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c 3 no 4 Nanosphere-supported all-inorganic perovskite cspbbr 3 Preparation method and its electrochemiluminescent cell sensor

A C3N4, electrochemical technology, applied in the field of biological analysis, can solve the problems of the application of electrochemiluminescence of all-inorganic perovskite nanomaterials, poor electrochemiluminescence performance, hindering potential applications, etc. Chemiluminescent properties, increased sensitivity, improved instability

Active Publication Date: 2021-10-26
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to their intrinsic affinity with moisture, electrochemical hairs are poor and easily destroyed, hindering their potential application under normal conditions (W.Ke, M.G. Kanatzidis, Nat. Commun. 2019, 10, 965; A. Loiudice, S. Saris, E. Oveisi, D.T.L. Alexander, R. Buonsanti, Angew. Chem. Int. Ed. 2017, 56, 10696.)
Unfortunately, reliable electrochemiluminescent applications of all-inorganic perovskite nanomaterials have not been realized so far

Method used

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  • c <sub>3</sub> no <sub>4</sub> Nanosphere-supported all-inorganic perovskite cspbbr <sub>3</sub> Preparation method and its electrochemiluminescent cell sensor
  • c <sub>3</sub> no <sub>4</sub> Nanosphere-supported all-inorganic perovskite cspbbr <sub>3</sub> Preparation method and its electrochemiluminescent cell sensor
  • c <sub>3</sub> no <sub>4</sub> Nanosphere-supported all-inorganic perovskite cspbbr <sub>3</sub> Preparation method and its electrochemiluminescent cell sensor

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Embodiment 1

[0036] The present invention provides a C-based 3 N 4 Nanosphere-supported all-inorganic perovskite CsPbBr 3 Bioanalytical method for detecting the concentration of CD44-overexpressing MCF-7 cells of the composite.

[0037] C 3 N 4 Nanosphere-supported all-inorganic perovskite CsPbBr 3 The synthetic method of the composite material comprises the following steps: take 0.2035 g Cs 2 CO 3 , 10mL of octadecene, and 0.625mL of oleic acid were added to a three-necked flask, and placed in a vacuum oven at 100°C for 1h; 2 Heat to 150°C in the atmosphere until the solid is completely dissolved to form a precursor solution. Take 0.138gPbBr 2 , 1 mg hollow mesoporous C 3 N 4 Nanospheres ( figure 1 A), 10mL of octadecene was added to a three-necked flask respectively, and placed in a vacuum oven at 100°C for 1 hour; then 1.0mL of oleylamine and 1.0mL of oleic acid, which were previously dried in vacuum at 100°C, were added, and in N 2 Heat to 120°C in the atmosphere for 40 mi...

Embodiment 2

[0042] The invention provides a biological detection method for detecting the concentration of HeLa cells overexpressing the carcinoembryonic antigen.

[0043] C 3 N 4 Nanosphere-supported all-inorganic perovskite CsPbBr 3 The synthetic method of the composite material comprises the following steps: take 0.2035 g Cs 2 CO 3 , 5mL of octadecene, and 0.5mL of oleic acid were added to a three-necked flask, and placed in a vacuum oven at 100°C for 1h; then in N 2 Heat to 150°C in the atmosphere until the solid is completely dissolved to form a precursor solution. Take 0.138gPbBr 2 , 5 mg hollow mesoporous C 3 N 4 Nanospheres ( figure 1 A), 5 mL of octadecene were added to a three-necked flask, and placed in a vacuum oven at 100 °C for 1 h; then 1.0 mL of oleylamine and 1.0 mL of oleic acid that had been dried in vacuum at 100 °C were added, and in N 2 Heat to 120°C in the atmosphere for 40 minutes, and then continue to heat to 150°C to form a high-temperature reaction sol...

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Abstract

The invention belongs to the field of biological analysis and the field of electrochemiluminescence, and specifically relates to C 3 N 4 Nanosphere-supported all-inorganic perovskite CsPbBr 3 The preparation method and its electrochemiluminescent cell sensing, prepared C by in situ growth method 3 N 4 Nanosphere loaded CsPbBr 3 Composite material, and as the electrode luminescence substrate; then a probe is designed, which contains the targeting recognition part and the multifunctional DNA part, which in turn contains the enzyme cleavage site, the hybridization recognition fragment, and the initiation fragment of the hybridization chain reaction ; The probe first specifically targets the cell surface receptor, and then uses the restriction endonuclease Dra I to cut the multifunctional DNA part of the probe, and initiates a hybridization chain reaction in the solution to generate a large amount of long DNA chains used to intercalate rhodamine 6G; the product was then captured on the electrode surface through a hybridization reaction; due to the CsPbBr in the composite 3 It can undergo efficient resonance energy transfer with rhodamine 6G, causing the decrease of its electrochemiluminescence signal, thereby realizing the analysis of cell number.

Description

technical field [0001] The invention belongs to the field of biological analysis and the field of electrochemiluminescence, and specifically relates to C 3 N 4 Nanosphere-supported all-inorganic perovskite CsPbBr 3 Preparation method and its electrochemiluminescent cell sensing. Background technique [0002] The research on semiconductor nanomaterials is one of the current research hotspots in material science, and its unique optical and electrical properties make it widely used in many fields. Further improving the performance of nanomaterials and developing unique photoelectric properties of new nanomaterials, so that they can be better applied in practical problems, has always been one of the concerns of scientific researchers. In recent years, as a new semiconductor material, lead halide perovskite has been widely used in solar cells, light-emitting diodes, lasers, photodetectors, capacitors, photocatalysis, and other fields (Y.Cao, Z.Zhang , L. Li, J.R. Zhang, J.J. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/66G01N21/76
CPCC09K11/665G01N21/76
Inventor 朱俊杰曹越马诚
Owner NANJING UNIV
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