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Method for synthesizing glycolide in one step

A technology of glycolide and glycolide, applied in chemical recovery, organic chemistry and other directions, can solve the problems of catalyst recovery and utilization with harsh glycolide synthesis conditions, and the unrecyclable use of catalysts.

Active Publication Date: 2020-12-01
CHINA CATALYST HLDG CO LTD
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  • Abstract
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Problems solved by technology

[0005] In view of the current development status of my country's coal chemical industry, we should make full use of the advantages of existing ethylene glycol technology and equipment capacity to develop low-cost methyl glycolate derivative products and applications. In recent years, it has been reported that methyl glycolate is used as a raw material to synthesize ethylene glycol lactide, but the synthesis method is still polycondensation-depolymerization method, and the catalyst is still not recyclable, which fails to fundamentally solve the problem of harsh synthesis conditions of glycolide and catalyst recycling

Method used

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  • Method for synthesizing glycolide in one step
  • Method for synthesizing glycolide in one step

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Experimental program
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Effect test

Embodiment 1

[0033] Sieve the tin-containing molecular sieve Sn-Beta (tin content: 1.7%, silicon-aluminum ratio: 3000) catalyst into 20-40 mesh particles, take 4g of catalyst and fill it into the middle section of the fixed-bed reaction tube, and fill the two ends of the reaction tube with inert quartz sand. The vaporization temperature of methyl glycolate was 220°C, the reaction temperature was 280°C, the feed rate of methyl glycolate was 8g / h, and the reaction was carried out under normal pressure. The reaction results are shown in Table 1.

Embodiment 2

[0035] Sieve the tin-containing molecular sieve Sn-Beta (tin content: 1.7%, silicon-aluminum ratio: 3000) catalyst into 20-40 mesh particles, take 4g of catalyst and fill it into the middle section of the fixed-bed reaction tube, and fill the two ends of the reaction tube with inert quartz sand. The vaporization temperature of methyl glycolate was 260°C, the reaction temperature was 280°C, the feed rate of methyl glycolate was 8g / h, and the reaction was carried out under normal pressure. The reaction results are shown in Table 1. The material obtained by the reaction is separated and purified to obtain the product glycolide, and the mass spectrograms of the product are shown in the attached figure 1 .

Embodiment 3

[0037] Sieve the tin-containing molecular sieve Sn-Beta (tin content: 1.7%, silicon-aluminum ratio: 3000) catalyst into 20-40 mesh particles, take 4g of catalyst and fill it into the middle section of the fixed-bed reaction tube, and fill the two ends of the reaction tube with inert quartz sand. The vaporization temperature of methyl glycolate was 260°C, the reaction temperature was 250°C, the feed rate of methyl glycolate was 8g / h, and the reaction was carried out under normal pressure. The reaction results are shown in Table 1.

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Abstract

The invention discloses a method for synthesizing glycolide in one step. Glycolide is used as a raw material, a tin-containing molecular sieve is used as a catalyst, the glycolide is synthesized by agas-phase one-step method, the conversion rate of glycolide in the reaction can reach 99% or above, and the selectivity of glycolide is greater than 90%. Compared with a traditional synthesis method of polycondensation first and then depolymerization, the method of the invention has the advantages of mild reaction conditions, high product yield, continuousness, and no involvement of high-vacuum and high-boiling-point solvents; compared with a conventional metal compound catalyst, the catalyst used in the method disclosed by the invention is safe, environment-friendly and recyclable; and the method is more suitable for industrial production of glycolide, and the synthesized glycolide can be used for preparing polyglycolic acid with the relative weight-average molecular weight of more than 100,000.

Description

technical field [0001] The invention relates to a method for synthesizing glycolide in one step, which belongs to the field of catalytic reaction. Background technique [0002] Environmental pollution (ie, "white pollution") caused by the uncontrolled mass production of non-degradable petroleum-based plastics and the abuse of disposable disposable petroleum-based plastic products has aroused serious concern worldwide. Biodegradable polymers based on renewable raw materials have achieved many important applications in the biomedical field, such as controlled release drug carriers, absorbable surgical sutures, implantable hard tissue repair materials, etc., and can be used as environmentally friendly materials for Manufacture of agricultural films, packaging materials, disposable sanitary products, disposable catering supplies, etc. [0003] Polyglycolic acid (PGA) is the simplest linear aliphatic polyester and the earliest commercially absorbable polymer material in vivo. D...

Claims

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Application Information

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IPC IPC(8): C07D319/12
CPCC07D319/12Y02P20/584
Inventor 李进孙红影王炳春王贤彬王岩
Owner CHINA CATALYST HLDG CO LTD
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