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Application of composition to preparation of medicine for treating or preventing chronic sinusitis and nasal polyp

A technology for chronic sinusitis and a composition, applied in the application field of traditional Chinese medicine, can solve problems such as recurrent pain, and achieve the effects of improving the disorder of arrangement of epithelial cells in the sinuses and nasal cavity mucosa, reducing the hyperplasia of the lower mucosa, and improving the sense of smell.

Inactive Publication Date: 2020-12-18
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although long-term use of intranasal corticosteroids and functional endoscopic sinus surgery can significantly improve the cure rate of chronic sinusitis and nasal polyps, about 10% of patients still experience recurrent pain after surgery

Method used

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  • Application of composition to preparation of medicine for treating or preventing chronic sinusitis and nasal polyp
  • Application of composition to preparation of medicine for treating or preventing chronic sinusitis and nasal polyp
  • Application of composition to preparation of medicine for treating or preventing chronic sinusitis and nasal polyp

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 Chinese medicine composition granule

[0040] The traditional Chinese medicine composition of this example is prepared from the following raw materials: Magnolia magnolia 300g, Su Ye 300g, Nepeta 250g, Angelica dahurica 250g, Arctium 250g, Xanthium 250g, Schisandra 250g, Pseudostellaria 300g and raw licorice 150g.

[0041] The Chinese medicine composition is prepared according to the following method:

[0042] (1) According to the selected parts by weight, mix the magnolia, perilla, nepeta, and cocklebur, add 12 times the weight of the medicine, soak for 2 hours, distill for 5 hours, extract volatile oil, add β-cyclodextrin Prepare volatile oil clathrate and set aside; continue to decoct the remaining residue for 1 hour, filter and combine the resulting decoction and concentrate to a thick paste I with a relative density of 1.30;

[0043] (2) Mix the said Radix Pseudostellariae and Radix Glycyrrhizae according to the selected parts by we...

Embodiment 2

[0046] The preparation of embodiment 2 Chinese medicine composition tablet

[0047] The Chinese medicine composition that is used for the treatment of chronic sinusitis, nasal polyps of the present embodiment, its formula is as follows:

[0048] Magnolia 150g, Su Ye 550g, Nepeta 200g, Angelica dahurica 400g, Burdock 200g, Xanthium 400g, Schisandra 200g, Pseudostellaria 500g and raw licorice 200g.

[0049] The Chinese medicine composition is prepared according to the following method:

[0050] (1) According to the selected parts by weight, take the magnolia, perilla leaves, nepeta, and cocklebur seeds, mix them, add water 11 times the weight of the medicine, soak for 1.5 hours, distill for 6 hours, extract volatile oil, and add β-cyclodextrin Prepare volatile oil clathrate, set aside, continue to decoct the remaining residue for 0.8 hours, filter and combine the obtained decoction and concentrate to a thick paste I with a relative density of 1.20;

[0051] (2) Mix the said Ra...

Embodiment 3

[0054] The curative effect of embodiment 3 Chinese medicine compositions to experimental chronic sinusitis mice

[0055] 1 Experimental materials

[0056] 1.1 Reagents and Reagents

[0057] Composition granules prepared in Example 1 (2.3g crude drug / g); ATCC 49619 Streptococcus pneumoniae strain, Shanghai Chuanxiang Biology; IL-33, IL-17, IL-13 detection kits, all purchased from Nanjing Jiancheng Institute of Bioengineering.

[0058] 1.2 Instruments and equipment

[0059] New Classic MF MS1003S / 01 electronic balance: Mettler Toledo, Switzerland; 5804R low-temperature high-speed centrifuge: Eppendorf, Germany; Flexstation 3 multifunctional microplate reader: MD, USA.

[0060] 1.3 Experimental animals

[0061] Healthy C57BL / 6J mice, SPF grade, 6-8 weeks old, weighing 18-22g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., production license number: SCXK (Beijing) 2019-0010.

[0062] 2 Experimental methods

[0063] 2.1 Preparation of expe...

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Abstract

The invention provides an application of a composition to preparation of a medicine for treating or preventing chronic sinusitis and nasal polyp. The composition is prepared from the following components in parts by weight of 1-6 parts of magnolia biondii flower buds, 1-6 parts of perilla frutescens leaves / twigs, 1-5 parts of schizonepeta tenuifolia above-ground parts, 1-5 parts of radix angelicaedahurica, 1-5 parts of arctium lappa fruits, 1-5 parts of xanthium sibiricum fruits, 1-5 parts of fructus schisandra chinensis, 1-6 parts of radix pseudostellaria heterophylla and 1-3 parts of unprocessed glycyrrhiza uralensis roots. The composition provided by the invention can improve the condition of paranasal sinus and nasal mucosa epithelial cell arrangement disorder of experimental chronicsinusitis mice, alleviate submucosal hyperplasia and reduce the contents of IL-33, IL-17 and IL-13 in nasal cavity lavage fluid. In addition, the olfactory disorder of experimental nasal polyp mice can be improved, mucosal hyperplasia can be relieved, the number of nasal polyps can be reduced, and the contents of IL-6, TNF-alpha, IFN-gamma and IL-23 in nasal cavity lavage fluid of the mice can bereduced, so that the composition has a good effect of improving chronic sinusitis and nasal polyps.

Description

technical field [0001] The invention belongs to the field of application of traditional Chinese medicines, and relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in the preparation of medicines for treating or preventing chronic sinusitis and nasal polyps. Background technique [0002] Chronic sinusitis and nasal polyps are common and frequently-occurring diseases in otolaryngology. Sinusitis occurs in the nasal cavity and sinus mucosa, and is divided into acute sinusitis and chronic sinusitis according to the occurrence and duration of symptoms and signs. Chronic rhinosinusitis (CRS) was classified according to the middle meatus with or without nasal polyps (NP): CRS without nasal polyps (CRSs NP) and CRS with nasal polyps (CRSw NP). Nasal polyps (Nasal polyps, NP) are litchi flesh-like neoplasms protruding from the mucosal surface in the nasal cavity or sinuses. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61K36/79A61K47/69A61P11/02
CPCA61K36/232A61K36/28A61K36/36A61K36/484A61K36/535A61K36/538A61K36/57A61K36/575A61K36/79A61K2236/331A61K2236/333A61K47/6951A61P11/02A61K2300/00
Inventor 肖伟贾银芝李贵平罗勇王永香张书嘉王鑫胡晗绯章晨峰王振中
Owner JIANGSU KANION PHARMA CO LTD
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