External ointment for treating hyperplasia of mammary glands and preparation method thereof
A technology for topical plasters and plasters, applied in the direction of medical preparations with no active ingredients, medical preparations containing active ingredients, ointment delivery, etc., which can solve the problems of high cost, complex ingredients, cumbersome preparation methods, etc., so that it is not easy to repeat , the effect of not easy to relapse
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Embodiment 1
[0028] An external ointment for treating mammary gland hyperplasia, which is made of active ingredients and a matrix, the active ingredients are extracted from the following traditional Chinese medicines in parts by weight: 50 parts of nuxychoxylum, 25 parts of curcuma, 40 parts of cloves and 25 parts of borneol; the matrix The ingredients are glycerin, gelatin, water, PEG6000 and carbomer, and the mass ratio is 18:8.5:2:5:3; the mass ratio of the active ingredient to the matrix is 3:7.
[0029] The preparation method of described external ointment is:
[0030] S1. Preparation of ethanol extract: take the nuxychonzi and cloves in the weight portion and grind them into coarse powder, add 10 times the mass of 95% ethanol, soak for 1 hour, heat and extract for 1.5 hours, and filter to obtain ethanol extract and dregs Recover the ethanol in the alcohol extract under reduced pressure, concentrate to the extract A with a relative density of 1.30~1.35 (60°C), and set aside;
[003...
Embodiment 2
[0035] An external ointment for treating mammary gland hyperplasia, its composition and preparation method are similar to Example 1, the difference is that the active ingredient is extracted from the following traditional Chinese medicines in parts by weight: 100 parts of Nuxynum, 50 parts of Curcuma, 80 parts of Clove And 50 parts of borneol.
Embodiment 3
[0037] An external ointment for treating mammary gland hyperplasia, its composition and preparation method are similar to those of Example 1, the difference is that the active ingredient is extracted from the following traditional Chinese medicines in parts by weight: 200 parts of Nuxynum, 100 parts of Curcuma, 160 parts of Clove And 100 parts of borneol.
[0038] Toxicology experiment:
[0039] 1. Acute skin toxicity test
[0040] Get 20 SPF level experimental rabbits, body weight about 2kg, half male and half male, divided into blank control group (substrate 10.0g / ), the experimental group is the external application ointment of the present invention: intact skin and damaged skin, each 2 doses: medication (10.0g / piece, 2g / piece), 5 pieces in each group. Depilate the two sides of the back spine of the rabbit, and the depilated area is about 12cmx15cm. Check whether the depilated skin is injured 24 hours after depilation. Injured rabbits are not suitable for toxicity tes...
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