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Composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, and preparation method and application of composite material

A near-infrared light and composite material technology, applied in the field of composite materials, can solve the problems affecting the efficiency of PDT, slow space transfer, accurate matching of oxygen and photosensitizers, etc., and achieve the effect of improving treatment efficiency.

Active Publication Date: 2020-07-14
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims to solve the technical problems in the prior art that the oxygen production method in the photodynamic therapy of tumors cannot realize the precise matching of oxygen and photosensitizer in space and time at the same time, and the rapid oxygen consumption and slow spatial transfer greatly affect the PDT efficiency. Provide a composite material for simultaneous generation of oxygen and active oxygen under near-infrared light excitation, its preparation method and application

Method used

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  • Composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, and preparation method and application of composite material
  • Composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, and preparation method and application of composite material
  • Composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, and preparation method and application of composite material

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preparation example Construction

[0033] The invention provides a method for preparing a composite material for simultaneous generation of oxygen and active oxygen under near-infrared light excitation, comprising the following steps:

[0034] Step 1, preparation of up-conversion nanoparticles

[0035] Upconverting nanoparticles are prepared by the following method:

[0036] Weigh 1mM rare earth acetate, wherein Y:Yb:Er=78:20:20, and 10mM sodium fluoride, and add them to a three-necked flask containing 10mL oleylamine and 10mL octadecene, continue to feed nitrogen and heat Keep at 120°C for 1 hour; then slowly heat up to 320°C and stir for 1 hour, then cool down to room temperature naturally; add absolute ethanol, centrifuge to obtain a precipitate, wash with water and ethanol three times, and finally obtain upconverting nanoparticles, which are dispersed in in chloroform; finally, 1 mL of 0.1M hexadecyltrimethyl bromide solution was added to the chloroform solution of upconverting nanoparticles, stirred at 70...

Embodiment 1

[0045] The preparation of the composite material used for simultaneous generation of oxygen and active oxygen under the excitation of near-infrared light provided by the present invention, the specific steps are as follows:

[0046] 1. Synthesis of upconversion nanoparticles:

[0047] Weigh 1mM rare earth acetate (wherein Y:Yb:Er=78:20:20) and 10mM sodium fluoride into a three-necked flask containing 10mL oleylamine and 10mL octadecene, continue to feed nitrogen and heat To 120 ℃, keep 1h. Then it was heated slowly to 320° C. and stirred for 1 h, and then cooled to room temperature naturally. Add absolute ethanol, centrifuge to obtain a precipitate, wash with water and ethanol three times, and finally obtain upconversion nanoparticles, which are dispersed in chloroform. Finally, 1 mL of hexadecyltrimethyl bromide solution (0.1 M) was added to the chloroform solution of upconverting nanoparticles, stirred at 70° C. for 4 hours, centrifuged, washed with water, and dried to obt...

Embodiment 2

[0073] Synthesis of upconverting nanomaterials and thylakoid membrane composites with an excitation wavelength of 808 nm.

[0074] 1. Synthesis of upconversion nanoparticles:

[0075] Weigh 0.1mM rare earth acetate (wherein Y:Yb:Er:Nd=38:10:1:1) and 10mM sodium fluoride into a three-necked flask containing 10mL oleylamine and 10mL octadecene, and keep Bubble nitrogen and heat to 120°C for 1h. Then it was heated slowly to 340° C. and stirred for 1 h, and then cooled to room temperature naturally. Add absolute ethanol, centrifuge to obtain a precipitate, wash with water and ethanol three times, and finally obtain upconversion nanoparticles, which are dispersed in chloroform. Finally, 1 mL of hexadecyltrimethyl bromide solution (0.1 M) was added to the chloroform solution of upconverting nanoparticles, stirred at 70° C. for 4 hours, centrifuged, washed with water, and dried to obtain aqueous phase upconverting nanoparticles.

[0076] 2. Extraction of thylakoid membrane:

[00...

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Abstract

The invention relates to a composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, and a preparation method and application of the composite material, and belongs to the technical field of composite materials. The technical problem that an oxygen generation manner during the tumor photodynamic therapy in the prior art cannot simultaneously realize the precise matching of oxygen and a photosensitizer both in space and time, and the PDT efficiency is greatly affected due to rapid oxygen consumption and slow spatial transmission is solved. The composite material of the invention is composed of up-conversion nanoparticles and thylakoid membranes. The invention also provides a preparation method and application of the composite material. The up-conversion nanomaterial in the composite material of the invention can convert near-infrared light (808-980 nm) into red light (-660 nm), the red light is used to excite a light system I and a light system II in the thylakoid membranes, photo-generated holes generated by the light system I are used to react with water to generate oxygen, the light systems I and II transfer energy to oxygen molecules to generate singlet oxygen, and thereby the tumor photodynamic therapy efficiency is improved.

Description

technical field [0001] The invention relates to a composite material, in particular to a composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, a preparation method and application thereof. Background technique [0002] Photodynamic therapy (PDT), as a non-invasive medical technology, has the advantages of low toxicity, small side effects, broad-spectrum anti-cancer, and high targeting compared with conventional treatments such as surgery, chemotherapy, and radiotherapy. However, due to the rapid proliferation of tumor cells, incomplete vascular development and uneven distribution, it is easy to cause insufficient supply of internal oxygen and other substances, forming a hypoxic state, which greatly limits the production of reactive oxygen species (Reactive oxygen species, ROS) during PDT. , reducing the PDT efficiency. The current oxygen production method cannot realize the precise matching of oxygen and photosensiti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0057A61K41/0071A61P35/00
Inventor 张海元程岩郑润晓吴夏青宋盼盼王妍婧
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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