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Anti-oxidative stress oral composite resin taking MitoQ nanoparticles as filler and preparation method of anti-oxidative stress oral composite resin

An anti-oxidative stress, nanoparticle technology, applied in dental preparations, pharmaceutical formulations, medical science and other directions, can solve the problems of oral tissue oxidative stress damage, polymerization heat generation and incomplete polymerization, polymerization shrinkage and other problems

Inactive Publication Date: 2020-10-27
温州医科大学附属口腔医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current composite resin products still have certain deficiencies: polymerization shrinkage, polymerization heat generation and incomplete polymerization
However, there is currently no method that can well solve the oxidative stress damage of oral tissue caused by resin monomers.

Method used

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  • Anti-oxidative stress oral composite resin taking MitoQ nanoparticles as filler and preparation method of anti-oxidative stress oral composite resin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation method of anti-oxidative stress oral cavity composite resin with MitoQ nanoparticles as filler

[0035] Step 1. Construct MitoQ nanoparticles:

[0036] (1) Hyaluronic acid is added to ultrapure water to prepare a concentration of 3mg / mL, and stirred until completely dissolved;

[0037] (2) Dissolve MitoQ in DMSO under ultrasonic treatment to adjust the concentration to 24mg / mL;

[0038] (3) Add the MitoQ / DMSO solution dropwise to the hyaluronic acid solution to form a MitoQ / HA solution with a concentration of 0.18mg / mL;

[0039] (4) Dialyze with a dialysis bag with a molecular weight cut-off of 8000Da for 2 hours to remove a small amount of DMSO, and sterilize at 121°C to obtain Mito Q / HA nanoparticles.

[0040] Step 2. Disperse and mix Mito Q / HA nanoparticles and inorganic glass powder under ultrasound. The glass powder is divided into 0.4um and 2um diameters. The configuration is that 0.4um glass powder accounts for 65wt% of the total weight, a...

Embodiment 2

[0043] Example 2 Preparation method of anti-oxidative stress oral cavity composite resin with MitoQ nanoparticles as filler

[0044] The difference from Example 1 is that the specific gravity of 2um glass powder, 0.4um glass powder and MitoQ NP is different. Select 0.4um glass powder to account for 60wt% of the total weight, 2um glass powder to account for 15wt% of the total weight, and MitoQ NP to account for 60% of the total weight 10 wt%.

Embodiment 3

[0045] Example 3 Preparation method of anti-oxidative stress oral cavity composite resin with MitoQ nanoparticles as filler

[0046] The difference from Example 1 is that the specific gravity of 2um glass powder, 0.4um glass powder and MitoQ NP is different. Select 0.4um glass powder to account for 55wt% of the total weight, 2um glass powder to account for 15wt% of the total weight, and MitoQ NP to account for 50% of the total weight. 15 wt%.

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Abstract

The invention discloses anti-oxidative stress oral composite resin taking MitoQ nanoparticles as filler and a preparation method of the anti-oxidative stress oral composite resin. The resin is prepared from the components in parts by weight as follows: 79.5-89.9 parts of MitoQ / inorganic nanoparticles, 10-20 parts of a resin matrix and 0.1-0.5 part of an additive. MitoQ is integrated into the resinmatrix, when the oral composite resin is used as an oral filling material, residual monomers are reduced, and damage to oral tissue by the resin monomers is relieved.

Description

technical field [0001] The invention relates to the technical field of oral filling materials, in particular to an anti-oxidative stress oral cavity composite resin using MitoQ nanoparticles as a filler and a preparation method thereof. Background technique [0002] Oral composite resin is a filler-reinforced composite material. Because of its easy operation, beautiful color and superior performance, it is widely used in tooth defects caused by caries and trauma. It has become the most widely used material for tooth filling. Composite resin is a polymer composite material mixed with specially treated inorganic fillers and bifunctional acrylate resins (such as TEGDMA). It is cured at room temperature with the help of chemical or photoinitiating systems to form a composite material with certain mechanical properties and aesthetic properties. Resin body, to meet the clinical needs. Its main components are resin monomers, inorganic fillers, activated diluents, initiators, accel...

Claims

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Application Information

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IPC IPC(8): A61K6/898A61K6/836A61K6/889
Inventor 潘乙怀黄盛斌虞其豪林森
Owner 温州医科大学附属口腔医院
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