49 results about "O-aminobiphenyl" patented technology

4-aminobiphenyl derivative arylamine compounds are formed by providing an iodinated organic compound; substituting the iodinated organic compound at carboxylic acid groups thereof to provide ester protecting groups; conducting an Ullman condensation reaction to convert the product of step (ii) into an arylamine compound; and conducting a Suzuki coupling reaction to add an additional phenyl group to the arylamine compound in the 4-position relative to the nitrogen.

The invention relates to an o-aminobiphenyl compound synthesis method, which comprises: carrying out a reaction on an o-nitroaromatic formic acid compound, an alkali and a solvent, removing water, adding substituted halobenzene, a catalyst and a ligand, carrying out a reaction, or carrying out a reaction on a pre-prepared o-nitroaromatic formate, substituted halobenzene, a catalyst, a ligand and a solvent, and carrying out post-treatment to obtain the o-aminobiphenyl compound. According to the present invention, the o-aminobiphenyl compound is synthesized by using the easily available or easily prepared o-nitroaromatic formate and the substituted halobenzene as the raw material through the one-step method without the use of hydrogen and other hazardous reducing agents, such that the coupling and nitro reduction continuous reaction is achieved, and the advantages of new reaction, safety, high efficiency, simple operation and low cost are provided.

The invention discloses a method for determining six aromatic amine compounds in cigarette mainstream smoke by using online SPE / LC-MS / MS. It uses the Cambridge filter and an absorption bottle containing 2% formic acid solution to capture the aromatic amine compounds in the main cigarette smoke particle and gas phase matters, respectively, ultrasonically extracting the filter by 2% formic acid solution, adding interior labels into the two solutions and determining the six aromatic amine compounds by online SPE / LC-MS / MS, including o-toluidine, 2,6-dimethylaniline, o-anisidine, 1-aminonaphthalene, 2-aminonaphthalene and 4-aminobiphenyl. The method has the advantages of simplifying the sample pretreatment process and extracting with the formic acid solution to reduce the pollution. The two-dimensional in-line solid-phase extraction composed of the cationic column and the reversed-phase C18 column is used to purify the sample to be tested and the purification effect is good; each target is quantitatively analyzed using their specific internal standard, effectively reducing the matrix effect.

The invention relates to a novel enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a gamma-amino-delta-biphenyl-alpha-methylalkanoic acid, or acid ester, backbone.

A method for detecting 10 types of aromatic amines compounds (including aniline, ortho toluidine, m-toluidine, p-aminotoluene, m-phenylenediamine, m-methoxyaniline, 1- naphthylamine, 2- naphthylamine, 3- aminobphenyl and 4- aminobphenyl) in cigarette mainstream smoke by liquid chromatography-tandem mass spectrometry is characterized in that a Cambridge filter and an absorbing bottle containing 5% of HC1 solution respectively gather the aromatic amines compounds in a particle phase matter and a gas phase matter of mainstream smoke, after the 5%HCI solution is used for extracting the aromatic amines compounds on the filter, the aromatic amines compounds are purified by an HLB (hydrophile-lipophile balance) solid-phase extraction column, and a liquid chromatography-tandem mass spectrometry instrument is used for determining the 10 types of aromatic amines in the mainstream smoke in cigarettes. Compared with an existing GC-MS (gas chromatography-mass spectrometer) analysis method for detecting aromatic amines in mainstream smoke of cigarettes, the method does not need derivatization reaction or liquid-liquid extraction operation, greatly simplifies pretreatment steps of samples, improves analysis efficiency, and can more comprehensively detect harmful aromatic amines compounds in mainstream smoke of cigarettes.

The invention relates to a phenylboronic acid polymer based on amino epoxy ring-opening polymerization as well as a preparation method and application thereof. The mass composition of raw materials ofthe phenylboronic acid polymer is 0.5-2.1% of m-amino-phenylboronic acid, 5.1-18.5% of tri(4-hydroxyphenyl)methane triglycidyl ether (or tri(4-hydroxyphenyl)methane triglycidyl ether), 0.9-3.9% of hexamethylene diamine (or 4,4'-diaminodicyclohexylmethane, or 4,4'-diaminobiphenyl), 0-2.0% of amino magnetic spheres (or other aminated solid matrix materials), 15-35% of dimethyl sulfoxide, and 45-78.5% of polyethylene glycol 200. The phenylboronic acid polymer provided by the invention is simple in preparation method, and has specific adsorption capability on hydrophobic nitrogen-containing compounds, high adsorption capacity, and wide application prospect.

The invention relates to a novel heat-resistant rubber part. The novel heat-resistant rubber part is characterized by comprising the following components in parts: 100-120 parts of No.1 natural rubber, 2-4 parts of accelerant TT, i.e. tetramethyl thiuram disulfide, 4-6 parts of zinc oxide, 1-2 parts of antiager 4010, i.e. N-benzyl-N'-cyclohexyl p-phenylenediamine, 1-3 parts of stearic acid, 7-9 parts of pitch, 15-25 parts of spraying carbon black, 50-60 parts of calcium carbonate, 2.7 parts of antiager BLE (the Chinese name is an acetone and diphenylamine high-temperature condensation compound 4-aminobiphenyl, and the molecular formula is C15H15N), 31 parts of barium sulfate and 3-5 parts of ortho-dibutyl ester. The novel heat-resistant rubber part has the advantages that the heat ageing performance of the rubber part is increased by increasing a heat-proof aging assistant in rubber, and the service life is prolonged.

A process for preparing a tetra-substituted aminobiphenol macrocyclic ligand having the structure (I), comprising the step of treating a precursor compound having the structure (II) with a compound having the structure R6-L where L represents a leaving group (hereinafter compound (III)) in the presence of a base.

The invention discloses a method for determining six aromatic amine compounds in cigarette mainstream smoke by using online SPE / LC-MS / MS. It uses the Cambridge filter and an absorption bottle containing 2% formic acid solution to capture the aromatic amine compounds in the main cigarette smoke particle and gas phase matters, respectively, ultrasonically extracting the filter by 2% formic acid solution, adding interior labels into the two solutions and determining the six aromatic amine compounds by online SPE / LC-MS / MS, including o-toluidine, 2,6-dimethylaniline, o-anisidine, 1-aminonaphthalene, 2-aminonaphthalene and 4-aminobiphenyl. The method has the advantages of simplifying the sample pretreatment process and extracting with the formic acid solution to reduce the pollution. The two-dimensional in-line solid-phase extraction composed of the cationic column and the reversed-phase C18 column is used to purify the sample to be tested and the purification effect is good; each target is quantitatively analyzed using their specific internal standard, effectively reducing the matrix effect.

The invention provides a preparation method of an organic covalent framework material with a large aperture. Adopt solvothermal method to prepare cuprous chloride catalyst with nanometer scale, select 1,3,5-three [4-amino (1,1-biphenyl-4-yl)] benzene and benzidine as monomer molecule, in Preparation of Organic Polymers by Amino Coupling Reaction Catalyzed by Cuprous Chloride Nanocrystals. The method disclosed in the invention can be carried out at room temperature, the reaction conditions are mild, and it has the characteristics of simple preparation, low cost, and easy industrial batch production, and the prepared polymer has large pore size, high chemical stability and thermal stability , can be used in composite electrode materials, organic dyes, biomedicine and many other fields.

The invention discloses a preparation method of 2,2'-bis(trifluoromethyl)-4,4'-biphenyl dicarboxylic acid chloride, which comprises the following steps: a. taking 2,2'-bis(trifluoromethyl) base)-4,4'-diaminobiphenyl as the starting material, firstly through the diazotization reaction, and then through the bromination reaction to obtain 2,2'-bis(trifluoromethyl)-4,4'-dibromide Biphenyl; b, 2,2'-bis(trifluoromethyl)-4,4'-dibromobiphenyl undergoes a Grignard reaction / substitution reaction followed by reaction with carbon dioxide to give 2,2'-bis(trifluoromethyl) base)-4,4'-biphenyldicarboxylic acid; c, 2,2'-bis(trifluoromethyl)-4,4'-biphenyldicarboxylic acid was chlorinated to obtain 2,2'-bis(trifluoromethyl) Fluoromethyl)-4,4'-biphenyl dicarboxylic acid chloride. The method of the invention has short synthesis route, low production cost, especially high reaction yield, no need of highly toxic substances, high safety, and is suitable for large-scale industrial production.

The invention relates to a preparation method of 3,3',4,4'-tetraaminobiphenyl, comprising the following steps: (1) using o-chloronitrobenzene compounds, alkalis and aldehyde compounds as raw materials, In the solvent, 1,4-naphthoquinone compounds are used as catalysts for condensation reaction; (2) 1,4-naphthoquinone compounds and aluminum-nickel alloys are added to the condensate as reduction catalysts, sodium dodecylbenzenesulfonate The compound is used as an emulsifier, reacted with hydrazine hydrate to obtain a hydrogenation reaction solution, then cooled to crystallize and recrystallized, cooled to filter or concentrate to obtain a hydrogenated product; (3) the hydrogenated product was subjected to a rearrangement reaction under acidic conditions to obtain a rearrangement Product; (4) The rearrangement product uses a copper salt compound as a catalyst, reacts with ammonia water and ammonia gas under high temperature and high pressure, and cools and filters to obtain 3,3',4,4'-tetraaminobiphenyl. The invention reduces environmental pollution while improving product quality, makes product production clean and environmentally friendly, and makes the product more suitable for mass production.

The invention discloses a synthetic method of a ratio pH sensor based on a ternary covalent organic framework material.According to the method, the covalent organic framework material is constructed through a ternary doping strategy of 2-hydroxybenzene-1, 3, 5-tricarboxaldehyde, 5, 5 '-diamino-2, 2'-dipyridyl and 4, 4 '-diamino-3, 3'-biphenyl dicarboxylic acid, and the ratio pH sensor based on the ternary covalent organic framework material is obtained. The fluorescent probe has a ratio response to pH in a range of 2-5.5. And the blank that no multi-covalent organic framework ratio pH sensor exists before is filled. The method disclosed by the invention is low in equipment requirement and simple in preparation method. And the prepared ternary covalent organic framework material has relatively high chemical stability and relatively high application value in the aspect of fluorescence detection. The invention also discloses an application of the ternary covalent organic framework material in ratio pH sensing.

The invention discloses a preparation method and application of a fluorescent covalent organic framework connected by imine bonds, and belongs to the technical field of environmental protection. Reaction of 1,3,6,8-tetrakis(4-formylphenyl)pyrene and 4,4'-diamino-[1,1'-biphenyl]-3,3'-diol via Schiff base Synthesis of imine-linked fluorescent covalent organic frameworks. The fluorescent covalent organic framework uses imine bonds as connecting units, surrounded by a large number of hydroxyl functional groups, which can selectively bind uranyl ions. Meanwhile, based on the excellent fluorescence properties of pyrene-based units, a rapid and sensitive detection method for uranyl ions was established. In addition, the phenolic hydroxyl groups in the imine-bonded fluorescent covalent organic framework can also reduce soluble U(VI) to insoluble U(IV), which greatly improves the adsorption capacity for uranyl ions. The method of the invention has the advantages of simple method, stable structure and environmental friendliness for preparing the imine bond-linked fluorescent covalent organic framework, which can be used for highly sensitive detection and selective recovery of uranyl ions, and has good application prospects.

The invention belongs to the field of nano materials and biosensing, and particularly relates to preparation and application of a nucleic acid functionalized MOF (Metal Organic Framework) material. According to the method, 2-amino-4, 4 '-biphenyl dicarboxylic acid and ZrCl4 are subjected to a hydrothermal reaction to generate UiO-67-NH2, single-stranded DNA with carboxyl is connected to the surface of the UiO-67-NH2 through an amidation reaction, an aptamer chain and the single-stranded DNA are partially hybridized, fluorescent dye is wrapped in MOF, a nucleic acid functionalized MOF material is formed, and it is found that the prepared nucleic acid functionalized MOF has excellent stimuli-responsive release performance. The nucleic acid functionalized MOF prepared by the invention has good stability and biocompatibility, and has a wide application prospect in the aspects of drug delivery and biosensing.