Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Purification method of cannabidiol

A purification method and technology of cannabidiol, applied in the field of biochemical industry, can solve the problems of high production cost and large investment of cannabidiol

Active Publication Date: 2020-10-20
深圳市云麻生物科技有限公司
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of high production cost and large investment of cannabidiol, the present invention provides a purification method of cannabidiol, which can greatly reduce production cost, and can reduce equipment investment and plant area

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Purification method of cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 100g of ethanol crude extract of industrial hemp with 16.2% cannabidiol content, heat and reflux with 300ml of ethanol at 80°C for 20 minutes, after dissolving, add 3200ml of sulfuric acid aqueous solution with pH=4, stir at 120r / min for 10 minutes, let stand After 8 hours, divide the dehydration solution to obtain 510ml of precipitation solution; add 3200ml of sodium hydroxide aqueous solution with pH=10 to the above precipitation solution, stir at 120r / min for 10 minutes, let stand for 12 hours, and divide the dehydration solution to obtain 480ml of precipitation solution ; Add 3800ml of purified water to the above precipitation solution, stir at 120r / min for 10 minutes, let it stand for 12 hours, filter the dehydrated solution, and obtain 134g of aqueous precipitation; add 550ml of absolute ethanol to the above precipitation, heat at 70°C and 120r / min Stir for 15 minutes, after dissolving, let stand at 5°C for 6 hours, remove the insoluble matter by filtration, s...

Embodiment 2

[0025] Take 100g of methanol crude extract of industrial hemp with 16.5% cannabidiol content, heat and reflux with 400ml of methanol at 70°C for 30 minutes, after dissolving, add 5000ml of nitric acid aqueous solution with pH=4.5, stir at 120r / min for 10 minutes, let stand After 10 hours, divide the dehydration solution to obtain 490ml of precipitation solution; add 3000ml of potassium hydroxide aqueous solution with pH=11 to the above precipitation solution, stir at 120r / min for 15 minutes, let stand for 12 hours, and divide the dehydration solution to obtain 450ml of precipitation solution ; Add 3500ml of purified water to the above precipitate, stir at 120r / min for 10 minutes, let it stand for 12 hours, filter or centrifuge to separate the dehydrated liquid, and get 105g of aqueous precipitate; add 400ml of methanol to the above precipitate, heat at 70°C and 120r / min Stir for 10 minutes, after dissolving, let it stand at 0°C for 4 hours, filter or centrifuge to remove insolu...

Embodiment 3

[0027] Take 100g of 6# solvent oil crude extract of industrial hemp with a cannabidiol content of 15.8%, heat and reflux with 500ml acetone at 60°C for 30 minutes, after dissolving, add 5500ml of nitric acid aqueous solution with pH=3.5, and stir at 120r / min for 10 minutes , stand still for 12 hours, divide the dehydration liquid to obtain 485ml of precipitation solution; add 3500ml of lithium hydroxide aqueous solution with pH=10 to the above precipitation solution, stir at 120r / min for 15 minutes, let stand for 12 hours, and divide the dehydration liquid to obtain 430ml of precipitation solution; add 4500ml of purified water to the above precipitation solution, stir at 120r / min for 10 minutes, let it stand for 12 hours, filter the dehydrated solution, and obtain 103g of aqueous precipitation; add 500ml of acetone to the above precipitation, heat at 60°C and 120r / min Min and stirred for 10 minutes, after dissolving, stand at 10°C for 10 hours, filter to remove insoluble matter...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a purification method of cannabidiol. The purification method comprises the following steps: removing a large amount of impurities from an extract of an industrial cannabidiol crude extract by a solvent method, and directly crystallizing and re-crystallizing to prepare high-purity cannabidiol. The purification method does not need expensive chromatography equipment, large heat supply equipment or concentration equipment, and the problem that the cannabidiol production investment is large is solved. Because a large amount of solvent and heat energy is not consumed in theproduction process, compared with a chromatography process, the production cost is greatly reduced.

Description

technical field [0001] The invention relates to a method for purifying cannabidiol, in particular to a method for purifying cannabidiol with industrial hemp extract, and belongs to the field of biochemical industry. Background technique [0002] Cannabidiol is a non-psychoactive ingredient extracted from industrial hemp, which does not cause physiological dependence, has good tolerance and high safety, and is effective for neurological diseases, epilepsy, tumors, depression, Parkinson's, and Alzheimer's It has shown good therapeutic properties in many diseases, such as inflammation, pain and so on. The application of cannabidiol in the field of medicine will have broad market prospects. [0003] At present, there are many methods for extracting cannabidiol concentrates, but the separation and purification of cannabidiol from crude extracts basically adopts column chromatography. This method mainly has the following disadvantages: column chromatography equipment is expensive...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C39/23C07C37/68C07C37/84C07C37/86
CPCC07C37/685C07C37/84C07C37/86C07C2601/16C07C39/23Y02P20/54
Inventor 王金华彭宇兵丁燕龙
Owner 深圳市云麻生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com