A biological nondestructive blood glucose detection device and its preparation method

A technology for blood sugar detection and living organisms, which is applied in the direction of carbon-silicon compound conductors, sensors, diagnostic recording/measurement, etc., can solve the problems of unsatisfactory device sensitivity and reduced electrode conductivity, and achieve good sensitivity, good stability, and high sensitivity Effect

Active Publication Date: 2021-11-09
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to keep the glucose oxidase from falling off, a perfluorosulfonic acid polymer (Nafion) solution is usually applied, resulting in a decrease in the conductivity of the electrode, and the sensitivity of the device is very unsatisfactory

Method used

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  • A biological nondestructive blood glucose detection device and its preparation method
  • A biological nondestructive blood glucose detection device and its preparation method
  • A biological nondestructive blood glucose detection device and its preparation method

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Experimental program
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Effect test

Embodiment 1

[0061] Such as Figure 11 As shown, a biological nondestructive blood glucose detection device, the detection device includes a working electrode 1 and a counter electrode 2 arranged side by side, the working electrode 1 includes a working electrode flexible substrate 102, a working electrode conductive substrate arranged on the working electrode flexible substrate 102, and The glucose oxidase loaded on the conductive substrate of the working electrode, the conductive substrate of the working electrode and the glucose oxidase form a graphene / carbon nanotube / glucose oxidase composite fiber fabric 101, and the opposite electrode 2 includes a flexible substrate 202 of the opposite electrode, which is located on the opposite electrode The opposite electrode conductive substrate on the flexible substrate 202 and the silver / silver chloride film plated on the opposite electrode conductive substrate, the opposite electrode conductive substrate and the silver / silver chloride film form g...

Embodiment 2

[0086] Such as Figure 11 As shown, a biological nondestructive blood glucose detection device, the detection device includes a working electrode 1 and a counter electrode 2 arranged side by side, the working electrode 1 includes a working electrode flexible substrate 102, a working electrode conductive substrate arranged on the working electrode flexible substrate 102, and The glucose oxidase loaded on the conductive substrate of the working electrode, the conductive substrate of the working electrode and the glucose oxidase form a graphene / carbon nanotube / glucose oxidase composite fiber fabric 101, and the opposite electrode 2 includes a flexible substrate 202 of the opposite electrode, which is located on the opposite electrode The opposite electrode conductive substrate on the flexible substrate 202 and the silver / silver chloride film plated on the opposite electrode conductive substrate, the opposite electrode conductive substrate and the silver / silver chloride film form g...

Embodiment 3

[0096] Such as Figure 11 As shown, a biological nondestructive blood glucose detection device, the detection device includes a working electrode 1 and a counter electrode 2 arranged side by side, the working electrode 1 includes a working electrode flexible substrate 102, a working electrode conductive substrate arranged on the working electrode flexible substrate 102, and The glucose oxidase loaded on the conductive substrate of the working electrode, the conductive substrate of the working electrode and the glucose oxidase form a graphene / carbon nanotube / glucose oxidase composite fiber fabric 101, and the opposite electrode 2 includes a flexible substrate 202 of the opposite electrode, which is located on the opposite electrode The opposite electrode conductive substrate on the flexible substrate 202 and the silver / silver chloride film plated on the opposite electrode conductive substrate, the opposite electrode conductive substrate and the silver / silver chloride film form g...

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Abstract

The invention relates to a biological non-destructive blood sugar detection device and a preparation method thereof. The device includes a working electrode and a counter electrode. The working electrode includes a working electrode flexible substrate, a working electrode conductive substrate arranged on the working electrode flexible substrate, and a working electrode conductive substrate loaded on the working electrode. The glucose oxidase on the substrate, the counter electrode comprises a counter electrode flexible substrate, a counter electrode conductive substrate arranged on the counter electrode flexible substrate, and a silver / silver chloride film plated on the counter electrode conductive substrate. The specific preparation method is as follows: firstly obtaining a graphene / carbon nanotube composite fiber fabric, then taking two graphene / carbon nanotube composite fiber fabrics, respectively loading glucose oxidase to obtain a working electrode, and plating silver / silver chloride film to obtain a pair of graphene / carbon nanotube composite fabrics. electrodes, and finally the working and counter electrodes are placed side by side. Compared with the prior art, the present invention establishes the relationship between the simulated interstitial fluid and the immediate response current through the two-electrode system, which can detect the change of the blood glucose concentration of the organism with high sensitivity.

Description

technical field [0001] The invention belongs to the technical field of blood sugar detection, and in particular relates to a biological nondestructive blood sugar detection device and a preparation method thereof. Background technique [0002] According to relevant reports, the number of diabetic patients in the world will reach 400 million in 2030, which means that more and more people will be affected by this chronic disease, including its complications. For such patients, the current method of accurately detecting blood glucose is mainly through venous blood sampling, but this method not only cannot continuously detect changes in blood glucose, but also seriously affects the quality of life of patients and compliance with long-term monitoring. Therefore, how to build a continuous , Accurate, nondestructive blood glucose detection is an urgent problem to be solved at present. [0003] So far, the reported non-invasive blood glucose detection devices for human body are mai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/1486H01B1/04
CPCA61B5/14532A61B5/1486A61B2562/125A61B2562/164H01B1/04
Inventor 陈涛姚瑶吕甜
Owner TONGJI UNIV
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