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A microcapsule with pH response and intestinal targeting and preparation method thereof

A microcapsule, targeting technology, applied in microcapsules, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor targeted release effect, low embedding rate, poor stability, etc. , to achieve the effect of simple method, high solubility and high embedding rate

Active Publication Date: 2021-07-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the above-mentioned problems in the prior art, the present invention provides a microcapsule with pH response and intestinal targeting effect and its preparation method. The prepared microcapsules have good stability, which effectively solves the problems of low embedding rate, poor stability and poor targeted release effect in the prior art.

Method used

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  • A microcapsule with pH response and intestinal targeting and preparation method thereof
  • A microcapsule with pH response and intestinal targeting and preparation method thereof
  • A microcapsule with pH response and intestinal targeting and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] A preparation method for loading limonene microcapsules, comprising the following steps in turn:

[0031] (1) After the okra is cleaned and deseeded, the okra is sequentially freeze-dried and crushed to 60 meshes, and then the okra is ultrasonically extracted for 60 minutes at a temperature of 80° C., and then filtered, alcohol-precipitated and freeze-dried to obtain okra polysaccharides, and then Add pure water and filter through a filter membrane with a pore size of 0.2 μm to obtain a okra polysaccharide solution with a concentration of 2% by weight; wherein, the solid-liquid ratio in the ultrasonic extraction process is 20:1;

[0032] (2) Dissolving the gelatin with pure water, and then magnetically stirring to completely expand, the temperature during stirring is 50°C, the time is 80min, and the gelatin solution having a concentration of 2wt% is obtained by filtering through a filter membrane with a pore size of 0.2 μm;

[0033] (3) Stir and mix the okra polysacchar...

Embodiment 2

[0038] A preparation method for loading isoquercitrin microcapsules, comprising the following steps in turn:

[0039] (1) After the okra is cleaned and deseeded, the okra is sequentially freeze-dried and crushed to 60 meshes, and then the okra is ultrasonically extracted for 60 minutes at a temperature of 80° C., and then filtered, alcohol-precipitated and freeze-dried to obtain okra polysaccharides, and then Add pure water and filter through a filter membrane with a pore size of 0.2 μm to obtain a okra polysaccharide solution with a concentration of 3% by weight; wherein, the solid-liquid ratio in the ultrasonic extraction process is 20:1;

[0040] (2) Dissolving the gelatin with pure water, and then magnetically stirring to completely expand, the temperature during stirring is 50°C, the time is 100min, and the gelatin solution with a concentration of 3wt% is obtained by filtering through a filter membrane with a pore size of 0.2 μm;

[0041] (3) Stir and mix the okra polysac...

Embodiment 3

[0047] A preparation method for loading cinnamaldehyde microcapsules, comprising the following steps in turn:

[0048] (1) After the okra is cleaned and deseeded, it is freeze-dried and crushed to 60 meshes in turn, and then the okra is ultrasonically extracted for 80 minutes at a temperature of 60° C., and then filtered, alcohol-precipitated and freeze-dried to obtain okra polysaccharides, and then Add pure water and filter through a filter membrane with a pore size of 0.2 μm to obtain a okra polysaccharide solution with a concentration of 2% by weight; wherein, the solid-liquid ratio in the ultrasonic extraction process is 20:1;

[0049] (2) Dissolving the gelatin with pure water, and then magnetically stirring to completely expand, the temperature during stirring is 60°C, the time is 60min, and the gelatin solution with a concentration of 4wt% is obtained by filtering through a filter membrane with a pore size of 0.2 μm;

[0050] (3) Stir and mix the okra polysaccharide sol...

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Abstract

The invention provides a microcapsule with pH response and intestinal targeting and a preparation method thereof. The preparation method comprises the following steps: freeze-drying and pulverizing the okra, then ultrasonically extracting the okra, filtering, alcohol sinking and freeze-drying to obtain okra polysaccharide, adding pure water and filtering to obtain okra polysaccharide solution; adding pure water to dissolve gelatin, stirring to completely expand, and filtering through a filter membrane to obtain gelatin solution; stirring and mixing okra polysaccharide solution and gelatin solution, Then add the alcohol-soluble core material to the mixed solution, adjust the pH value, undergo ultrasonic treatment, stand still, centrifuge and freeze-dry to obtain the microcapsule with pH response and intestinal targeting effect. The present invention also includes the microcapsules with pH response and intestinal targeting effect obtained by the above method. The present invention can quickly prepare microcapsules with pH response and intestinal targeting effect, and has good stability, which effectively solves the problems of low embedding rate, poor stability and poor targeted release effect in the prior art .

Description

technical field [0001] The invention belongs to the technical field of microcapsules and preparation thereof, and in particular relates to a microcapsule with pH response and intestinal targeting function and a preparation method thereof. Background technique [0002] Microcapsules have become an important technology for stabilizing and delivering many unstable and lipophilic ingredients in food and pharmaceuticals. Proteins and polysaccharides are usually used as shell materials for microcapsules to create a physical barrier between the core material for protection and the external environment, thereby preventing Direct contact of the core material with moisture, oxygen, heat, light, acids or bases. The complex coacervation method is one of the most traditional and simplest methods for encapsulating and embedding drug delivery. The preparation conditions are simple, usually use non-toxic solvents, and the cost is low. It is based on the electrostatic attraction between the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/36A61K47/42A61K45/00A61K31/11A61K31/7048
CPCA61K9/5036A61K9/5057A61K31/11A61K31/7048A61K45/00
Inventor 段飞霞王星月田雪李晓李静雯
Owner SICHUAN UNIV
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