Application of microbial flora in acute pancreatitis

A technology for acute pancreatitis and microorganisms, applied in the field of application of microbiota in acute pancreatitis, can solve the problems of complex scoring system, not often used by clinicians, cumbersome and other problems, and achieve the effect of improving the quality of life

Inactive Publication Date: 2020-09-11
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Claims
  • Application Information

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Problems solved by technology

However, these scoring systems are complex, cumbersome, and have

Method used

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  • Application of microbial flora in acute pancreatitis
  • Application of microbial flora in acute pancreatitis
  • Application of microbial flora in acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Detection of Microflora Associated with Acute Pancreatitis

[0037] 1. Collection of samples

[0038] Rectal cotton swab samples were collected from 20 healthy individuals and 60 patients with acute pancreatitis. The patient statistics are shown in Table 1.

[0039] Inclusion criteria of patients: in line with the 2012 new Atlanta acute pancreatitis classification criteria.

[0040] Exclusion criteria for patients without immunodeficiency, allergies, asthma, colon cancer, diabetes mellitus, HIV, inflammatory bowel disease, irritable bowel syndrome, gastroenteritis, anesthesia enterocolitis, and arthritis.

[0041] Inclusion criteria for healthy controls: no metabolic, cardiovascular and cerebrovascular diseases, and intestinal diseases; no pregnancy, no known allergens; no drug treatment affecting intestinal function; no diet for weight loss or other specific purposes.

[0042] Exclusion criteria for patients and healthy controls: taking antibiotics, probio...

Embodiment 2

[0102] Example 2 The diagnostic efficiency of Ruminococcus_gauvreuii_group

[0103] According to the relative content of Ruminococcus_gauvreuii_group, the receiver operating characteristic curve (ROC) was drawn using SPSS, and the binomial exact confidence space was calculated to analyze the sensitivity and specificity of Ruminococcus_gauvreuii_group for the diagnosis of acute pancreatitis.

[0104] The ROC curve and characteristic parameters are as follows figure 2 As shown in Tables 2-3, the area under the curve is 0.904, the threshold of the optimal critical point is 109.5, the sensitivity of this point is 0.833, and the specificity is 0.85, which has high sensitivity and specificity, indicating that the application of Ruminococcus_gauvreuii_group It has high sensitivity, specificity and accuracy in the diagnosis of acute pancreatitis. Based on the findings of this study, acute pancreatitis can be prevented or treated by adjusting the abundance of Ruminococcus_gauvreuii_g...

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Abstract

The invention discloses application of microbial flora in acute pancreatitis. The microbial flora is Ruminococcus_gauvreauii_group. The microbial marker has high sensitivity and high specificity during prediction of acute pancreatitis. Through detection of the abundance of the microbial marker, subjects can be warned, and risks can be reduced further through dietary adjustment or medical intervention.

Description

technical field [0001] The invention belongs to the field of biotechnology and relates to the application of microbial flora in acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is an inflammatory disease that can lead to local injury, systemic inflammatory response syndrome (SIRS) and organ failure. With the continuous development and progress of society, the improvement of people's living standards, high-fat diet, low exercise, excessive work pressure, alcohol abuse and other reasons, the incidence of pancreatitis increases, leading to an increase in the incidence of acute pancreatitis. Acute pancreatitis accounts for 3%-10% of acute abdomen, which is a common clinical acute abdomen. The disease is very disruptive to physiology. It has the characteristics of quick onset, rapid development, high risk and high mortality. It is relatively difficult to distinguish acute pancreatitis from other non-acute pancreatitis-type acute abdomen in the acute ph...

Claims

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Application Information

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IPC IPC(8): C12Q1/689C12Q1/06G01N33/569A23L33/135A61K45/00A61P1/18C12R1/01
CPCA61K45/00A23L33/135A61P1/18C12Q1/689G01N33/56911G01N2333/195G01N2800/067
Inventor 吴东李佳宁施文陈国榕宋锴龚亮吉利李景南钱家鸣
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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