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Application of p-hydroxyphenylacetic acid in prevention and/or treatment of cardiovascular diseases

A p-hydroxyphenylacetic acid and angiogenesis technology, applied in the medical field, can solve the urgent needs of safe and effective cardiovascular drug research and development, and achieve the effect of reducing venous congestion, reducing heart dilation, and increasing the length of blood vessels

Active Publication Date: 2022-03-15
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are safety problems such as liver toxicity and muscle damage in the treatment of cardiovascular drugs, which makes the research and development of cardiovascular drugs a severe situation, and there is an urgent demand for the research and development of safe and effective cardiovascular drugs

Method used

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  • Application of p-hydroxyphenylacetic acid in prevention and/or treatment of cardiovascular diseases
  • Application of p-hydroxyphenylacetic acid in prevention and/or treatment of cardiovascular diseases
  • Application of p-hydroxyphenylacetic acid in prevention and/or treatment of cardiovascular diseases

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Embodiment Construction

[0013] In order to facilitate a further understanding of the present invention, the examples provided below illustrate it in more detail. However, these examples are only for a better understanding of the invention and are not used to limit the scope or implementation principle of the invention, and the embodiments of the invention are not limited to the following content.

[0014] Effects of HPA on interbody vascular injury, inferior intestinal vein growth, heart failure and arrhythmia in zebrafish.

[0015] 1. Experimental animals

[0016] Animals used in blood vessel injury and inferior intestinal vein growth experiments of the present invention are vascular fluorescence transgenic Tg (fli-1:EGFP) zebrafish, animals used in heart failure experiments are AB wild-type zebrafish, and animals used in heart failure experiments are heart fluorescent transgenic Tg (cmlc2:GFP) line zebrafish. Breed under the conditions of 28°C, dark / light (10:14) photoperiod, and feed brine shrim...

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Abstract

The invention relates to the application of p-hydroxyphenylacetic acid in the prevention and / or treatment of cardiovascular diseases. The invention firstly finds that p-hydroxyphenylacetic acid has a better therapeutic effect on blood vessel and heart damage. For zebrafish interbody vessel (ISV) injury and inferior intestinal vein (SIV) growth induced by vascular endothelial cell growth factor receptor inhibitor (PTK787), p-hydroxyphenylacetic acid can significantly promote angiogenesis. increase in the number and length of blood vessels. For verapamil-induced zebrafish heart failure and terfenadine-induced arrhythmia, p-hydroxyphenylacetic acid has a significant protective effect on the heart, can significantly reduce cardiac dilation, relieve venous congestion and promote heart rate to normalize.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an application of p-hydroxyphenylacetic acid in preventing and / or treating cardiovascular diseases. Background technique [0002] Cardiovascular disease is a common disease with the characteristics of "high morbidity, high disability rate, high mortality rate, high recurrence rate, and many complications", which seriously threatens human health. Cardiovascular and cerebrovascular diseases cause 15 million deaths worldwide every year, ranking first among various causes of death. At present, there are safety problems such as liver toxicity and muscle damage in the treatment of cardiovascular drugs, which makes the research and development of cardiovascular drugs severe, and there is an urgent need for the research and development of safe and effective cardiovascular drugs. [0003] Zebrafish is an important model organism for early rapid screening and target localization of car...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P9/00A61P9/14A61P9/04A61P9/06
CPCA61K31/192A61P9/00A61P9/14A61P9/04A61P9/06
Inventor 张梦启刘可春李晓彬李培海孔浩天李昊楠张云夏青王荣春
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
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