Application of recombinant vibrio parahaemolyticus flagellin in improvement of fish immunity

Abstract

The invention discloses application of recombinant vibrio parahaemolyticus flagellin in improvement of fish immunity. It is found that the recombinant vibrio parahaemolyticus flagellin can induce expression of related immune genes and participate in activation of corresponding immune signal channels, the immunity of fishes is remarkably improved, the recombinant vibrio parahaemolyticus flagellin is expected to be developed into a natural fish immunopotentiator or immunologic adjuvant, and then fish diseases caused by vibrio parahaemolyticus are prevented or treated. Therefore, the recombinantvibrio parahaemolyticus flagellin has a good application prospect in improving fish immunity and preparing a fish immunopotentiator or immunologic adjuvant.

Description

technical field

[0001] The invention belongs to the technical field of genetic engineering. More specifically, it relates to the application of recombinant Vibrio parahaemolyticus flagellin in improving fish immunity. Background technique

[0002] Vibrio parahaemolyticus (Vibrio parahaemolyticus) is a Gram-negative, halophilic, mesophilic, rod-shaped bacterium commonly found in tropical and temperate oceans and naturally distributed in coastal habitats and estuarine areas around the world. Often isolated from a variety of seafood including cod, sardines, mackerel, flounder, clams, octopus, shrimp, crab, lobster, scallops and oysters. This bacterium is thought to be a major cause of gastroenteritis, wound infection and sepsis in humans. Consumption of raw or undercooked seafood, especially shellfish contaminated with Vibrio parahaemolyticus, may lead to the development of acute gastroenteritis characterized by diarrhea, headache, vomiting, nausea, abdominal cramps, and low-...

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