Methods, apparatuses, and systems for the treatment of disease states and disorders

An algorithmic, energy-delivery technique with application in the field of treatments, devices and systems for disease states and disorders

Pending Publication Date: 2020-09-22
GALVANIZE THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0040] Thus, there is an unmet need for more controlled interventions targeting specific structures and/or pathogens matched to pathophysiological abnor

Method used

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  • Methods, apparatuses, and systems for the treatment of disease states and disorders
  • Methods, apparatuses, and systems for the treatment of disease states and disorders
  • Methods, apparatuses, and systems for the treatment of disease states and disorders

Examples

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example 1

[0609] Example 1: Circumferential Therapy and Tissue Effects Using a Bipolar System

[0610] A non-thermal energy delivery device with a bipolar expandable energy delivery body was developed. The device consists of two energy delivery bodies, each consisting of nitinol, braided, expanding electrodes mounted concentrically on a catheter shaft, with a mechanism to expand and contract both energy delivery bodies ( For example, see Figure 27 ). The expanded energy delivery body diameter ranges from about 5mm to about 20mm. The energy delivery bodies were substantially equal in length, each about 3 cm, and spaced about 2.5 cm apart from edge to edge along the longitudinal axis of the catheter shaft. To assess the effect of pulsed high-voltage energy on the epithelial and submucosal layers within the airways, the device was introduced into the left and / or right bronchi of live, anesthetized pigs and administered as bipolar, square-wave pulses at approximately Energy was deliver...

example 2

[0613] Example 2: Circumferential Therapy and Tissue Effects Using a Monopolar System

[0614] A non-thermal energy delivery device with a unipolar expandable energy delivery body was developed. The device consists of a single energy delivery body consisting of nitinol, braided, expanding electrodes mounted concentrically on a catheter shaft with a mechanism for expanding and contracting the energy delivery body (see e.g. Figure 26 ). The extended energy delivery diameter ranges from about 5mm to about 20mm. To assess the effects of pulsed high-voltage energy on the epithelial and submucosal layers within the airways, the device was introduced into the left and / or right bronchi of live, anesthetized pigs and delivered as bipolar, square-wave pulses at 300 kHz The pulse frequency, the pulse amplitude of 4000V and the total energy delivery duration of 415 microseconds (83 microseconds per packet, 5 packets) deliver energy.

[0615]Following this procedure, animals were allow...

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Abstract

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, andbasal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis,bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No.: 62 / 610,430, filed December 26, 2017, entitled "Methods, Apparatuses, and Systems for the Treatment of Pulmonary Disorders," the entire contents of which are incorporated herein by reference for all purposes. Background technique [0003] I. Anatomy [0004] Figure 1 provides an illustration of the anatomy of the lung. Air travels down the trachea T ​​and into the lungs L, where the trachea T ​​branches into multiple airways extending throughout the lungs L. The trachea T ​​first bifurcates into the right and left mainstem bronchi MB at the carina CA. These main bronchi MBs are further divided into lobar bronchi LB, segmental bronchi SB, subsegmental bronchi SSB, and terminate in alveolar A. The diameter of the airway decreases as the airway bifurcates. The trachea T ​​may have a lumen diameter of about 15 mm to 22 mm, the main bronchi MB ma...

Claims

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Application Information

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IPC IPC(8): A61B18/12A61B18/14A61B18/00
CPCA61B18/1206A61B18/1492A61B2018/0022A61B2018/00267A61B2018/00351A61B2018/00541A61B2018/00577A61B2018/00839A61B2018/124A61B2018/1253A61B2018/1467A61B2018/1475A61B1/2676A61N1/06A61N1/326A61N1/362
Inventor J·R·沃尔德斯特雷切尔W·S·克里姆斯基D·M·泽伦斯R·J·贝泰尔三世P·B·弗雷德里克斯K·J·泰勒R·图尔罗弗斯基G·L·龙R·E·尼尔二世
Owner GALVANIZE THERAPEUTICS INC
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