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Method for recycling sodium phenylacetate

A technology of sodium phenylacetate and membrane dialysate, which is applied in the field of medicine, can solve the problems of increased waste water discharge, increased pressure on environmental protection, and difficulty in treating waste water, and achieves reduced waste water discharge, small environmental impact, and low production costs. Effect

Inactive Publication Date: 2020-06-19
UNITED LAB INNER MONGOLIA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned recovery methods are all acidification crystallization processes. In the acidification crystallization, since a large amount of acid and alkali are added to adjust the pH, and the residual phenylacetic acid in the crystallization mother liquor is relatively high, a macroporous resin needs to be used for adsorption, resulting in high cost in the recovery process. Wastewater The discharge volume increases, and the subsequent treatment of wastewater is difficult, increasing the pressure on environmental protection

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0043] This example provides a method for recycling sodium phenylacetate. Take 300L of 6-APA cracking solution, distill the deesterified alcohol to less than 1000ppm under reduced pressure, add 3kg of activated carbon for decolorization, the temperature is 40°C, and it takes 60min. After filtering the activated carbon, put it into 1m 3Concentrate to 207mg / ml in a jacketed evaporator. After cooling down to 40°C, the ultrafiltration membrane was used to remove impurities and decolorize to obtain a dialysate concentration of 139.4mg / ml, a concentrated solution of sodium phenylacetate content of 0.3mg / ml, a recovery rate of 99.8%, and a purity of 98.77%.

Embodiment 2

[0045] This example provides a method for recycling sodium phenylacetate. Take 300L of 6-APA lysate, distill the deesterified alcohol to less than 1000ppm under reduced pressure, add 2kg of activated carbon for decolorization, the temperature is 40°C, and it takes 50min. After filtering the activated carbon, put it into 1m 3 Concentrate to 241.8mg / ml in a jacketed evaporator. After cooling down to 40°C, the ultrafiltration membrane was used to remove impurities and decolorize to obtain a dialysate concentration of 196.9 mg / ml, a concentrated solution of sodium phenylacetate content of 24.4 mg / ml, a recovery rate of 99%, and a purity of 98.61%.

Embodiment 3

[0047] This embodiment provides a method for recycling sodium phenylacetate. Take 300L of 6-APA lysate, distill the deesterified alcohol to less than 1000ppm under reduced pressure, add 1.5kg of activated carbon for decolorization, the temperature is 40°C, and it takes 40min. The filter membrane was used to remove impurities and decolorize, and the concentration of the decolorized solution was 151.6mg / ml, and the content of sodium phenylacetate in the concentrated solution was 9.1mg / ml; the dialysate was put into 1m 3 Concentrate to 337mg / ml in a jacketed evaporator. The recovery rate is 98.62%, and the purity is 97.97%.

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Abstract

The invention provides a method for recycling sodium phenylacetate. The method comprises the following steps: acidifying a pyrolysis waste liquid for producing 6-APA, carrying out extracting with an organic solution, alkalifying an extracted organic phase with liquid caustic soda, separating a water phase, and allowing a separated water phase into a rectifying tower to remove residual organic matters; and carrying out decoloration through active carbon, removing impurities through an ultrafiltration membrane, and carrying out evaporation and concentration so as to obtain a sodium phenylacetatesolution with a concentration of more than 25%. According to the invention, through improvement of the prior art, the method provided by the invention has the following advantages: the purity and yield of a recovered sodium phenylacetate product are improved; the production cost is reduced; the problems of high acidification crystallization cost, a plurality of related hazardous chemicals and thelike in a conventional process are solved; meanwhile, the problems of heavy wastewater discharge and difficulty in treating a waste liquid in an original process are effectively solved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for recycling sodium phenylacetate. Background technique [0002] Sodium phenylacetate is colorless, odorless, and has low solubility. When there is less water and the temperature is lower, it will appear layered and agglomerated. When the pH is less than 6, it will form phenylacetic acid, which is mainly used to manufacture penicillin. 6-APA (6-aminopenicillanic acid), as the mother nucleus of semi-synthetic penicillin, will produce a large amount of by-product sodium phenylacetate during the production process. At present, the recovery of waste sodium phenylacetate in the production of 6-APA is mainly based on acidification crystallization. [0003] Chinese Patent Publication No. CN106083571 A, the name of the invention is "a method for secondary recovery and purification of phenylacetic acid from 6-APA lysate", which discloses acidifying the 6-APA lysate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/44C07C51/47C07C51/42C07C57/32
CPCC07C51/42C07C51/44C07C51/47C07C57/32
Inventor 花远志郝喜升任旭光张勇
Owner UNITED LAB INNER MONGOLIA CO LTD
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