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Pharmaceutical composition for treating chronic atrophic gastritis and preparation method thereof

A technology of atrophic gastritis and composition, applied in the field of pharmaceutical preparations, can solve the problems of vicious circle, large side effects, strong dependence, etc., and achieve the effect of reversing gastric mucosal gland atrophy, safe medication and good curative effect

Inactive Publication Date: 2020-08-07
SHENZHEN HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine is generally used for palliative treatment, but the clinical curative effect on some patients is not good. Intestinal metaplasia and some dysplasia have no effective reversal effect

Method used

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  • Pharmaceutical composition for treating chronic atrophic gastritis and preparation method thereof
  • Pharmaceutical composition for treating chronic atrophic gastritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A pharmaceutical composition for the treatment of chronic atrophic gastritis, which is prepared from the following raw materials in parts by weight: Codonopsis 18g, Poria 12g, Atractylodes 12g, Fig 13g, Tangerine peel 10g, Vinegar xiangfu 9g, Curcuma vinegar 9g, Perilla 8g stems, 11g ginger magnolia roots, 12g salvia miltiorrhiza, 13g soil turtles, 13g fried chicken's inner gold, 9g fried hawthorn, 3g roasted licorice.

[0043] The above-mentioned pharmaceutical composition is granulated according to a conventional method, filled, and prepared into capsules to obtain a capsule preparation that meets the daily dosage of a normal adult.

[0044] The above-mentioned capsule preparation met the requirements through the animal toxicity test, and did not cause damage or death of mice.

[0045] The above-mentioned capsule preparation is used for the treatment of patients with clinical chronic atrophic gastritis, and the method is as follows:

[0046] (1) Case data

[0047] There are 10...

Embodiment 2

[0060] A pharmaceutical composition for the treatment of chronic atrophic gastritis, prepared from the following raw materials in parts by weight: Codonopsis 24g, Poria 16g, Atractylodes 16g, Fig 18g, Tangerine peel 16g, Vinegar odorata 13g, Curcuma vinegar 13g, Perilla 12g stems, 17g ginger magnolia roots, 16g salvia miltiorrhiza, 16g soil turtles, 17g fried chicken's inner gold, 12g fried hawthorn, 6g roasted licorice.

[0061] The above-mentioned pharmaceutical composition is made into tablets and carried out in accordance with conventional methods to obtain tablets that meet the daily dosage of normal adults for the treatment of patients with clinical chronic atrophic gastritis. The method is as follows:

[0062] (1) Case data

[0063] There are 100 cases of chronic atrophic gastritis, including 50 males and 50 females, aged between 25-75 years old.

[0064] (2) Treatment method

[0065] The capsule preparation prepared above is taken orally, divided into 2 times a day for 3 months...

Embodiment 3

[0072] A pharmaceutical composition for the treatment of chronic atrophic gastritis, which is prepared from the following raw materials in parts by weight: Codonopsis 20g, Poria 15g, Atractylodes 15g, Fig 15g, Tangerine peel 15g, Vinegar fragrant root 10g, Curcuma vinegar 10g, Perilla 10g stems, 15g ginger magnolia roots, 15g salvia miltiorrhiza, 15g soil turtles 15g, fried chicken's inner gold 15g, fried hawthorn 10g, roasted licorice 5g.

[0073] The above-mentioned pharmaceutical composition is made into tablets and prepared according to conventional methods to obtain tablets that meet the daily dosage of normal adults for the treatment of patients with clinical chronic atrophic gastritis. The method is as follows:

[0074] (1) Case data

[0075] There are 100 cases of chronic atrophic gastritis, including 50 males and 50 females, aged between 25-75 years old.

[0076] (2) Treatment method

[0077] The tablets prepared above were taken orally, divided into 2 times a day for 3 months...

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Abstract

The invention provides a pharmaceutical composition for treating chronic atrophic gastritis, and belongs to the technical field of Chinese herbal medicines. The pharmaceutical composition disclosed bythe invention is prepared from the following raw materials, by weight: 18-24 parts of root of hairy asiabell, 12-16 parts of poria cocos, 12-16 parts of bighead atractylodes rhizome, 13-18 parts of figs, 10-16 parts of dried tangerine or orange peel, 9-13 parts of vinegar-processed nutgrass galingale rhizome, 9-13 parts of vinegar-processed zedoray rhizome, 8-12 parts of perilla stems, 11-17 parts of officinal magnolia bark processed with ginger, 12-16 parts of salvia the root of red-rooted salvia, 13-16 parts of ground beeltle, 13-17 parts of fried inner membrane of chicken gizzard, 9-12 parts of fried hawthorn fruit and 3-6 parts of honey-fried licorice root. The pharmaceutical composition is safe to use, does not cause damage to gastrointestinal tract, liver and kidney functions of a patient, can reverse atrophy of gastric mucosa glands and metaplasia of intestinal epithelium, and has a good curative effect on treatment of chronic atrophic gastritis.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to a pharmaceutical composition for treating chronic atrophic gastritis and a preparation method thereof. Background technique [0002] Chronic atrophic gastritis (CAG) refers to chronic gastritis in which the gastric mucosa has undergone atrophic changes. The clinical manifestations are dyspeptic symptoms such as upper abdominal fullness, belching, and decreased appetite. After repeated damage to the surface of the gastric mucosa The resulting mucosal glands atrophy or even disappear, and the pathological changes of the mucous muscle layer are common thickening, which may be accompanied by intestinal metaplasia, inflammatory reaction and dysplasia. The disease is one of the common and frequently-occurring diseases of the digestive system. It accounts for about 10% to 30% of chronic gastritis. Its onset is slow, lingering, persistent and difficult to cure, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/04A61K35/64A61K35/57
CPCA61K35/57A61K35/64A61K36/076A61K36/284A61K36/344A61K36/484A61K36/535A61K36/537A61K36/575A61K36/60A61K36/734A61K36/752A61K36/8905A61K36/9066A61P1/04A61K2300/00
Inventor 羊燕群
Owner SHENZHEN HOSPITAL OF SOUTHERN MEDICAL UNIV
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