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Preparation method of scopolamine alkaloid in przewalskia tangutica maxim

A technology of horse urine foam and tropane, applied in the field of preparation of tropane alkaloids, to achieve the effect of simple and convenient process operation, strong activity and high extraction efficiency

Pending Publication Date: 2020-11-20
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the research on horse urine foam is mainly for its chemical composition analysis and the content determination of tropane alkaloids. There is no report about the extraction of tropane alkaloids from horse urine foam. Therefore, it is urgent to establish a tropane alkaloid The extraction process of alkaloids to meet the application of tropane alkaloids in the pharmaceutical and chemical industry

Method used

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  • Preparation method of scopolamine alkaloid in przewalskia tangutica maxim
  • Preparation method of scopolamine alkaloid in przewalskia tangutica maxim
  • Preparation method of scopolamine alkaloid in przewalskia tangutica maxim

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Embodiment 1

[0019] Embodiment 1, preparation of tropane alkaloids in horse urine foam

[0020] Take 1000g of horse urine bubble root, crush it, add 20000ml of 4% methanol solution of acetic acid, and ultrasonically extract for 30min under the condition of power of 2000w. Membrane separation and purification, the solution passing through the organic membrane is dried to obtain tropane alkaloids.

Embodiment 2

[0021] Embodiment 2, preparation of tropane alkaloids in horse urine foam

[0022] Take 200 g of horse urine soaked root, crush it, add 5000 ml of 4% acetic acid methanol solution, heat reflux extraction for 2 hours, the extraction temperature is 70 ° C, the extract is filtered through a 0.2 μm ceramic membrane to remove impurities, and the filtrate is filtered through a filter with a molecular weight cut-off of 5000 Daltons. Organic membrane separation and purification, after the solution passing through the organic membrane is dried, tropane alkaloids can be obtained.

Embodiment 3

[0023] Embodiment 3, preparation of tropane alkaloids in horse urine foam

[0024] Take 100g of horse urine soaked root, crush it, add 1000ml of 4% acetic acid methanol solution, heat reflux extraction for 2.5h, the extraction temperature is 75°C, the extract is filtered through a 0.2μm ceramic membrane to remove impurities, and the filtrate is passed through a filter with a molecular weight of 5000 Daltons. Organic membrane separation and purification, after the solution passing through the organic membrane is dried, tropane alkaloids can be obtained.

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Abstract

The invention discloses a preparation method of scopolamine alkaloid in przewalskia tangutica maxim, which comprises the following steps: taking przewalskia tangutica maxim, pulverizing, adding an acetic acid-methanol solution, extracting, filtering the extracting solution by a ceramic membrane to remove impurities, separating by an organic membrane to remove impurities, and drying the water solution penetrating through the organic membrane to obtain the product. The preparation method of the scopolamine alkaloid in the przewalskia tangutica maxim is high in extraction efficiency, simple and convenient in technological operation and suitable for industrialized mass production, and the scopolamine alkaloid obtained through the preparation method is high in content and high in activity and can meet the application of the scopolamine alkaloid in the pharmaceutical and chemical industries.

Description

technical field [0001] The invention specifically relates to a preparation method of tropane alkaloids in horse urine foam. Background technique [0002] Horse urine bubble is a Solanaceae plant, also known as Tangut horse urine bubble. It is a rare and endangered plant unique to our country, distributed in Qinghai, Tibet, Sichuan and other places. It is a commonly used medicine in Tibetan medicine. Its roots, seeds and whole plant can be used for medicinal purposes. It has analgesic, antispasmodic, insecticidal and anti-inflammatory effects. It is used to treat gastrointestinal spasms, diphtheria, anthrax and other diseases. The main active ingredients of horse urea are scopolane alkaloids, such as atropine, scopolamine, anisodamine, anisodine, etc. These compounds have the effect of blocking acetylcholine receptors, dilating microvessels, improving microcirculation and anti-shock. [0003] At present, the research on horse urine foam is mainly for its chemical compositio...

Claims

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Application Information

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IPC IPC(8): C07D451/10A61P43/00
CPCC07D451/10A61P43/00
Inventor 周国英陈晨吴庆江
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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