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Composite gel for treatment and evaluation of chronic wounds and preparation method of composite gel

A composite gel and chronic wound technology, applied in medical science, bandages, etc., can solve the problems of polyaniline compound application treatment and detection of chronic wounds, and achieve suitable for popularization and application, strong sterilizing activity, and biocompatibility high effect

Active Publication Date: 2020-12-11
杭州清大科瑞生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is no application of polyaniline compounds in the treatment and detection of chronic wounds

Method used

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  • Composite gel for treatment and evaluation of chronic wounds and preparation method of composite gel
  • Composite gel for treatment and evaluation of chronic wounds and preparation method of composite gel
  • Composite gel for treatment and evaluation of chronic wounds and preparation method of composite gel

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Effect test

Embodiment

[0035] 1. Preparation of materials:

[0036] (1) PSA preparation: Take 5.52 g of 1,3-propane sultone in a 50 mL round bottom flask, add 1.84 g of 4-aminobenzidine, N 2 React under ambient conditions for 3 hours. After the reaction, an appropriate amount of acetone was added to wash, and the solid product was obtained by filtration and vacuum-dried to evaporate the water. The solid was dissolved in water, filtered to obtain a blue liquid after ultrasonication, and freeze-dried to obtain the product PSA.

[0037] (2) Preparation of CA gel: Take 10 mg sodium alginate and add it to 1000 μL H 2 O, after fully dissolved, add 200 μL CaCl 2(5 mg / mL) solution, mixed evenly and stored in a refrigerator at 4 °C for 12 h to obtain a colorless and transparent CA gel.

[0038] (3) Preparation of CA@PSA gel: Add 10 mg sodium alginate to 1000 μL H 2 O, add 50 μ L PSA (3.5 mg / mL) solution after fully dissolving, 10 μ L HRP (2 mg / mL) solution, add 100 μ L CaCl after fully dissolving 2 (5 mg...

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Abstract

The present invention discloses a composite gel for treatment and evaluation of chronic wounds and a preparation method of the composite gel. 4-amino benzidine is selected as a raw material, and sulfonic groups are introduced into amino groups through 1, 3-propane sultone to generate 3-(4-phenylamino-phenylamino)-propane-1-sulfonic acid (PSA) to increase water solubility of p-phenylenediamine. Calcium alginate (CA) hydrogel with good biocompatibility is selected as a carrier, HRP and PSA are entrapped in the gel, and a transparent auxiliary material CA@PSA is prepared. The transparent auxiliary material CA@PSA is polymerized with aniline in the presence of H2O2 to form blue gel CA@NPSA. Therefore, wounds are subjected to a continuous treatment through PTT cooperating with CDT and wound healing is evaluated through color changes in an aniline polymerization process. The composite gel is high in biocompatibility, has a reference value in clinical medication for treatment and diagnosis ofwound infection caused by bacteria, and is suitable for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of composite gel, and in particular relates to a composite gel used for treating and evaluating chronic wounds and a preparation method thereof. Background technique [0002] Clinically, chronic wounds mostly refer to wounds formed by various reasons that have not healed after receiving treatment for more than one month, and have no tendency to heal. The etiology of chronic wounds is complex. The traditional view of chronic wound treatment is that wound healing requires a dry environment and the participation of atmospheric oxygen. Therefore, only dry and breathable dressings such as gauze and cotton pads can protect the wound and promote wound healing. It is traditional dry healing. However, this traditional dressing has limited absorbency, which tends to create a dry environment for the wound, which dehydrates the wound cells and causes scabs. The adverse effect of scab is that it obviously hinders the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0028A61L26/0061A61L26/0066A61L26/008A61L2300/254A61L2300/404A61L2300/442C08L5/04
Inventor 蒋邦平沈星灿王瑷辉李红燕
Owner 杭州清大科瑞生物科技有限公司
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