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Natural immunity activator, application thereof, natural TIL cell accelerant and application of natural TIL cell accelerant

A technology of natural immunity and immune cells, applied in the field of medicine, can solve the problem of little research on the application of icariin I, and achieve the effects of enhancing or T cell anti-tumor function, improving curative effect, and enhancing infiltration.

Pending Publication Date: 2020-09-25
FOSHAN GOLDEN HEALTH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, epimedium extract has been reported to have the function of regulating the body's immune system and has anti-tumor activity, but there are still not many studies on the application of icariside I

Method used

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  • Natural immunity activator, application thereof, natural TIL cell accelerant and application of natural TIL cell accelerant
  • Natural immunity activator, application thereof, natural TIL cell accelerant and application of natural TIL cell accelerant
  • Natural immunity activator, application thereof, natural TIL cell accelerant and application of natural TIL cell accelerant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Toxicity Evaluation Test of Icariside I

[0047] Select 21 SPF-grade C57 female mice and randomly divide them into 7 groups including groups A, B, C, D, E, F and G, with three mice in each group. Administration was carried out by intragastric administration, wherein, group A was the control group (control), and 0.2ml / kg bw corn oil was used for intragastric administration, and groups B to G were given 5mg / kg bw, 20mg / kg bw, 80mg / kg·bw, 160mg / kg·bw, 320mg / kg·bw, 640mg / kg·bw of icariside I, after 7 days of continuous administration, kill the mice, observe the conditions of the various organs of the mice, And collect the organs and plasma of the mice for analysis, the results are as follows: figure 1 shown.

[0048] In this example, icariside I is extracted from Epimedium Herba, with a purity greater than 90%.

[0049] from figure 1 It can be seen that, compared with the mice without intragastric administration of icariside I, the weight of liver, spleen, kidney and th...

Embodiment 2

[0051] Effects of icariside I on immune activation and TIL promotion in mice with liver cancer

[0052] (1) Modeling: A mouse model of liver cancer was constructed with mouse liver cancer HepG2 cells.

[0053] (2) Grouping: taking the unmodeled normal mice as the normal group of group A, the liver cancer mouse models made in step (1) were randomly divided into groups B, C, D, and E, a total of 5 groups, each with three mice.

[0054] (3) Administration: administration by intragastric administration, wherein, group A and group B were given 0.2ml / kg bw corn oil; ; Group D is a middle-dose group, given 20 mg / kg bw of icariside I; group E is a high-dose group, given 80 mg / kg bw of icariside I for 7 consecutive days.

[0055] (4) Observation and detection: During the administration period, observe the mice's appetite, defecation, urine, activity, etc. every day; after 7 days of administration, use the technology of flow cytometry to detect the peripheral blood immune subpopulatio...

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Abstract

The invention discloses a natural immunity activator and a natural TIL cell accelerant which comprise icariside I. The natural immunity activator can increase the proportion of varied immunity cell subsets in peripheral blood, besides, can increase the CD8+ / CD4+ ratio in the peripheral blood, and can activate an immune system; and the natural TIL cell accelerant can promote immunocyte in the peripheral blood to perform infiltration on tumor tissue, the proportion of the TIL cells in tumors can be increased, particularly infiltration of CD8+ cells in the tumor tissue is increased, the CD8+ / CD4+ratio is increased, and T cells are increased to restrain growth of the tumors. The invention further discloses an application of the natural immunity activator and the natural TIL cell accelerant totumor immunotherapy, the content of the immunocyte in patients suffering from tumors can be increased, the difficult problem that during present tumor immunotherapy, infiltration and / or accumulationof the CD8+ cells in tumor microenvironment is deficient can be solved, and the curative effect of the tumor immunotherapy can be increased.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an innate immune activator, a TIL promoter and applications thereof. Background technique [0002] Malignant tumors are one of the leading causes of death for humans. The Global Cancer Report 2014 released by the World Health Organization (WHO) predicts that global cancer cases will show rapid growth, from 14 million in 2012 to 19 million in 2025. people, will reach 24 million by 2035; 8.8 million people died of cancer worldwide in 2015, accounting for one-sixth of global deaths. The current cancer treatment methods largely rely on cytotoxic chemotherapy and radiotherapy, which have toxic side effects on normal cells, and are prone to drug resistance of tumor cells, increasing the difficulty of tumor treatment, which severely limits Application of Chemotherapy and Radiation Therapy. [0003] At present, tumor immunotherapy has opened up a new field for the treatment of tumors....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P37/02A61P35/00
CPCA61K31/7048A61P37/02A61P35/00
Inventor 李慧灵陈桂周金林张利民卢宇靖林丽薇林育成叶德晓
Owner FOSHAN GOLDEN HEALTH TECH CO LTD
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