A kind of hydrogel material and its preparation method and application

A hydrogel and collagen technology, applied in prosthetics, tissue regeneration, medical science, etc., can solve the problems of cross-linking relying on toxic chemical cross-linking agents, difficulty in meeting the needs of use, insufficient mechanical properties, etc., and achieve excellent mechanical properties and biological activity, three-dimensional structure is not limited, and the effect of a wide range of applications

Active Publication Date: 2022-04-08
SUN YAT SEN UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

However, there are two problems in the use of collagen at present. One is that the cross-linking mostly relies on toxic or expensive chemical cross-linking agents; the other is that the single-component collagen system has insufficient mechanical properties after cross-linking, and it is difficult to meet different application requirements.

Method used

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  • A kind of hydrogel material and its preparation method and application
  • A kind of hydrogel material and its preparation method and application
  • A kind of hydrogel material and its preparation method and application

Examples

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preparation example Construction

[0030] The invention provides a method for preparing a hydrogel material, the schematic diagram of which is as follows: figure 1 shown, including:

[0031] (1) Preparation of type II collagen modified by acrylic anhydride

[0032] Using type II collagen extracted from porcine articular cartilage as raw material, the extracted type II collagen was subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to characterize its purity and molecular weight. The obtained results are as follows: figure 2 shown.

[0033] Depend on figure 2 It can be seen that the obtained type II collagen has β chain and γ chain, only one α chain, and there is no staining band below 100 kDa, which conforms to the characteristics of type II collagen, and the isolated type II collagen has a high purity.

[0034] The specific method for modifying type II collagen with acrylic anhydride comprises the following steps:

[0035] S1. Dissolving 0.25g type II collagen (Collagen) in...

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Abstract

The invention discloses a hydrogel material and its preparation method and application. The preparation raw materials of the hydrogel material include acrylic anhydride modified collagen, polyethylene glycol diacrylate, photoinitiator and solvent. Among them, the combination of acrylic anhydride-modified collagen and polyethylene glycol diacrylate can achieve complementary performance; specifically, by adding acrylic anhydride-modified collagen to polyethylene glycol diacrylate, the hydrogel material can be endowed with Biological activity, and the existence of polyethylene glycol diacrylate can solve the defect of insufficient mechanical properties of collagen when used alone; and by using acrylic anhydride to modify collagen, it can solve the problem that collagen cross-linking relies more on toxic or expensive chemical cross-linking agents Disadvantages: The modified collagen can be cross-linked and cured by ultraviolet light, the molding process is simple, the three-dimensional structure is not limited, and the application range is wide. Through the above methods, the hydrogel material of the present invention has excellent mechanical properties and biological activity.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a hydrogel material and its preparation method and application. Background technique [0002] As a fast-growing interdisciplinary subject, biomaterials science has put forward an urgent need for the properties and manufacturing methods of various biomaterials. Tissue engineering requires biomaterials with sufficient and appropriate mechanical properties for various applications such as hard and soft tissue replacement. At the same time, biomaterials should also have good biocompatibility. Compared with physical crosslinking, chemical crosslinking can produce sufficient structural stability to meet various properties required for biomedical applications, among which photocrosslinking has been widely used due to its many advantages. [0003] Natural biomaterials have been widely used in the field of tissue engineering due to their abundant sources, excellent biocompatibility...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F299/00C08F299/02C08J3/075C08L55/00A61L27/52A61L27/50A61L27/60A61L27/24A61L27/18
CPCC08F299/00C08F299/028C08J3/075A61L27/52A61L27/50A61L27/60A61L27/24A61L27/18C08J2355/00A61L2430/02A61L2430/06A61L2430/32C08L71/02
Inventor 王山峰张阳全大萍
Owner SUN YAT SEN UNIV
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