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Medical device

A technology for medical use and equipment, applied in biochemical equipment and methods, medical science, pharmaceutical formulations, etc., can solve the problems of increased non-specific adsorption, poor detection accuracy, and dissolution of solidified layer components, so as to achieve the reduction of dissolved substances Effect

Inactive Publication Date: 2020-11-13
ASAHI GLASS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there is a problem in the biochip that if non-specific proteins other than the biogenic substance to be detected are adsorbed on the part where the molecules for capturing the biogenic substance are not immobilized, it becomes noise during detection and the detection accuracy deteriorates.
[0005] However, the above-mentioned conventional method has the following problems: the amount of non-specific adsorption increases when the biochip is used for a long time, and the components of the solidified layer are eluted to deteriorate the detection accuracy.

Method used

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Examples

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Embodiment

[0186] Examples are shown below to describe the present invention in detail. However, the present invention is not limited by the following description. Unless otherwise stated, "%" means "mass %". Examples 1-6 and Examples 13-14 are examples, and Examples 7-12 are comparative examples.

[0187] (Synthesis and preparation of compound (X))

[0188]

[0189] Compounds belonging to compound (X1) and compounds having no bioaffinity group used in Comparative Examples were synthesized or prepared as follows.

[0190] Compound (X11-1); as the compound (X11-1) of the structure shown below, that is, 2-[methoxy(polyoxyethylene) 9-12 Propyl]trimethoxysilane was prepared as a commercial item SIM6492.72 (trade name, manufactured by Gelest Corporation). Compound (X11-1) is that the terminal hydrogen atom of compound (X11) is replaced by a methyl group, n1 is 9-12, Q 1 for-C 3 h 6 -, t is 3, R 8 For methyl compounds.

[0191]

[0192] Compound (X11-2); the compound (X11-2) havi...

manufacture example 1

[0209] Add HEMA 57.0g (438mmol), KBM-503 3.00g (12.1mmol), 1-methoxy-2-propanol 119g, diacetone alcohol 21g, and 2,2'-azo to a 500mL 3-neck flask Dimethyl bis(2-methylpropionate) 600 mg (2.61 mmol). The monomer concentration in the reaction liquid was 30% by mass, and the initiator concentration was 1% by mass. Next, the obtained mixture was stirred at 75° C. under a nitrogen atmosphere for 16 hours, and then left to cool to room temperature to obtain a colorless transparent liquid (a solution containing 30% by mass of the copolymer (X21-1)). The yield was 200 g, and the yield was 100%.

manufacture example 2～4

[0211] In Production Example 1, copolymers (X21-2) and (X21-3) were produced in the same manner except that the monomer composition was changed as shown in Table 2. In addition, homopolymers (M) of monomers having biocompatible groups are produced.

[0212] Mw of the compound (copolymer) obtained in Production Examples 1 to 4, (CH in group 1 (4) 2 CH 2 O), the number of repetitions (n2), the ratio (mass %) of the bioaffinity group (group 1 (4)) in the compound, and the ratio (mass %) of the alkoxysilyl group are shown in Table 2 .

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Abstract

Provided is a medical device which has a reduced non-specific absorption amount, which has excellent durability of said reduction, and which has reduced eluates from the surface layer. The medical device has a device substrate, and a surface layer positioned on at least part of the surface of the device substrate that comes into contact with water. At least part of the surface of the device substrate is made from an inorganic material, and the surface layer is made from a cured product of a compound having a biocompatible group and an alkoxy silyl group. The content of the biocompatible groupin the compound falls within the range of 25 to 83% by mass, inclusive, and the content of the alkoxy silyl group falls within the range of 2 to 70% by mass, inclusive.

Description

technical field [0001] The present invention relates to medical equipment. Background technique [0002] Conventionally, a method using a biochip is known as an analysis method of a biologically derived substance. In this method, molecules for capturing specific biogenic substances (proteins, etc.) are immobilized on the chip surface, and the biogenic substances captured by the molecules are detected. [0003] However, there is a problem in the biochip that if non-specific proteins other than the biogenic substance to be detected are adsorbed on the part where the molecules for capturing the biogenic substance are not immobilized, it becomes noise during detection and the detection accuracy deteriorates. . [0004] Therefore, as a method of reducing the amount of non-specific protein adsorption (non-specific adsorption amount), it is proposed to form a compound containing 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate on the substrate. (For exampl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543C03C17/30G01N33/53G01N37/00C12M1/00
CPCC03C17/30G01N33/53G01N37/00C12M1/00G01N33/543A61L31/10A61L29/085A61L27/34C08L33/14C08F230/08C08L33/06C08F220/20A61L31/026A61L2400/18C08L33/08
Inventor 小口亮平江口创山本今日子
Owner ASAHI GLASS CO LTD
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