtained in step I into cyclohexane with a purity of 99.0%, and then add sulfuric acid with a mass fraction of 98%. Under the condition of reaction for 3 hours, the transposition is completed; wherein, the mass ratio of crude 2,4-dichloroacetophenone, cyclohexane with a purity of 99.0% and sulfuric acid with a mass fraction of 98% is 100:300:11.5.

[0027] In the above, the transposition process of the transposition reaction is:

[0028] In the above, after the transposition is co...

Embodiment 2

[0030] A kind of transposition method of acetophenone isomer

[0031] Including the following steps:

[0032] Step I, 2,4-dichloroacetophenone synthesis: select m-dichlorobenzene and acetyl chloride raw materials, react to obtain 2,4-dichloroacetophenone crude product; 2,4-dichloroacetophenone crude product, 2 , the content of 4-dichloroacetophenone is 94.0%; the content of 2,6-dichloroacetophenone is 5%;

[0033] Step II, transposition reaction: Add the crude product of 2,4-dichloroacetophenone obtained in Step I into cyclohexane with a purity of 99.0%, and then add sulfuric acid with a mass fraction of 98%. The transposition was completed by reacting under the conditions for 5 hours; wherein, the mass ratio of crude 2,4-dichloroacetophenone, cyclohexane with a purity of 99.0% and sulfuric acid with a mass fraction of 98% was 100:300:12.5.

[0034] In the above, the transposition process of the transposition reaction is:

[0035] In the above, after the transposition is ...

Embodiment 3

[0037] A kind of transposition method of acetophenone isomer

[0038] Including the following steps:

[0039] Step I, 2,4-dichloroacetophenone synthesis: select m-dichlorobenzene and acetyl chloride raw materials, react to obtain 2,4-dichloroacetophenone crude product; 2,4-dichloroacetophenone crude product, 2 , the content of 4-dichloroacetophenone is 93.0%; the content of 2,6-dichloroacetophenone is 5%;

[0040] Step II, transposition reaction: Add the crude product of 2,4-dichloroacetophenone obtained in step I into cyclohexane with a purity of 99.0%, and then add sulfuric acid with a mass fraction of 98%, at a temperature of 79°C The reaction was carried out under the conditions for 3.5 hours to complete the transposition; wherein, the mass ratio of crude 2,4-dichloroacetophenone, cyclohexane with a purity of 99.0% and sulfuric acid with a mass fraction of 98% was 100:300:11.8.

[0041] In the above, the transposition process of the transposition reaction is:

[0042]...

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Abstract

The invention discloses a transposition method of an acetophenone isomer, and the transposition method of an acetophenone isomer comprises 2, 4-dichloroacetophenone synthesis and transposition reactions. According to the transposition method of an acetophenone isomer, a 2, 6-dichloroacetophenone isomer in crude 2, 4-dichloroacetophenone can be converted into 2, 4-dichloroacetophenone through a transposition reaction, so that the content of the 2, 6-dichloroacetophenone isomer in the crude 2, 4-dichloroacetophenone is reduced, the yield of the 2, 4-dichloroacetophenone is increased, the purification of the crude 2, 4-dichloroacetophenone is realized, the reaction is simple, and the transposition efficiency is high.

Description

technical field [0001] The invention relates to the technical field of acetophenone purification, in particular to a method for transposition of acetophenone isomers. Background technique [0002] 2,4-Dichloroacetophenone is the raw material for the preparation of ω-bromo-2,4-dichloroacetophenone or ω-2,4-trichloroacetophenone, the latter two are used for the preparation of imazalil and propane It is the intermediate of fungicides such as azole and etoconazole, and it is also the intermediate of insecticide chlorpyramid and herbicide wild swallow. [0003] The main raw material for the synthesis of 2,4-dichloroacetophenone is m-dichlorobenzene. However, the price of m-dichlorobenzene is expensive, and it accounts for a large proportion in production, and the production cost is relatively high. At the same time, in the synthesis process of 2,4-dichloroacetophenone, the content of 2,4-dichloroacetophenone in the product is relatively low, containing more 2,6-dichloroacetophe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/67C07C45/45C07C49/807
CPCC07C45/67C07C45/455C07C49/807
Inventor 赵振东徐瑶王进曾挺潘光飞
Owner 浙江禾本科技股份有限公司
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