Lactobacillus plantarum SD-H9, probiotic microbial agent of Lactobacillus plantarum SD-H9, and application of Lactobacillus plantarum SD-H9

A technology of Lactobacillus plantarum and probiotics, applied in the field of microorganisms, can solve the problems of prone to lesions of the nasal mucosa and the harm of human side effects and medication, and achieve the effects of improving nasal allergic symptoms, changing cell bias, and alleviating allergic reactions.

Active Publication Date: 2020-09-11
深圳华大基因农业控股有限公司
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Problems solved by technology

[0003] At present, rhinitis is mainly treated by nasal cleaning drugs prepared from bactericidal drugs or aspirin, ibuprofen, chlorpheniramine and other antibiotic drugs. Neglecting the use of antibiotics to clean or ster

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  • Lactobacillus plantarum SD-H9, probiotic microbial agent of Lactobacillus plantarum SD-H9, and application of Lactobacillus plantarum SD-H9
  • Lactobacillus plantarum SD-H9, probiotic microbial agent of Lactobacillus plantarum SD-H9, and application of Lactobacillus plantarum SD-H9
  • Lactobacillus plantarum SD-H9, probiotic microbial agent of Lactobacillus plantarum SD-H9, and application of Lactobacillus plantarum SD-H9

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[0017] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the embodiments and accompanying drawings. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0018] Isolation and identification of Lactobacillus plantarum SD-H9

[0019] Take 10g of healthy human intestinal excreta and carry out 10-fold gradient dilution with sterile physiological saline, and dilute the sample by 10 6 Spread on the MRS agar medium after doubling, cultivate for 24 hours, observe the colony morphology, pick out a single colony suspected of lactic acid bacteria, streak and isolate it on a new MRS agar medium, culture for 24 hours, and perform streak separation and purification again. A sterile toothpick was used to pick several single colonies from the medium separated...

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Abstract

The invention proposes Lactobacillus plantarum SD-H9, and a probiotic microbial agent of the Lactobacillus plantarum SD-H9, and an application of the Lactobacillus plantarum SD-H9. The Lactobacillus plantarum SD-H9 of the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC), and a preservation number is CGMCC NO.16649. The probiotic microbial agent providedby the invention can effectively alleviate nasal symptoms of rats with allergic rhinitis, reduces the content of histamine, OVA-specific IgE and IL-4 in the serum of the rhinitis rats, improves the content of IFN-gamma in the serum of the rats, helps to alleviate allergic reactions, induces correct immune responses, thereby changes the bias of Th2 cells that promote allergic reactions, plays a role in the treatment of allergic rhinitis by regulating the immune function of a host, and can effectively improve the symptoms of rhinitis.

Description

technical field [0001] The invention belongs to the technical field of microbes, and in particular relates to a plantarum lactobacillus SD-H9, its probiotic agent and its application. Background technique [0002] Allergic rhinitis is a common and frequently occurring disease of the respiratory system. Its main clinical manifestations are nasal congestion, nasal itching, paroxysmal sneezing, a large amount of watery nasal discharge, and olfactory dysfunction. In addition, it may also cause or be complicated by sinusitis , nasal polyps, pharyngitis, otitis media, trachea and bronchitis, chest pain, chest tightness, asthma and allergic conjunctivitis and other diseases seriously affect the quality of life of patients, endanger people's health and easily induce various diseases. Allergic rhinitis is mainly caused by the inhalation of allergens by patients and the release of inflammatory mediators, leading to inflammation of the nasal mucosa. The number of people suffering from...

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Application Information

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IPC IPC(8): C12N1/20A61K35/747A61P11/02A61P37/08C12R1/25
CPCC12N1/20A61K35/747A61P11/02A61P37/08C12R2001/25C12N1/205
Inventor 王明明蒋蕊赵山岑刘松玲代晓霜宋颀任军丽
Owner 深圳华大基因农业控股有限公司
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