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Application of stable rice sugar derivative-treated by enzyme

A technology of enzyme treatment and derivatives, applied in the field of controlling mammalian serum glucose level, can solve problems such as variable and large fluctuations in blood sugar level

Inactive Publication Date: 2003-07-16
THE RICEX CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, blood sugar levels can still fluctuate (sometimes dramatically) in patients treated with insulin or diet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] This example illustrates the clinical evaluation of stable rice bran derivatives in diabetic patients. Furthermore, the effects of RiceX stabilized rice bran, RiceX Ricelin (a stabilized soluble derivative of rice bran) and RiceX fiber complex (a stabilized insoluble derivative of rice bran) in diabetic (type I) and non-insulin-dependent diabetic (type II) humans were evaluated. Effects of Subject Blood Glucose and Lipids. This clinical evaluation was performed at the Center for Advanced Medical Research in Madison, Wisconsin, and the Army Pathology Research Institute, Rawalpindi, Pakistan.

[0079] Materials and methods

[0080] A. Product description

[0081] RiceX Stabilized Rice Bran, RiceX Ricelin and RiceX Fiber Complex are rich in fiber, non-starch polysaccharides, complex carbohydrates, protein, fat, B complex vitamins and strong antioxidants such as beta-carotene, vitamin E (tocopherol and Tocotrienols), gamma-oryzanol, phytosterols and polyphenols.

[00...

Embodiment 2

[0119] This example illustrates the synthesis of enzyme-treated stabilized rice bran.

[0120] 1200 lbs of stabilized rice bran were mixed with 570 gallons of water to form an aqueous extract. The mixture was stirred for 30 minutes. Add 240 grams of alpha-amylase and mix for 10 minutes. The mixture was then pumped through a heat exchanger at about 190°F and passed through the coils for 25 minutes. The mixture was then dried on a drum dryer to less than 5% moisture.

Embodiment 3

[0122] This example illustrates the synthesis of enzyme-treated stable insoluble and soluble derivatives of rice bran.

[0123] 1200 lbs of stabilized rice bran were mixed with 570 gallons of water to form an aqueous extract. The mixture was stirred for 30 minutes. Add 240 grams of alpha-amylase to the mixture and mix for 10 minutes.

[0124] The mixture was then pumped through a heat exchanger at about 190°F and passed through the coils for 25 minutes. The mixture was then pumped into a decanter centrifuge set at 3,6000 RPM and fed at a rate of 2 gallons per minute. In a centrifuge, the soluble part of the rice bran is separated from the insoluble part.

[0125] The soluble fraction was dried on a drum dryer to a moisture of 2.8%. The insoluble fraction was also dried on a drum dryer to a moisture of 4%. The process yielded 550 lbs of dry rice bran insoluble and 420 lbs of dry rice bran soluble concentrate. The chemical compositions of the two products are listed in Tab...

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PUM

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Abstract

Methods for controlling serum glucose level in a mammal comprising ingesting a stabilized rice bran derivative selected from the group consisting of a solubilized fraction, an insolubilized fraction, an enzyme treated stabilized rice bran and mixtures thereof, thereby reducing serum glucose level in said mammal.

Description

[0001] related application [0002] This application is related to US Patent Application No. 60 / 057.409, filed August 29, 1997, the contents of which are incorporated herein by reference. field of invention [0003] The present invention relates to methods of controlling serum glucose levels in mammals. background of the invention [0004] Diabetes is an incurable chronic disease. It affects 16 million Americans and more than 125 million people around the world. Diabetes is the fourth leading cause of death in the United States. In 1997, 178,000 people died from the disease and its related complications. [0005] Diabetes mellitus is characterized by impaired ability to metabolize carbohydrates, elevated blood glucose and excretion of glucose in urine. This defect involves interference with insulin's ability to promote the uptake of glucose by cells to release energy in the form of ATP. [0006] In people with diabetes, the pancreas produces insufficient or no insulin, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A21D2/36A23L1/308A23L7/10A61P3/10
CPCY10S514/866A23V2002/00A23L1/3081A61K36/899A21D2/36A23L1/1016A23L7/115A23L33/22A61P3/06A61P3/08A61P3/10A23V2250/5106A61K2300/00
Inventor P·麦克皮克R·切尔瓦涅库R·S·V·凯鲁克
Owner THE RICEX CO INC