Biodegradable material and preparation method and application thereof

A degradable material and biological technology, applied in medical science, prosthesis, etc., can solve the problems of self-healing effect and poor tensile strength, and achieve good healing effect, simple and easy reaction process, and good stretching effect. Effect

Pending Publication Date: 2020-07-28
荆门市诺维英新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the object of the present invention is to provide a biodegradable material. In order to solve the problems of poor self-healing effect and tensile strength in existing biodegradable materials,

Method used

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  • Biodegradable material and preparation method and application thereof
  • Biodegradable material and preparation method and application thereof
  • Biodegradable material and preparation method and application thereof

Examples

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preparation example Construction

[0024] The embodiment of the present invention also provides the preparation method of the above-mentioned biodegradable material, the method comprising the following steps:

[0025] Step 1, adding α-hydroxy acid to sodium polyphosphate, fully stirring and reacting to obtain a mixed solution;

[0026] Step 2, adding RAPA and malic acid to the mixed solution obtained in step 1, fully stirring and reacting to obtain a mixed fluid;

[0027] In step 3, the mixed fluid obtained in step 2 is washed with absolute ethanol and freeze-dried to obtain a biodegradable material.

[0028] Further, in step 1, the reaction temperature is 20-40°C, and the reaction time is 6-8d.

[0029] Further, in step 2, the reaction temperature is 20-40°C, and the reaction time is 2-3d.

[0030] The present invention prepares a fully degradable polymer with good healing effect and good stretching effect by blending α-hydroxy acid, sodium polyphosphate malate and rigid polymer RAPA in a certain proportion ...

Embodiment 1

[0032] This embodiment provides a biodegradable material, including polylactic acid, malic acid, sodium polyphosphate, and RAPA;

[0033] Among them, the corresponding polymer monomer molar ratio of polylactic acid and sodium polyphosphate is 1:0.5; the mass ratio of polylactic acid, malic acid, and RAPA is 700:8:1.5;

[0034] The above-mentioned biodegradable materials are specifically prepared by the following method:

[0035] Step 1, adding polylactic acid to sodium polyphosphate, fully stirring and reacting at 20-40°C for 6-8 hours to obtain a mixed solution;

[0036] Step 2, adding RAPA and malic acid to the mixed solution obtained in step 1, adding to the reaction solution obtained in step 1, fully stirring and reacting at 20-40°C for 2-3 hours to obtain a mixed fluid;

[0037] In step 3, the mixed fluid obtained in step 2 is washed with absolute ethanol and freeze-dried to obtain a biodegradable material.

Embodiment 2

[0039] This embodiment provides a biodegradable material prepared from polylactic acid, malic acid, sodium polyphosphate, and RAPA;

[0040] Among them, the corresponding polymer monomer molar ratio of polylactic acid and sodium polyphosphate is 1:1; the mass ratio of polylactic acid, malic acid, and RAPA is 600:5:1;

[0041] The above-mentioned biodegradable materials are specifically prepared by the following method:

[0042] Step 1, adding polylactic acid to sodium polyphosphate, fully stirring and reacting at 20-40°C for 6-8 hours to obtain a mixed solution;

[0043] Step 2, adding RAPA and malic acid to the mixed solution obtained in step 1, adding to the reaction solution obtained in step 1, fully stirring and reacting at 20-40°C for 2-3 hours to obtain a mixed fluid;

[0044] In step 3, the mixed fluid obtained in step 2 is washed with absolute ethanol and freeze-dried to obtain a biodegradable material.

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Abstract

The invention discloses a biodegradable material. The biodegradable material is prepared from alpha-hydroxy acid, malic acid, sodium polyphosphate and RAPA, wherein the molar ratio of the corresponding polymer monomers of the alpha-hydroxy acid to the sodium polyphosphate is 1: (1-0.01), and the mass ratio of the alpha-hydroxy acid to the malic acid to the RAPA is (600-800): (5-10): (1-2). The invention also discloses a preparation method of the biodegradable material. By blending alpha-hydroxy acid, sodium malate polyphosphate and a rigid polymer RAPA in a certain proportional range to carryout a polymerization reaction, the fully-degradable polymer material with a good healing effect and an excellent stretching effect is prepared, and the biodegradable material can be applied to raw microcapsules, liquid core fibers and simulated human capillary clusters, and has a great application prospect in the aspects of biomimetic materials, drug release or human tissue substitute materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a biodegradable material and its preparation method and application. Background technique [0002] Biodegradable materials have been studied in the field of biomedicine for more than forty years. The application principle of biodegradable materials in the medical field is to degrade macromolecular substances into small molecular substances that are not harmful to the body through hydrolysis and enzymolysis under the physiological conditions of the body, or small molecular substances degrade by themselves in the body, and finally It is completely absorbed and excreted through the metabolism of the body, without toxic and side effects on the body; biodegradable materials have been widely used in surgical sutures, artificial skin, bone fixation materials, and drug release agents in the body; the most common biomaterials are mainly Including polymer material...

Claims

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Application Information

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IPC IPC(8): C08G63/91A61L27/50A61L27/54A61L27/18
CPCA61L27/18A61L27/50A61L27/507A61L27/54A61L2300/406C08G63/912C08L67/04
Inventor 韩俊女赵英杰
Owner 荆门市诺维英新材料科技有限公司
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