Preparation method of reduced graphene oxide silk fibroin composite membrane

Abstract

The invention discloses a preparation method of a reduced graphene oxide silk fibroin composite membrane. The method involves hollow nanoparticles, a polymer matrix and a catheter wall main body, wherein the catheter wall main body is composed of the hollow nanoparticles and the polymer matrix, and the hollow nanoparticles are uniformly distributed in the polymer matrix. According to the method, an interventional medical catheter wall structure applied to mild hypothermia brain protection treatment is a brand-new medical interventional catheter wall structure, a nano hollow material is introduced into a medical interventional catheter wall, the heat conductivity coefficient of a catheter material is reduced, a heat preservation and insulation medical catheter is prepared, and by adding thehollow nanoparticles in the catheter wall, the purpose of reducing the heat conductivity coefficient of the catheter is achieved; and by regulating and controlling the volume fraction of the hollow nanoparticles in the catheter wall, the interventional catheter with the required heat conductivity coefficient is obtained, and the hollow nanoparticles are all biological inert materials and have good biocompatibility, and cannot generate toxicity to a human body and cannot cause inflammation and immunoreaction after being intervened into the human body.

Description

technical field [0001] The invention relates to the technical field of medical material preparation, in particular to a method for preparing a reduced graphene oxide silk fibroin composite film. Background technique [0002] Silk fibroin is a natural polymer fibrous protein obtained after silkworm degumming, mainly composed of glycine, alanine, serine and tyrosine (accounting for more than 95% of the total), as a natural active protein, silk fibroin The application of protein in the field of biomedical materials and tissue engineering has received more and more attention. It has the following advantages: 1. Good biocompatibility, silk fibroin has low immunogenicity and good biocompatibility , biodegradability, can promote the adhesion and proliferation of bone cells; 2 good mechanical properties, silk fibroin is recognized as a natural biomaterial with superior mechanical properties, the limit pull of natural silk (including sericin) The tensile strength is as high as 500MP...

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above technical problems, the present invention provides a method for preparing a reduced graphene oxide silk fibroin composite film, so as to solve the problems of poor mechanical properties and low osteogenic activity of the silk fibroin film obtained in the prior art

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