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An antibacterial surface with "anti-fouling-sterilization-release" multifunctional response and its preparation method

A multi-functional and responsive technology, which can be used in biocide-containing paints, antifouling/underwater coatings, coatings, etc., to solve the problems that bacteria cannot be desorbed and dead bacteria cannot be removed, and achieves a simple and efficient preparation method. Long-lasting anti-bacterial adhesion and killing effect, expanding the application range

Active Publication Date: 2021-10-08
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention aims to provide a microgel with triple function response of "anti-fouling-sterilization-release", which can resist bacterial adhesion for a long time, and can kill and release dead bacteria even after adhesion. , to overcome the deficiencies in the prior art that the bacteria on the antibacterial surface cannot be desorbed and the dead bacteria cannot be removed

Method used

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  • An antibacterial surface with "anti-fouling-sterilization-release" multifunctional response and its preparation method
  • An antibacterial surface with "anti-fouling-sterilization-release" multifunctional response and its preparation method
  • An antibacterial surface with "anti-fouling-sterilization-release" multifunctional response and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Add 0.8g of N-isopropylacrylamide (NIPAM) into a 250mL round bottom flask, then add 0.2g of sulfobetaine methacrylate (SBMA), dissolve the drug completely with 100mL of deionized water, and continue to add 0.05g of N , N'-methylenebisacrylamide (MBAA), finally add 0.05g initiator potassium persulfate (KPS), pass N 2 30 min, and the whole process was carried out in an ice-water bath. However, after the passage, the temperature of the water bath was raised to 75°C and reacted for 5 hours to obtain a pure white turbid liquid, the product NIPAM / SBMA microgel, which was dialyzed in deionized water for 3 days to remove some small molecular impurities and obtain antifouling -Release the microgel spheres and observe their surface morphology with a scanning electron microscope (SEM), the results are as follows figure 2 As shown, the particles are uniform.

[0039] Tannic acid (TA) and Fe 3+ Collaborative assembly and microgel deposition on silicon wafers, first configure 20m...

Embodiment 2

[0041] Add 0.9g of N-isopropylacrylamide (NIPAM) into a 250mL round bottom flask, then add 0.1g of sulfobetaine methacrylate (SBMA), dissolve the drug completely with 100mL of deionized water, and continue to add 0.05g of N , N'-methylenebisacrylamide (MBAA), finally add 0.05g potassium persulfate (KPS), pass N 2 30 min, and the whole process was carried out in an ice-water bath. However, after the passage, the temperature of the water bath was raised to 75°C and reacted for 5 hours to obtain a pure white turbid liquid, the product NIPAM / SBMA microgel, which was dialyzed in deionized water for 3 days to remove some small molecular impurities and obtain antifouling - Releases microgel balls.

[0042] Tannic acid (TA) and Fe 3+ Collaborative assembly and microgel deposition on silicon wafers, first configure 20mL buffer solution containing 100mg microgel beads, 87.7mg NaCl, 340.2mg TA and 54mg Fe 3+ The solution was added to the silicon chip, the liquid level was not over th...

Embodiment 3

[0044] Add 0.7g of N-isopropylacrylamide (NIPAM) into a 250mL round bottom flask, then add 0.3g of sulfobetaine methacrylate (SBMA), dissolve the drug completely with 100mL of deionized water, and continue to add 0.05g of N , N'-methylenebisacrylamide (MBAA), finally add 0.05g potassium persulfate (KPS), pass N 2 30 min, and the whole process was carried out in an ice-water bath. However, after the passage, the temperature of the water bath was raised to 75°C and reacted for 5 hours to obtain a pure white turbid liquid, the product NIPAM / SBMA microgel, which was dialyzed in deionized water for 3 days to remove some small molecular impurities and obtain antifouling - Releases microgel balls.

[0045] Tannic acid (TA) and Fe 3+ Collaborative assembly and microgel deposition on silicon wafers, first configure 20mL buffer solution containing 100mg microgel beads, 87.7mg NaCl, 340.2mg TA and 54mg Fe 3+ The solution was added to the silicon chip, the liquid level was not over th...

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Abstract

The invention relates to the technical field of preparation of antibacterial surfaces, and discloses an antibacterial surface with multifunctional response of "anti-fouling-sterilization-release" and a preparation method thereof. The preparation method is as follows: (1) prepare antifouling-release microgel spheres by using responsive monomer and antifouling monomer; (2) combine antifouling-release microgel spheres with catechol polymers, Fe 3+ Co-precipitation of the solution to obtain the antibacterial surface with the multifunctional response of "anti-fouling-sterilization-release". The antibacterial surface can resist bacterial adhesion and kill bacteria for a long time, and when the amount of dead bacteria adhered reaches a certain level, changing the external conditions can release the bacteria adhered to the surface and realize functional regeneration.

Description

technical field [0001] The invention relates to the technical field of preparation of antibacterial surfaces, in particular to an antibacterial surface with multifunctional responses of "anti-fouling-sterilization-release" and a preparation method thereof. Background technique [0002] Microgel is a macromolecular network dissolved by a solvent. It is a cross-linked soft particle that can swell in a solvent and has a three-dimensional network structure. The general particle size is between 50 nanometers and several microns. They are unique systems, markedly different from common colloids such as rigid nanoparticles, flexible macromolecules, micelles or vesicles, in which microgel networks range in size from a few micrometers to nanometers (sometimes referred to as "nanogels"). glue"). In the collapsed state, they may resemble hard colloids, but can still contain large amounts of solvent; when swollen, they are soft, with a fuzzy surface, and dangling chains. Unlike linear ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D133/24C09D139/04C09D5/16C09D5/14C08F220/54C08F226/06C08F220/38C08F222/38C08F220/58
CPCC08F220/54C08F226/06C09D5/14C09D5/1662C09D5/1668C09D5/1687C09D133/24C09D139/04C08F220/387C08F222/385C08F220/58C08K5/1545
Inventor 杨晋涛毛世华何晓敏王晓宇钟明强陈枫范萍
Owner ZHEJIANG UNIV OF TECH