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Application of conjugated linoleic acid glyceride in preparing product for treating high fat diet induced non-alcoholic fatty liver diseases

A technology of conjugated linoleic acid glycerides and conjugated linoleic acid glycerides, applied in the field of application of conjugated linoleic acid glycerides in the preparation of products for the treatment of non-alcoholic fatty liver induced by high-fat diets, can solve the problem of The high price of raw materials and other issues, to achieve the effect of easy access, good effect, and good effect

Inactive Publication Date: 2020-06-30
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN102755350 describes a method for refining seal oil. The obtained product has a good effect on alleviating non-alcoholic fatty liver, but the price of raw materials is high, and there are also limitations in use

Method used

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  • Application of conjugated linoleic acid glyceride in preparing product for treating high fat diet induced non-alcoholic fatty liver diseases
  • Application of conjugated linoleic acid glyceride in preparing product for treating high fat diet induced non-alcoholic fatty liver diseases
  • Application of conjugated linoleic acid glyceride in preparing product for treating high fat diet induced non-alcoholic fatty liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1: Effect of CLA-TG on body weight, body weight gain, fat body ratio and food intake of HFD-induced non-alcoholic fatty liver rats

[0047] (1) Experimental materials

[0048] (1) Experimental animals:

[0049] Strain: SD rat, male, SPF grade;

[0050] Source: Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.;

[0051] License number: SCXK (Beijing) 2016-0006, laboratory animal quality certificate number: No.1100111911028450

[0052] Weight: 160-180g

[0053] Number of animals per group: 10

[0054] Test substance: CLA-TG and CLA-TG microcapsule powder

[0055] (2) Experimental method

[0056] The SD rats were randomly divided into 4 groups according to body weight, namely blank control group, high-fat diet group, CLA-TG group and CLA-TG microcapsule powder group. Among them, the blank control group was fed with basal feed; the rest of the groups were fed with high-fat feed, and gavaged according to group requirements.

[0057] The experimen...

Embodiment 2

[0062] Example 2: Effect of CLA-TG on Blood Biochemical Indexes of HFD-Induced Nonalcoholic Fatty Liver Rats

[0063] (1) Experimental materials

[0064] Blood samples from rats fed in different ways in Example 1, alanine aminotransferase and aspartate aminotransferase detection kits were purchased from Nanjing Jiancheng Biological Co., Ltd.

[0065] (2) Experimental method

[0066] After the obtained blood sample was left to stand for 15 minutes, it was centrifuged at 3000 r / min for 10 minutes to obtain a serum sample. 20 μl of serum samples were taken and tested according to the operating instructions of the alanine aminotransferase and aspartate aminotransferase kits of Nanjing Jiancheng Biological Co., Ltd. respectively.

[0067] (3) Experimental results

[0068] Such as figure 2 As shown in A-B, ALT and AST of mice fed with high-fat diet were significantly increased compared with those fed with basic diet (P<0.001), and CLA-TG group and CLA-TG microcapsule powder gro...

Embodiment 3

[0069] Example 3: Effect of CLA-TG on liver triglyceride content of HFD-induced non-alcoholic fatty liver rats

[0070] (1) Experimental materials

[0071] Rat liver samples from Example 1 fed in different ways, triglyceride kit purchased from Nanjing Jiancheng Biological Co., Ltd.

[0072] (2) Experimental method

[0073] About 50 mg of liver tissue was taken to prepare 10% liver homogenate. The test was carried out according to the operation manual of the triglyceride detection kit of Nanjing Jiancheng Biological Co., Ltd.

[0074] (3) Experimental results

[0075] Such as image 3 As shown, the liver triglyceride level of rats fed with high-fat diet was significantly higher than that of the basal feed group (P<0.001). Down-regulation (P<0.05), it proved that CLA-TG can reduce the liver triglyceride content of HFD-induced non-alcoholic fatty liver rats, and the CLA-TG microcapsule powder group decreased slightly more than the CLA-TG group.

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Abstract

The invention relates to application of conjugated linoleic acid glyceride and microcapsule powder thereof in preparing foods or medicines for preventing and treating high fat diet induced non-alcoholic fatty liver diseases. The invention discloses application of the conjugated linoleic acid glyceride or the microcapsule powder of the conjugated linoleic acid glyceride in preparing foods, healthcare products or medicines for preventing, relieving and treating high fat diet induced non-alcoholic fatty liver diseases. According to the application, CLA-TG (conjugated linoleic acid-triglyceride) is adopted to prevent and relieve non-alcoholic fatty liver diseases, and an animal disease model involved in the application is an HFD (high fat diet) induced non-alcoholic fatty liver disease model.The application has the effect characteristics that weights and fat to weight ratios are reduced, contents of blood ALT (alanine transaminase), AST (aspartate transaminase) and liver TG are reduced, and a liver lipid droplet accumulation phenomenon can be alleviated; and the application is good in effect, high in security and easy in product obtaining.

Description

technical field [0001] The invention relates to the preparation of a conjugated linoleic acid glyceride and the application of the microcapsule powder in the preparation of food or medicine for the prevention and treatment of non-alcoholic fatty liver induced by high-fat diet. Background technique [0002] With the progress of society and the improvement of living standards, the national dietary structure is gradually unbalanced. Extensive intake of high-fat foods has caused a variety of metabolic diseases, which are seriously threatening the health of Chinese people. Among them, fatty liver disease has become a recent research hotspot due to its high incidence and younger age. Fatty liver disease can be divided into alcoholic fatty liver disease and non-alcoholic fatty liver disease. Among them, non-alcoholic fatty liver disease (NAFLD) is a liver metabolic disease with the highest incidence rate in the world, and its pathogenesis is complicated. Resistance first leads t...

Claims

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Application Information

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IPC IPC(8): A61K31/232A61K9/50A61P3/06A61P1/16A23L33/115A23C9/152A21D13/068
CPCA61K31/232A61K9/50A61K9/5089A61P3/06A61P1/16A23L33/115A23C9/1528A21D13/068A23V2002/00
Inventor 石超文瑾范超夏俪宁吴文忠
Owner INNOBIO CORP LTD
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