Hydrogel-patch-type pharmaceutical composition for transdermal administration
A hydrogel patch and composition technology, applied in medical preparations containing active ingredients, medical science, pharmaceutical formulations, etc., can solve the problem of long cross-linking time, difficulty in adjusting adhesion and gel strength, and difficulty in application Problems such as the preparation process, to achieve the effects of low viscosity, excellent formulation and operability, and excellent transdermal permeability
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[0038] The invention also provides a preparation method of the pharmaceutical composition in the form of hydrogel patch. For example, the present invention provides a method for preparing a pharmaceutical composition in the form of a hydrogel patch comprising the steps of: (a) dissolving an active pharmaceutical ingredient or an active pharmaceutical ingredient and a penetration enhancer, optionally together with a fragrance, in co-solvent, thereby preparing the first solution; (b) acid, chelating agent and viscosity modifier dissolved in water, thereby preparing the second solution; (c) partially neutralized polyacrylic acid, cross-linking agent and anti-leakage agent dispersing in a dispersant to prepare a dispersion; and (d) mixing the first solution, the second solution and the dispersion to form a hydrogel.
[0039] In the preparation method of the present invention, the step (a), step (b) and step (c) do not have to be performed sequentially, which is obvious to those sk...
Embodiment 1 to Embodiment 6
[0042] Example 1 to Example 6: Preparation of hydrogel and patch containing the hydrogel
[0043] Hydrogels were prepared according to the ingredients and contents in Table 1 below. The content in Table 1 represents the weight % of each component in the hydrogel. Add flurbiprofen and L-menthol to co-solvents [propylene glycol, polysorbate 80 and / or sorbitan monooleate (Span 80 TM (Span80 TM))] and stirred at 50-55°C to dissolve (Solution A). Tartaric acid, sodium edetate and a viscosity modifier [sodium carboxymethylcellulose and / or hydroxypropylcellulose] were added to purified water and stirred at about 40°C to dissolve (solution B). Partially neutralized polyacrylic acid (Viscomate NP-800 TM , Showa Denko Co., Ltd.), cross-linking agent [aluminum hydroxide and / or aluminum dihydroxyglycinate] and anti-leakage agent [polyacrylic acid and / or kaolin] dispersed in dispersant [glycerin and / or polyethylene glycol] (Dispersion C). The solution A and solution B were mixed, and...
Embodiment 7 to Embodiment 11
[0047] Example 7 to Example 11: Preparation of hydrogel and patch containing the hydrogel
[0048] Hydrogels were prepared according to the ingredients and contents in Table 2 below. The contents in Table 2 represent the weight % of each component in the hydrogel. Add loxoprofen sodium hydrate, isostearyl glyceryl ether and L-menthol to co-solvent [propylene glycol, polysorbate 80 and / or sorbitan monooleate (Span 80 TM (Span80 TM ))] and stirred at 50-55°C to dissolve (Solution A). Acid [tartaric acid or acetic acid], sodium edetate and viscosity modifier [sodium carboxymethylcellulose and / or gelatin] were added to purified water and stirred at about 40°C to dissolve (solution B). Partially neutralized polyacrylic acid (Viscomate NP-800 TM , Showa Denko Co., Ltd.), cross-linking agent [aluminum hydroxide and / or aluminum dihydroxyglycinate] and anti-leakage agent [polyacrylic acid and / or kaolin] dispersed in dispersant [glycerin and / or polyethylene glycol] (Dispersion C). ...
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Abstract
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