Unlock instant, AI-driven research and patent intelligence for your innovation.

Production method for a suspension drug

A production method and suspension technology, applied in drug combination, pharmaceutical formula, liquid delivery, etc., can solve problems such as drug hardening

Active Publication Date: 2020-10-27
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention intends to provide a production method for suspension medicine, which uses swollen sodium alginate as a thickener and suspending agent to solve the problem of easy precipitation and separation of iodoxanamide suspension. The technical problem that the drug is easy to harden after the layer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Production method for a suspension drug
  • Production method for a suspension drug
  • Production method for a suspension drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of iodother amylamine suspension

[0029] The formula of iodoxanamide suspension is: every 100L suspension drug contains 2kg iodoxanamide (oral grade, CASNO.22662-39-1), 225g sodium alginate (analytical pure, CAS NO.9005- 38-3), 10kg Tween-80 (analytical grade, CASNO.9005-65-6), 100g citric acid (oral grade, CAS NO.77-92-9), 100g sodium citrate (oral grade, CASNO. 68-04-2), 3L soybean oil (food grade, CAS NO.8001-22-7), 7L dimethyl silicone oil (food grade, CASNO.9006-65-9), 1000ml benzyl alcohol (analytical grade, CAS NO.100-51-6), the balance is water (distilled water or water for injection). The sodium alginate used in this program is a polymer material, and it is necessary to check the viscosity of sodium alginate according to the requirements of "GB 1886.243-2016 National Food Safety Standard Food Additive Sodium Alginate". The viscosity of sodium alginate can be used in this formula if the viscosity is between 600-800 .

[0030] Th...

Embodiment 2

[0037] Example 2 is basically the same as Example 1, except that the formula components are changed (as shown in Table 1), and when making the sodium alginate solution, 70°C water is used to swell the sodium alginate for 2 hours. Embodiment 3-Embodiment 5 are basically the same as Embodiment 1, the difference lies in the adjustment of formula and process parameters, see Table 1 for details.

[0038] Comparative Example 1-Comparative Example 5 are basically the same as Example 1, the difference lies in the adjustment of formula and process parameters, see Table 2 for details. In comparative example 1-comparative example 5, the suspension agent (thickening agent) such as sodium carboxymethyl cellulose, xanthan gum (combined with dextran-70), starch (coordinated with dextran-20), polyethylene glycol and dextran The dosages are the optimal dosages obtained after many experiments and tests.

experiment example 1

[0048] Sedimentation volume ratio: Refer to the detection method of sedimentation volume ratio in "Chinese Veterinary Pharmacopoeia" 2015 Edition 0111 Oral Solution, Oral Suspension, and Oral Emulsion to detect the sedimentation volume of Examples 1-5 and Comparative Examples 1-12 ratio (each embodiment or comparative example is provided with 10 repetitions, n=10), the sedimentation volume ratio of specified settling time (this experimental example adopts 3h, 24h, 48h and 7 days, four kinds of settling time) is bigger, shows that mixed The better the suspension effect and the more stable the suspension, the experimental results are shown in Table 4-Table 6.

[0049] Detection of redispersion: get the suspension 500ml in the above-mentioned embodiment and comparative example, place in the sample bottle (do not set repeated experiment), let stand for three months (all appear different degrees of stratification), then turn the sample bottle upside down , observe how many times th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of veterinary drug production, in particular to a production method for a suspension drug. The method comprises the following steps of (1) preparing a suspending aid: dissolving and swelling sodium alginate in water to obtain a sodium alginate solution; and (2) mixing components: mixing and homogenizing rafoxanide, an auxiliary agent and the sodium alginate solution in the water. According to the method, swollen sodium alginate is used as a thickening agent and the suspending aid, so that the technical problems that a rafoxanide suspension is easy to precipitate and layer and the drug is easy to harden after layering are solved. The scheme can be applied to the production of the rafoxanide suspension and the treatment of diseases such as livestock fasciola hepatica.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine production, in particular to a production method for suspension medicine. Background technique [0002] Iodosanamide is off-white to brown powder, soluble in acetone, slightly soluble in chloroform or ethyl acetate, slightly soluble in methanol, insoluble in water. Iodoxanamide is an anti-helminthic veterinary drug with anti-fasciola hepatica effect. It transports cations across the cell membrane and has an uncoupling effect on the oxidative phosphorylation process of the mitochondria of the parasite, thereby affecting the energy metabolism process of the parasite. , causing the death of the worm. For the convenience of administration, iodoxanamide is usually prepared in the form of suspension for oral administration by animals. In addition to being convenient for feeding animals in the form of the suspension, the bioavailability of the drug in the suspension is higher, and the drug ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/609A61K47/36A61K47/44A61K47/34A61K47/12A61P33/10
CPCA61K9/10A61K31/609A61K47/36A61K47/44A61K47/34A61K47/12A61P33/10Y02A40/70
Inventor 卢朝成廖成斌吴仕炜刘圣梅
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM