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Skeleton-doped degradable mesoporous silicon nanospheres with photo-thermal enhancement effect and synthesis method

An enhancement effect and doping-type technology, applied in the field of material chemistry, can solve the problems of biosafety of non-degradable nanomaterials, and achieve the effect of improving the effect of in vivo photothermal therapy, good water dispersibility, and strong photothermal effect

Inactive Publication Date: 2020-12-01
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The synthetic strategy of the present invention can also provide a new way for the construction of other small-sized nanomaterials, and at the same time solve the potential biosafety problems of large-sized non-degradable nanomaterials

Method used

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  • Skeleton-doped degradable mesoporous silicon nanospheres with photo-thermal enhancement effect and synthesis method
  • Skeleton-doped degradable mesoporous silicon nanospheres with photo-thermal enhancement effect and synthesis method
  • Skeleton-doped degradable mesoporous silicon nanospheres with photo-thermal enhancement effect and synthesis method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Stir the mixed aqueous solution of CTAB, triethylamine and carbon quantum dots at 50°C for 15 minutes. After the system is stable, add TBOS to the reaction system. After continuing the reaction at the same temperature for 6 hours, collect the precipitate and wash it. The obtained black powder After heating and stirring in an ethanol solution of ammonium nitrate, ultrasonically dispersing and centrifuging to remove residual impurities in the reaction, and then freeze-drying, the skeleton-doped degradable mesoporous silicon nanosphere with photothermal enhancement effect can be obtained.

Embodiment 2

[0032] Stir the mixed aqueous solution of CTAB, triethylamine and carbon quantum dots at 60°C for 15 minutes. After the system is stable, add TBOS to the reaction system. After continuing the reaction at the same temperature for 6 hours, collect the precipitate and wash it. The obtained black powder After heating and stirring in an ethanol solution of ammonium nitrate, ultrasonically dispersing and centrifuging to remove residual impurities in the reaction, and then freeze-drying, the skeleton-doped degradable mesoporous silicon nanosphere with photothermal enhancement effect can be obtained.

Embodiment 3

[0034]Stir the mixed aqueous solution of CTAB, triethylamine and carbon quantum dots at 70°C for 15 minutes. After the system is stable, add TBOS to the reaction system. After continuing the reaction at the same temperature for 6 hours, collect the precipitate and wash it. The obtained black powder After heating and stirring in an ethanol solution of ammonium nitrate, ultrasonically dispersing and centrifuging to remove residual impurities in the reaction, and then freeze-drying, the skeleton-doped degradable mesoporous silicon nanosphere with photothermal enhancement effect can be obtained.

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Abstract

The invention belongs to the field of material chemistry, and relates to skeleton-doped degradable mesoporous silicon nanospheres with a photo-thermal enhancement effect and a synthesis method thereof. According to the synthesis method, a cationic surfactant CTAB is used, reaction residual impurities are removed through a simple and convenient hydrogen bond / electrostatic assisted co-assembly strategy, and the skeleton-doped degradable mesoporous silicon nanospheres with the photo-thermal enhancement effect are obtained after drying. The skeleton-doped degradable mesoporous silicon nanosphereswith the photo-thermal enhancement effect are prepared. The mesoporous silicon nanospheres can effectively improve the photothermal effect and intratumoral accumulation and retention effect of carbonquantum dots, can be gradually degraded in vivo, are uniform in size, good in water dispersibility and high in biocompatibility, and can be widely applied to preparation of safe and efficient tumor photothermal therapy or combined therapy products.

Description

technical field [0001] The invention belongs to the technical field of material chemistry, and specifically relates to a skeleton-doped degradable mesoporous silicon nanosphere with a photothermal enhancement effect and a synthesis method thereof. Background technique [0002] The prior art discloses that the long-term accumulation toxicity in the body caused by non-degradability is a major bottleneck in the field of biomedical application of mesoporous silicon nanospheres. Studies have shown that, as a new type of nanoparticle, mesoporous silicon nanospheres are widely used in biosensing, in vivo imaging and drug delivery due to their adjustable mesoporous channels, easily functionalized surface and high specific surface area. Show great application prospects, but at the same time because of its non-degradable Si-O-Si framework, its biosafety in vivo application is widely questioned. Therefore, the preparation of biodegradable mesoporous silicon nanospheres is of great impo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/14A61K47/54A61P35/00
CPCA61K41/0052A61K9/145A61P35/00
Inventor 黄容琴钱敏
Owner FUDAN UNIV
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