Composite material for simultaneous generation of oxygen and active oxygen under near-infrared light excitation, preparation method and application thereof

A near-infrared light and composite material technology, applied in the field of composite materials, can solve the problems affecting PDT efficiency, accurate matching of oxygen and photosensitizers, slow space transfer, etc., to achieve the effect of improving treatment efficiency

Active Publication Date: 2021-07-30
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims to solve the technical problems in the prior art that the oxygen production method in the photodynamic therapy of tumors cannot realize the precise matching of oxygen and photosensitizer in space and time at the same time, and the rapid oxygen consumption and slow spatial transfer greatly affect the PDT efficiency. Provide a composite material for simultaneous generation of oxygen and active oxygen under near-infrared light excitation, its preparation method and application

Method used

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  • Composite material for simultaneous generation of oxygen and active oxygen under near-infrared light excitation, preparation method and application thereof
  • Composite material for simultaneous generation of oxygen and active oxygen under near-infrared light excitation, preparation method and application thereof
  • Composite material for simultaneous generation of oxygen and active oxygen under near-infrared light excitation, preparation method and application thereof

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preparation example Construction

[0033] The invention provides a preparation method of a composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, comprising the following steps:

[0034] Step 1. Preparation of Upconversion Nanoparticles

[0035] Upconversion nanoparticles are prepared by the following methods:

[0036] Weigh 1mM rare earth acetate, wherein Y:Yb:Er=78:20:20, and 10mM sodium fluoride into a three-necked flask containing 10mL oleylamine and 10mL octadecene, continue to pass nitrogen and heat to 120 °C for 1 h; then slowly heated to 320 °C and stirred for 1 h, naturally cooled to room temperature; added absolute ethanol, centrifuged to obtain a precipitate, washed with water and ethanol three times each, and finally obtained up-conversion nanoparticles, dispersed in chloroform; finally, 1 mL of 0.1M cetyltrimethyl bromide solution was added to the chloroform solution of upconversion nanoparticles, stirred at 70° C. for 4 hours, centrifuged, ...

Embodiment 1

[0045] The preparation of the composite material used for simultaneous generation of oxygen and active oxygen under the excitation of near-infrared light provided by the present invention, the specific steps are as follows:

[0046] 1. Synthesis of upconversion nanoparticles:

[0047] Weigh 1mM rare earth acetate (wherein Y:Yb:Er=78:20:20) and 10mM sodium fluoride into a three-necked flask containing 10mL oleylamine and 10mL octadecene, continue to feed nitrogen and heat To 120 ℃, keep 1h. Then it was heated slowly to 320° C. and stirred for 1 h, and then cooled to room temperature naturally. Add absolute ethanol, centrifuge to obtain a precipitate, wash with water and ethanol three times, and finally obtain upconversion nanoparticles, which are dispersed in chloroform. Finally, 1 mL of hexadecyltrimethyl bromide solution (0.1 M) was added to the chloroform solution of upconverting nanoparticles, stirred at 70° C. for 4 hours, centrifuged, washed with water, and dried to obt...

Embodiment 2

[0073] Synthesis of upconverting nanomaterials and thylakoid membrane composites with an excitation wavelength of 808 nm.

[0074] 1. Synthesis of upconversion nanoparticles:

[0075] Weigh 0.1mM rare earth acetate (wherein Y:Yb:Er:Nd=38:10:1:1) and 10mM sodium fluoride into a three-necked flask containing 10mL oleylamine and 10mL octadecene, and keep Bubble nitrogen and heat to 120°C for 1h. Then it was heated slowly to 340° C. and stirred for 1 h, and then cooled to room temperature naturally. Add absolute ethanol, centrifuge to obtain a precipitate, wash with water and ethanol three times, and finally obtain upconversion nanoparticles, which are dispersed in chloroform. Finally, 1 mL of hexadecyltrimethyl bromide solution (0.1 M) was added to the chloroform solution of upconverting nanoparticles, stirred at 70° C. for 4 hours, centrifuged, washed with water, and dried to obtain aqueous phase upconverting nanoparticles.

[0076] 2. Extraction of thylakoid membrane:

[00...

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Abstract

The invention relates to a composite material for simultaneously generating oxygen and active oxygen under near-infrared light excitation, a preparation method and application thereof, and belongs to the technical field of composite materials. Solve the technical problems in the prior art that the oxygen production method in the photodynamic therapy of tumors cannot realize the precise matching of oxygen and photosensitizer in space and time at the same time, and the rapid oxygen consumption and slow space transfer greatly affect the PDT efficiency. The composite material of the invention is composed of up-converting nanoparticles and thylakoid membranes. The invention also provides the preparation method and application of the composite material. The composite material of the present invention can convert near-infrared light (808-980nm) into red light (~660nm) in the mid-up conversion nanomaterial, which is used to excite photosystem I and photosystem II in thylakoid membranes, and photosystem I produces Photogenerated holes are used to react with water to generate oxygen, and photosystems I and II transfer energy to oxygen molecules and generate singlet oxygen, thereby improving the efficiency of tumor photodynamic therapy.

Description

technical field [0001] The invention relates to a composite material, in particular to a composite material for generating oxygen and active oxygen simultaneously under near-infrared light excitation, and a preparation method and application thereof. Background technique [0002] Photodynamic therapy (PDT), as a non-invasive medical technology, has the advantages of low toxicity, less side effects, broad-spectrum anti-cancer, and higher targeting than conventional treatments such as surgery, chemotherapy, and radiotherapy. However, due to the rapid proliferation of tumor cells, incomplete vascular development and uneven distribution, it is easy to lead to insufficient supply of internal oxygen, resulting in a hypoxic state, which greatly limits the production of reactive oxygen species (ROS) during PDT. , reducing the PDT efficiency. The current oxygen production methods cannot achieve accurate matching of oxygen and photosensitizers in space and time at the same time. The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0057A61K41/0071A61P35/00
Inventor 张海元程岩郑润晓吴夏青宋盼盼王妍婧
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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