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Medicine for abstinence treatment of alprazolam dependent anxiety insomnia

An alprazolam, dependent technology, applied in the field of traditional Chinese medicine preparation, can solve problems such as troubles and affect life, and achieve the effects of reducing the incidence rate, using the drug safely, and improving clinical symptoms

Active Publication Date: 2020-11-24
赵雪杉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the dependence on benzodiazepines has always troubled and affected people's lives.

Method used

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  • Medicine for abstinence treatment of alprazolam dependent anxiety insomnia
  • Medicine for abstinence treatment of alprazolam dependent anxiety insomnia
  • Medicine for abstinence treatment of alprazolam dependent anxiety insomnia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Raw material prescription: Bupleurum 1.2kg, Scutellaria baicalensis 1.5kg, perilla 1.5kg, Sichuan pepper 0.6kg, cassia twig 1kg, jujube seed 3kg, raw oyster 3kg, raw gypsum 3kg, vine 1.5kg, Albizia julibrissin 1.5kg, Codonopsis 3kg, licorice 0.6kg, jujube 2kg.

[0025] According to the dosage of the above-mentioned prescription, other raw medicines except Codonopsis pilosula were extracted with water for 3 times, water 10 times the weight of the raw medicine was added each time, decocted for 3 hours, the decoction liquid was combined, filtered, and the filtrate was concentrated to a relative density of 1.20( 70~80℃) extract.

[0026] Codonopsis pilosula is crushed into fine powder, added to the above-mentioned extract, mixed uniformly, vacuum-dried at 80° C., crushed and passed through a 65-mesh sieve to obtain a fine powder of the active ingredient of the medicine.

[0027] Add 2 times its weight of dextrin and 1 times its weight of powdered sugar to the fine powder o...

Embodiment 2

[0029] Bupleurum 1.5kg, Scutellaria baicalensis 1kg, perilla 2kg, Sichuan pepper 0.4kg, cinnamon twig 1.2kg, jujube seed 4kg, raw oyster 2.5kg, raw gypsum 3kg, vine 1.2kg, Albizia julibrissin 1.8kg, Codonopsis 2.5kg, licorice 0.8kg, jujube 2.5kg.

[0030] According to the dosage of the above-mentioned prescription, extract other raw materials except Codonopsis Codonopsis with water twice, add water 8 times the weight of the raw materials each time, decoct for 3 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20 ( 70~80℃) extract.

[0031] Codonopsis pilosula is crushed into fine powder, added to the above-mentioned extract, mixed uniformly, vacuum-dried at 80° C., crushed and passed through a 65-mesh sieve to obtain a fine powder of the active ingredient of the medicine.

[0032] Add dextrin twice its weight to the fine powder of the active ingredient of the drug, mix well, use 95% ethanol as a wetting agent to make a soft material,...

Embodiment 3

[0034] Bupleurum 1kg, Scutellaria baicalensis 2kg, perilla 1.2kg, Sichuan pepper 0.6kg, cassia twig 1.2kg, jujube seed 2.5kg, raw oyster 4kg, raw gypsum 2kg, vine 2kg, Albizia julibrissin 1kg, Codonopsis 3kg, licorice 0.4kg, Jujube 2kg.

[0035] According to the dosage of the above formula, extract other raw materials except Codonopsis Codonopsis with water for 3 times, add water 12 times the weight of the raw materials each time, decoct for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25 (70~80℃) extract.

[0036] Codonopsis pilosula is crushed into fine powder, added to the above-mentioned extract, mixed uniformly, vacuum-dried at 80° C., crushed and passed through a 65-mesh sieve to obtain a fine powder of the active ingredient of the medicine.

[0037] Add 200g dextrin, 50g microcrystalline cellulose, 50g low-substituted hydroxypropyl cellulose and an appropriate amount of magnesium stearate to every 1000g of fine powde...

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Abstract

The invention discloses a medicine for abstinence treatment of alprazolam dependent anxiety insomnia, which is a clinically acceptable oral preparation prepared from active pharmaceutical ingredientsand pharmaceutically acceptable auxiliary materials, and the active pharmaceutical ingredients are prepared from the following traditional Chinese medicines in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of scutellaria baicalensis, 10-20 parts of Fructus Perillae, 4-8 parts of pericarpium zanthoxyli, 8-12 parts of cassia twig, 20-40 parts of spina date seed, 20-40 parts of raw oyster shell, 20-40 parts of gypsum, 10-20 parts of tuber fleeceflower stem, 10-20 parts of albizia flower, 20-40 parts of codonopsis pilosula, 4-8 parts of liquorice and 15-25 parts of jujube. The medicine provided by the invention can effectively relieve and improve the clinical signs and symptoms of alprazolam dependent anxiety insomnia, reduce the dosage of alprazolam, and effectively control andreduce the occurrence rate of alprazolam withdrawal syndrome.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, and relates to a medicine for withdrawal and treatment of alprazolam-dependent anxious insomnia, which uses traditional Chinese medicines as raw materials, and a preparation method of the medicine. Background technique [0002] Anxiety insomnia is a disease mainly characterized by difficulty in falling asleep, obvious anxiety state, often accompanied by palpitation, palpitation, emotional restlessness, irritability, irritability, nervousness, fear, restlessness and other clinical manifestations. The main manifestation is that it belongs to the category of "insomnia" and "depression disease" in traditional Chinese medicine. [0003] Most patients have difficulty falling asleep and frequent awakenings as the main symptoms, often accompanied by dreaminess, and fear after waking up from a dream. Patients are always worried that they will not be able to fall aslee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61P25/20A61P25/22A61K33/06A61K35/618
CPCA61K36/233A61K36/539A61K36/535A61K36/758A61K36/54A61K36/725A61K35/618A61K33/06A61K36/704A61K36/48A61K36/344A61K36/484A61P25/20A61P25/22A61K2236/331A61K2300/00
Inventor 赵雪杉杜秀娟
Owner 赵雪杉