Blank multivesicular liposome as well as preparation method and device thereof

Abstract

The invention discloses a blank multivesicular liposome and a preparation method and device thereof, and belongs to the field of pesticide adjuvants. The preparation raw materials of the polycystic lipidosome provided by the invention comprise phospholipid substances, sterol substances, neutral lipidosome, fatty acid ester substances and vitamins; the polycystic lipidosome containing vesicles withhigh electronegativity and steric hindrance can be obtained; coagulation of the multivesicular liposome can be effectively inhibited, the drug release time is prolonged, and the drug effect is improved. The invention provides a blank multivesicular liposome preparation method and device. According to the blank multivesicular liposome preparation method and device, a continuous flow micro-channelreactor is used for replacing traditional high-speed shearing equipment; by means of the device, the vesicle stability and particle size uniformity of the multivesicular liposome can be obviously improved, the vesicle size is reduced, the environment-friendly multivesicular liposome can wrap pesticide active matters and is applied to the field of pesticides.

Description

Technical field[0001]The invention belongs to the field of pesticide additives, and more specifically, relates to a blank multivesicular liposome and a preparation method and device thereof.Background technique[0002]Multivesicular liposomes (MVL) are composed of multiple non-concentric aqueous drug solution vesicles, which are separated by a continuous non-concentric lipid bilayer, and have a high encapsulation rate for water-soluble drugs. In particular, multivesicular liposomes release drugs through ruptured vesicles, while intact vesicles remain intact. The non-concentric topological structure of multivesicular liposomes makes it form a "reservoir" at the injection site. With the continuous degradation of the lipid bilayer, the drug encapsulated in it is gradually released, resulting in a good relief. The drug release effect is avoided while avoiding the sudden release effect, and the effect of controlling the drug release time from a few days to several weeks can be obtained by ...

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Problems solved by technology

[0007] Aiming at many problems such as the loose structure of the multivesicular liposome obtained by the existing preparation method, poor vesicle stability, excessively large and uneven particle size, etc., the present invention provides a preparation method of a blank multivesicular liposome, which utilizes continuous An environment-friendly multivesicular liposome with good vesicle stability and uniform particle size distribution was obtained by flow microchannel reactor;

[0008] In view of the traditional high-speed shearing equipment used in the preparation process of existing multivesicular liposomes, resulting in problems such as loose multivesicular liposome structure, leakage, excessive particle size and uneven particle size, the present invention provides a blank multi-vesicle liposome The preparation device of vesicular liposomes uses a continuous flow microchannel reactor to replace traditional high-speed shear equipment to improve the vesicle stability and particle size uniformity of multivesicular liposomes and reduce the vesicle size;

[0009] In view of the problems that the existing multivesicular liposome vesicles are not uniform in size, need to be processed again before use, and the size of the vesicles is too large to penetrate the target waxy layer, pores, etc., which are not suitable for the field of pesticide preparations. The invention provides an environment-friendly multivesicular liposome with good vesicle stability, uniform and moderate particle size distribution, and capable of encapsulating pesticide active substances for use in the field of pesticides

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