Gold nanoparticles with uniform particle size extracted based on sodium citrate reduction method and preparation method of gold nanoparticles

A technology of nano-gold particles and sodium citrate, which is applied in nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve the problems of cytotoxicity, poor repeatability, and uncontrollable particle size, etc., to achieve Simple operation and reproducible results

Pending Publication Date: 2020-11-17
NORTHWEST UNIVERSITY FOR NATIONALITIES
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Problems solved by technology

[0005] At present, the research on the preparation of regular gold nanoparticles is in the exploratory stage. The drawbacks of the gold nanoparticles prepared by the existing methods are mainly poor reproducibility, uncontrollable particle size, poor dispersion, poor stability and cytotoxicity.

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  • Gold nanoparticles with uniform particle size extracted based on sodium citrate reduction method and preparation method of gold nanoparticles
  • Gold nanoparticles with uniform particle size extracted based on sodium citrate reduction method and preparation method of gold nanoparticles

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Embodiment Construction

[0023] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0024] A kind of preparation method based on the sodium citrate reduction method of the present invention extracts the nano-gold particles with uniform particle size, comprises the following steps:

[0025] 1) Get 6 250ml Erlenmeyer flasks, number them in the order of numbers 1-6, add ultrapure water 200ml and 1% chloroauric acid 2ml respectively in each conical flask; make the final concentration of chloroauric acid solution in each bottle 0.01%;

[0026] 2) Put 6 Erlenmeyer flasks into a 500W electric furnace and heat them for 5 minutes, and take them out after the liquid in the flasks boils; immediately add 1% sodium ci...

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Abstract

The invention discloses gold nanoparticles with uniform particle size extracted based on a sodium citrate reduction method and a preparation method of the gold nanoparticles. According to the preparation method, on the basis of an experiment of preparing gold nanoparticles by a classic sodium citrate reduction method, an electric furnace is selected for heating, 1% PVP is used as a protective agent, and the dosage of a 1% sodium citrate reducing agent is controlled within a range of 12-16ml; and the gold nanoparticles prepared under the condition is uniform in particle size, the particle sizeis 18 +/-2 nm, the gold nanoparticles prepared through the preparation method has the advantages of being good in dispersity, good in stability and free of cytotoxicity, and the method is easy to operate and high in repeatability.

Description

technical field [0001] The invention relates to the technical field of nanomaterial preparation, and more specifically relates to a method for extracting gold nanoparticles with uniform particle diameters based on a sodium citrate reduction method and a preparation method thereof. Background technique [0002] Nanogold refers to tiny particles of gold with a diameter of 1-100nm. It has high electron density, dielectric properties and catalytic effect, and can combine with various biological macromolecules without affecting its biological activity. Gold nanoparticles of various particle sizes can be conveniently prepared by the reduction method from chloroauric acid, and its color is red to purple depending on the diameter. Nanogold labeling technique, one of the four major modern labeling techniques, is essentially a coating process in which polymers such as proteins are adsorbed to the surface of gold nanoparticles. The adsorption mechanism may be that the negative charge ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y40/00B82Y30/00
CPCB22F9/24B82Y40/00B82Y30/00B22F1/054
Inventor 王东敏金寿瑞王永刚马佩芬马婧张兰兰班雨婷
Owner NORTHWEST UNIVERSITY FOR NATIONALITIES
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