Blank multivesicular liposome as well as preparation method and device thereof

A multivesicular liposome and blank technology, which is applied in the fields of botanical equipment and methods, chemical instruments and methods, animal repellents, etc., can solve the problem of loose multivesicular liposome structure, uneven vesicle size, Poor vesicle stability and other problems, to achieve the effect of improving drug release time, good vesicle stability, and compact structure
CN112120022AInactive Publication Date: 2020-12-25YANGZHOU SPED CHEM
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
YANGZHOU SPED CHEM
Publication Date
2020-12-25
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses a blank multivesicular liposome and a preparation method and device thereof, and belongs to the field of pesticide adjuvants. The preparation raw materials of the polycystic lipidosome provided by the invention comprise phospholipid substances, sterol substances, neutral lipidosome, fatty acid ester substances and vitamins; the polycystic lipidosome containing vesicles withhigh electronegativity and steric hindrance can be obtained; coagulation of the multivesicular liposome can be effectively inhibited, the drug release time is prolonged, and the drug effect is improved. The invention provides a blank multivesicular liposome preparation method and device. According to the blank multivesicular liposome preparation method and device, a continuous flow micro-channelreactor is used for replacing traditional high-speed shearing equipment; by means of the device, the vesicle stability and particle size uniformity of the multivesicular liposome can be obviously improved, the vesicle size is reduced, the environment-friendly multivesicular liposome can wrap pesticide active matters and is applied to the field of pesticides.
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Description

Technical field

[0001] The invention belongs to the field of pesticide additives, and more specifically, relates to a blank multivesicular liposome and a preparation method and device thereof.Background technique

[0002] Multivesicular liposomes (MVL) are composed of multiple non-concentric aqueous drug solution vesicles, which are separated by a continuous non-concentric lipid bilayer, and have a high encapsulation rate for water-soluble drugs. In particular, multivesicular liposomes release drugs through ruptured vesicles, while intact vesicles remain intact. The non-concentric topological structure of multivesicular liposomes makes it form a "reservoir" at the injection site. With the continuous degradation of the lipid bilayer, the drug encapsulated in it is gradually released, resulting in a good relief. The drug release effect is avoided while avoiding the sudden release effect, and the effect of controlling the drug release time from a few days to several weeks can be obtained by ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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