A microfluidic chip for monitoring nematode motility behavior and physiological characteristics

A microfluidic chip, a technology of physiological characteristics, applied in laboratory containers, chemical instruments and methods, material resistance, etc., can solve the problems of low work efficiency, few parameters that can be measured simultaneously, difficult to control the culture environment, etc. The effect of high-efficiency cultivation

Active Publication Date: 2022-03-29
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Nematode research in the prior art uses platinum probes on the surface of the agarose gel, which has low work efficiency, difficult control of the culture environment, and few parameters that can be measured simultaneously

Method used

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  • A microfluidic chip for monitoring nematode motility behavior and physiological characteristics
  • A microfluidic chip for monitoring nematode motility behavior and physiological characteristics
  • A microfluidic chip for monitoring nematode motility behavior and physiological characteristics

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Embodiment Construction

[0026] The technical solution of the present invention will be further described below in conjunction with the accompanying drawings.

[0027] refer to figure 1 , figure 2 , which is a schematic structural view of a microfluidic chip and a schematic plan view of a fluid channel provided in an embodiment of the present invention.

[0028] An embodiment of the present invention provides a microfluidic chip for nematode detection, including: a substrate, a fluid inlet 1, a culture chamber array 2, a sampling channel 3, a sampling control valve 4, an electrical impedance tomography detection chamber 5, an electrical impedance Tomographic imaging electrode array 6, electrical impedance spectroscopy detection chamber 9, electrical impedance spectroscopy detection electrode array 10, detection control valve 8, fluid outlet 11, wherein:

[0029] The substrate is used to carry microfluidic chip components;

[0030] The fluid inlet 1, the culture chamber array 2, the sampling channe...

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Abstract

The invention discloses a microfluidic chip for monitoring nematode movement behavior and physiological characteristics, wherein: a fluid inlet, a culture chamber array, a sampling channel, an electrical impedance tomography detection chamber, an electrical impedance spectrum detection chamber and a fluid outlet are sequentially connected The sampling control valve is set on the sampling channel for controlling the conduction or closing of the channel; the detection control valve is set between the electrical impedance tomography detection chamber and the electrical impedance spectroscopy detection chamber for controlling the conduction or closure of the channel Closed; the electrical impedance tomography electrode array is connected to the electrical impedance tomography detection cavity; the electrical impedance spectrum detection electrode array is connected to the electrical impedance spectrum detection cavity. Using the above technical scheme, the integration of the culture chamber, electrical impedance tomography detection chamber and electrical impedance spectroscopy detection chamber can be realized, and the functions of nematode cultivation, movement behavior and physiological structure detection can be realized. Combined with the control valve, high automation, Efficient cultivation and detection.

Description

technical field [0001] The invention relates to the field of microfluidic chips, in particular to a microfluidic chip used for monitoring the movement behavior and physiological characteristics of nematodes. Background technique [0002] Microfluidics Chip (Microfluidics Chip) is a cutting-edge technology for fluid manipulation by manufacturing submicron-scale microchannels and chamber networks through micromachining technology, and integrates operations in traditional biochemical analysis laboratories on tiny chips. The intersection of microfluidic chip technology and fluid mechanics, electromagnetics, acoustics, optics and other disciplines has been widely used in the research of biology and chemistry. Nematodes are commonly used model organisms in biological research. [0003] The microfluidic chip used for nematode biology research in the prior art lacks the ability to detect the movement behavior and physiological structure of nematodes. Nematode research in the prior...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/07B01L3/00
CPCG01N27/07B01L3/5027B01L2300/0819
Inventor 朱真徐星宇王昊曦杨剑坤
Owner SOUTHEAST UNIV
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