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Health care food composition capable of increasing bone mass, and application of health care food composition

A technology of health food and composition, applied in application, drug combination, food ingredients and other directions, can solve the problems of low content of active ingredients and unsatisfactory actual effect, etc., to promote differentiation and development, increase bone mass, and promote the expression of osteogenic genes Effect

Pending Publication Date: 2020-07-03
浙江欧谱生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because blueberries are eaten directly, their active ingredient content is low, resulting in unsatisfactory actual effects.

Method used

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  • Health care food composition capable of increasing bone mass, and application of health care food composition
  • Health care food composition capable of increasing bone mass, and application of health care food composition
  • Health care food composition capable of increasing bone mass, and application of health care food composition

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Experimental program
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Effect test

Embodiment 1

[0023] Sepp-pak C18 SPE (Waters, Pittsburgh, PA, USA) volumetric tube was used to treat the control group or 10% BB-fed rat serum: the volumetric tube was washed with 3mL methanol, and then balanced with 3mL 0.2% formic acid aqueous solution. Fill the volumetric tube with serum (500 mL). The volumetric tube was rinsed with 3 mL of 0.2% formic acid aqueous solution, and the total phenolic acid was recovered with a 0.2% formic acid-methanol mixed solution. Methanol solution in N 2 Dried under the conditions of, and then dissolved in 200mL 0.2% formic acid-methanol solution for phenolic acid analysis. The Agilent 1100 high performance liquid chromatography system (Agilent Technologies, Santa Clara, CA, USA) and 4000Q TRAP mass spectrometer (Applied Biosystems) were used to characterize and quantify phenolic acids according to the method described above. The study found that the concentration of 7 kinds of phenolic acids in their free form is 6 to 10 times that of the control grou...

Embodiment 2

[0025] The artificial mixture of these phenolic acids was used to treat ST2 cells at the same concentration as the serum concentration of rats on the same BB diet. Compared with control rat cells, the expression of osteoblast formation markers ALP and OCN in serum containing the same concentration of phenolic acid mixture were significantly up-regulated, and Runx2 and b-catenin mRNA were also significantly up-regulated after mixing (p figure 2 ). ST2 and neonatal rat skull cell culture, phenolic acid stimulated osteoblast differentiation (p image 3 ). In summary, at least to a certain extent, the high bone mass of rats fed on the BB diet may be due to the high serum phenolic acid concentration. These phenolic acids come from the polyphenols in the BB diet and are produced under the metabolism of intestinal bacteria or during the first metabolism of the intestinal mucosa or liver.

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Abstract

The invention discloses a health care food composition capable of increasing a bone mass, and can accelerate osteoblast to carry out differentiation and development. The effective ingredients of the health care food composition are seven phenolic acids extracted from serums after an animal eats Vaccinium Spp. Researches indicate that the dosage of the seven phenolic acids are certain, can accelerate osteogenesis gene expression, can accelerate osteogenesis gene development and can increase the bone mass.

Description

Technical field [0001] The patent belongs to the field of health food, and specifically relates to a health food composition for increasing bone mass and its application. Background technique [0002] With the aging of the social population, the incidence of osteoporosis and osteoporotic fractures continues to rise. Research shows that in 2016, the prevalence of osteoporosis in the elderly over 60 years old in China was 36%, of which 23% were men and 49% were women, indicating that osteoporosis has become an important public health problem facing my country. The most serious consequence of osteoporosis is osteoporotic fracture, which in turn causes a series of health problems such as life difficulties and death. According to forecasts by authoritative institutions, by 2050, the number of patients suffering from osteoporotic fractures in my country will reach 5.99 million, and the corresponding medical expenditure will be as high as 174.5 billion yuan. The early prevention and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A61K36/45A61P19/10
CPCA23L33/10A61K36/45A61P19/10A23V2002/00A23V2200/306A23V2250/204
Inventor 陈尽染
Owner 浙江欧谱生物科技有限公司
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