Synthesis method of 3', 5'-dichloro-2, 2, 2-trifluoroacetophenone
A technology of trifluoroacetophenone and synthesis method, which is applied in chemical instruments and methods, preparation of carbon-based compounds, preparation of organic compounds, etc., can solve the problems of extremely high requirements on industrial equipment, unsuitable for industrial production, and high industrial production costs , to achieve the effect of simplifying the production separation process, low price and reducing cost consumption
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Embodiment 1
[0039] A kind of synthetic method of 3',5'-dichloro-2,2,2-trifluoroacetophenone, using compound I as raw material, prepared through the following steps:
[0040] S1, react compound I with magnesium to obtain the Grignard reagent of compound I;
[0041] S2. React the Grignard reagent of compound I obtained in step S1 with compound II, and then treat with acid to obtain 3',5'-dichloro-2,2,2-trifluoroacetophenone.
[0042]In the above reaction, compound I is 1,3,5-trichlorobenzene, and compound II is trifluoroacetyldimethylamine.
[0043] Step S1 is specifically as follows:
[0044] S1-1. Weigh 7.2g of magnesium chips (0.3mol) into the reaction flask, add 60mL of tetrahydrofuran (solvent I), and stir evenly at room temperature to obtain the mixed system I;
[0045] S1-2. Weigh 34.4g of 1,3,5-trichlorobenzene and dissolve it with 90mL of tetrahydrofuran (solvent I) to obtain the mixed system II, and put the mixed system II in a separatory funnel for later use;
[0046] S1-3. Ra...
Embodiment 2
[0051] A method for synthesizing 3',5'-dichloro-2,2,2-trifluoroacetophenone, the difference from Example 1 is that in step S2, compound II uses the amount of trifluoroacetyl di Ethylamine (55.8 g) was substituted for trifluoroacetyldimethylamine.
Embodiment 3
[0053] A synthetic method of 3',5'-dichloro-2,2,2-trifluoroacetophenone, the difference from Example 1 is that in step S2, compound II uses trifluoroacetylpiper Pyridine (52.3 g) was substituted for trifluoroacetyldimethylamine.
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