A method for passive regulation of biological tissue temperature field based on optical phase change nanoparticles

A nanoparticle and biological tissue technology, applied in the field of tumor photothermal therapy, to achieve effective treatment, reduce photothermal conversion efficiency, and reduce damage

Active Publication Date: 2022-03-01
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problem of how to reduce the damage range of normal biological tissues while ensuring the effectiveness of thermal therapy in tumor photothermal therapy, and to provide a method for passively regulating the temperature field of biological tissues based on optical phase change nanoparticles

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  • A method for passive regulation of biological tissue temperature field based on optical phase change nanoparticles
  • A method for passive regulation of biological tissue temperature field based on optical phase change nanoparticles
  • A method for passive regulation of biological tissue temperature field based on optical phase change nanoparticles

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specific Embodiment approach 1

[0017] Specific Embodiment 1: In this embodiment, a method for passively regulating the temperature field of biological tissues based on optical phase-change nanoparticles is completed according to the following steps:

[0018] 1. Select nanoparticles of different sizes, shapes and types whose crystallization temperature is between 40°C and 100°C and whose dielectric constant changes before and after the phase transition as the nanoparticles that meet the requirements;

[0019] 2. Draw the absorption factor Q of the qualified nanoparticles before and after the phase transition in step 1 abs The graph of the change with the laser wavelength, if there is a band where the absorption factor of the nanoparticle after the phase transition is lower than that of the nanoparticle before the phase transition, then the nanoparticle is a qualified nanoparticle;

[0020] 3. Draw a graph of the absorption factor of the nanoparticle surface coating that meets the requirements in step 2 befor...

specific Embodiment approach 2

[0025] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the different sizes mentioned in step 1 are equivalent radius of 20-100 nm.

[0026] Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0027] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the different shapes described in Step 1 are nanospheres, nanorods, nanotriangular sheets or nanocages.

[0028] Other steps are the same as those in Embodiment 1 or 2.

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Abstract

The invention relates to a method for passively regulating the temperature field of biological tissues based on optical phase-change nanoparticles, which relates to the technical field of tumor photothermal therapy. The purpose of the present invention is to solve the problem of how to reduce the damaged range of normal biological tissues while ensuring the effectiveness of thermal therapy in tumor photothermal therapy. Method: Calculate the absorption factor Q of qualified nanoparticles before and after phase transition abs With the change of the laser wavelength, further select the nanoparticles that meet the requirements; calculate the change of the absorption factor of the nanoparticle surface coating before and after the phase transition with the laser wavelength, and select the nanoparticles that meet the requirements again; calculate the quality factor P of the nanoparticles , select the nanoparticle with the largest quality factor as the phase change material required for laser-induced tumor hyperthermia. The invention can obtain a passive regulation technology of the biological tissue temperature field based on the optical phase change nanoparticles.

Description

technical field [0001] The invention relates to the technical field of tumor photothermal therapy, in particular to a method for passively regulating the temperature field of biological tissues based on optical phase transition nanoparticles. Background technique [0002] Traditional cancer therapy includes surgery, radiotherapy and chemotherapy. Surgical resection is usually difficult to remove all tumors. At the same time, some patients cannot undergo surgery due to various reasons. Chemotherapy and radiotherapy have serious side effects. Therefore, in recent years, tumor hyperthermia technology has received more and more attention as a tumor replacement therapy, among which photothermal therapy using laser heating to treat tumors has been developed rapidly. This technology mainly uses specifically targeted nanoparticles to gather in the tumor area, so as to convert light energy into heat energy more efficiently, increase the temperature of the tumor area, kill cancer cell...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N5/06
CPCA61N5/062A61N2005/0626
Inventor 任亚涛齐宏陈琴姚港李华欣
Owner HARBIN INST OF TECH
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