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Somatotropin releasing peptide

A growth-promoting hormone and residue technology, applied in the field of use in diseases, can solve the problems of easy decomposition, high cost, difficult process control, etc., and achieve the effects of simple molecular structure, difficult decomposition, and process control.

Inactive Publication Date: 2003-08-27
HUBEI YANGFAN HLDG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In diseases or conditions requiring increased levels of growth hormone, the proteinaceous nature of growth hormone currently dictates parenteral administration only
In addition, other direct-acting natural secretagogues (such as GHRH and PACAP) are high molecular weight polypeptides and therefore can only be administered parenterally
After retrieval, the 96194947.3 patent application is the latest technology of this type of compound, but its molecule is large and easy to decompose, and it can only be administered parenterally, and must use solid-phase synthesis method, which is not only difficult to control the process, but also has low yield and high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] The structural formula of the embodiment of the compound of the present invention is as follows:

[0012] Aib-D-Trp-D-Pro-3-Methylpiperidine

[0013] Now with Aib-D-Trp-D-Pro-3-Methylpiperidine

[0014] α-Amino-isobutyryl-D-tryptophanyl-D-prolyl-3-methylpiperidine is an example to describe its production method:

[0015] Transfer 1mmol of DBP into a 100ml round bottom flask, add 30ml of anhydrous CH 2 CL 2 , and then add 1 mmol HOBT, while stirring with nitrogen under ice-bath conditions.

[0016] Dissolve 1.05 mmol WSC HCL into 10 ml anhydrous CH 2 CL 2 , and then quickly added to the preceding solution. Dissolve 1.1 mmol of MP in 10 ml of anhydrous CH 2 CL 2 solution, and added dropwise to the aforementioned mixed solution, and the reaction mixture was stirred at room temperature for more than 18 hr.

[0017] After the reaction, the reaction mixture was washed with 20ml 20% citric acid aqueous solution, 20ml NaHCO 3 Wash with saturated aqueous solution and...

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PUM

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Abstract

The present invention provides a somatotropin releasing peptoid, including compounds in general formula or its pharmaceutically-acceptable salt and its composite. Said peptoid is used for promoting animal and human growth.

Description

technical field [0001] The present invention relates to a growth hormone releasing peptide, which is a new peptide derivative, including their composition, and their use in treating diseases caused by growth hormone deficiency. Analogues belonging to peptides. Background technique [0002] Growth hormone is a hormone that stimulates tissue growth. Growth hormone is known to have numerous effects on metabolic processes (eg, stimulation of protein synthesis and mobilization of free fatty acids) and to cause a metabolic shift in energy from carbohydrate to fatty acid metabolism. Growth hormone deficiency can lead to serious diseases such as dwarfism. [0003] Growth hormone is released from the pituitary gland, directly or indirectly, under the tight control of several hormones and neurotransmitters. Growth hormone release can be stimulated by somatoreleasing hormone (CHRH) and inhibited by somatostatin. In both cases, the hormones are released from the hypothalamus, but th...

Claims

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Application Information

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IPC IPC(8): A61K38/05C07K5/065
Inventor 徐进
Owner HUBEI YANGFAN HLDG CO LTD
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