Normalization and baseline shift removal for NANO pore-sbs signals
A nanopore, signal value technology, applied in biochemical equipment and methods, informatics, bioinformatics, etc., can solve problems such as inaccuracy and difficulty in determining molecules
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[0046] According to certain embodiments, the methods and systems disclosed herein relate to improvements in the processing of nanopore sequencing signals, such as voltage signals as measured by ADCs connected to nanopore cells. More specifically, the methods and systems disclosed herein correct for both gain drift and baseline shift in nanopore sequencing signals.
[0047] The baseline shift phenomenon in the nanopore sequencing signal can be related to the charge imbalance that occurs during the measurement process and builds up on certain inherently capacitive elements in the system (e.g., the working electrode of the cell) during charge and discharge cycles related. Gain shifts in the signal can be caused by relatively slow (hundreds or thousands of seconds) changes in membrane capacitance where the membrane (eg, bilayer) covers the pores. Such membrane capacitance may change in a deterministic manner, for example in response to physical changes in the bilayer.
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