The invention discloses a preparation method of an apple mulberry leaf beverage capable of reducing blood sugar, losing weight and expelling toxins. The method comprises the following steps: blanchingmulberry leaves in boiling water for 8-20min, fishing out the mulberry leaves, conducting washing, sun drying and grinding, putting the mulberry leaves into a pot, conducting stir-frying with slow fire until cooked and fragrant, adding granulated sugar and seasonings, conducting uniform stirring, adding water, conducting uniform stirring, and conducting heating, heat insulation and centrifugal filtration to obtain a mulberry liquid; removing impurities of apples, washing the apples, soaking the apples in clear water, fishing out the apples, putting the apples into a steamer, conducting steaming until fully cooked, and grinding the cooked apples into powder to obtain apple powder; and mixing the mulberry liquid with the apple powder, then adding a proper amount of purified water, then conducting heating homogenization and filtration, taking filtrate, heating the filtrate to 70-90 DEG C, and conducting sterilization. The beverage of the invention is scientific and reasonable in processand comprehensive and balanced in nutrients, can be taken for a long time, does not affect the normal food intake of human body, has the efficacy of being sweet and delicious, reducing weight, relaxing bowels, expelling toxins, refreshing mind, clearing the liver, improving eyesight, reducing blood fat, reducing blood pressure and reducing blood sugar, has no toxic or side effect, and has obvioushealth-care efficacy on diseases such as obesity, hyperlipidemia and hyperglycemia.