The invention provides a
system (1) for fluid manipulation, wherein the
system (1) comprises a first liquid supply (10), a second liquid supply (20), a microfluidic device (100), a
cavitation induction system (200), and a
control system (300), wherein: the first liquid supply (10) is configured to provide a first liquid (15) to the microfluidic device (100); the second liquid supply (20) is configured to provide a second liquid (25) to the microfluidic device (100); the microfluidic device (100) comprises a hosting chamber (110), wherein the hosting chamber (110) has a chamber length (L) defined by a first chamber end (111) and a second chamber end (112), wherein the hosting chamber (110) has an average equivalent circular
diameter (D) perpendicular to the length (L), wherein L ≥ 3*D; wherein the
cavitation induction system (200) is selected from the group comprising a
laser-based
heating system, an
electric discharge system, and a heater; and wherein the
control system (300) is configured to control the first liquid supply (10), the second liquid supply (20), and the
heating system (200), and wherein the
control system (300) has an operational mode wherein: in a
preparation stage the first liquid supply (10) and the second liquid supply (20) are configured to provide a liquid multilayer (400) in the hosting chamber (110), wherein the liquid multilayer (400) comprises n
layers (450) sequentially arranged along the chamber length (L), wherein n ≥ 2, wherein adjacent
layers (450) are distinct phases, and wherein the
layers (450) comprise a first
liquid layer (415) comprising the first liquid (15) arranged adjacent to a second
liquid layer (425) comprising the second liquid (25); and in a
cavitation stage the cavitation
induction system (200) is configured to induce cavitation of the first liquid (15) at a first location (41), wherein the first location (41) is arranged in the first
liquid layer (415).