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Gliquidone dropping pill and preparation method thereof

A technology of glipaquinone and dripping pills, applied in the field of pharmaceutical processing, can solve the problems of increasing insulin sensitivity and utilization of sugar, and achieve the effect of improving the qualified rate of products

Pending Publication Date: 2021-01-05
CHENGDU HENGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] May also increase extrapancreatic tissue sensitivity to insulin and glucose utilization (probably primarily through post-receptor effects)
[0006] There are tablets, capsules and dispersible tablets on the market for gliquidone preparations, but there is no drop pills on the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A gliquidone dropping pill is composed of the following components: active agent, disintegrating agent, pill-forming matrix, coating powder;

[0026] Wherein the active agent is gliquidone, the disintegrant is polycross-linked carboxymethylcellulose sodium, the pill-forming matrix includes poloxamer, and the coating powder is gastric-soluble film coating powder. Gliquidone, polycroscarmellose sodium, and poloxamer are calculated at a weight ratio of 30:20:40, and stomach-soluble film-coating powder and gliquidone are calculated at a weight ratio of 3.5:50 .

[0027] Specifically, in each drop pill, there is 30 mg of gliquidone, 20 mg of polycroscarmellose sodium, 40 mg of poloxamer, and 2.1 mg of gastric-soluble film-coating powder.

Embodiment 2

[0029] A gliquidone dropping pill is composed of the following components: active agent, disintegrating agent, pill-forming matrix, coating powder;

[0030] Wherein the active agent is gliquidone, the disintegrant is polycross-linked carboxymethylcellulose sodium, the pill-forming matrix includes poloxamer, and the coating powder is gastric-soluble film coating powder. Gliquidone, polycroscarmellose sodium, and poloxamer are calculated at a weight ratio of 30:20:40, and stomach-soluble film-coating powder and gliquidone are calculated at a weight ratio of 3.5:50 .

[0031] Specifically, in each drop pill, there is 60 mg of gliquidone, 40 mg of polycroscarmellose sodium, 80 mg of poloxamer, and 4.2 mg of gastric-soluble film-coating powder.

Embodiment 3

[0033] A preparation method for gliquidone dropping pills, comprising the following steps:

[0034] Each component is weighed according to the following component weight ratio:

[0035] 45 mg of gliquidone, 30 mg of polycroscarmellose sodium, 60 mg of poloxamer, and 3.15 mg of gastric-soluble film-coating powder;

[0036] Stir and mix the poloxamer, then slowly heat to a molten state at 55°C;

[0037] Further, add the molten material in step S1 to the DWJ-AS drip irrigation equipment, the diameter of the equipment is 1.3mm~1.1mm, the dripping speed is 50 drops / min~60 drops / min, and the temperature in the drip irrigation equipment is kept at 75°C. After the poloxamer is liquefied, add gliquidone and mix thoroughly for 1 hour;

[0038] Further, dripping, the speed of dripping is adjusted by controlling the pressure in the drip irrigation equipment. The medicinal liquid dripped from the drip irrigation equipment is initially cooled by the cooling air made by the refrigerator. D...

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Abstract

The invention relates to the field of medicine processing, and discloses a gliquidone dropping pill and a preparation method thereof. The preparation method of the gliquidone dropping pill comprises the steps that S1, poloxamer and poly-croscarmellose sodium are mixed and slowly heated to be in a molten state; S2, a melt obtained in the step S1 is added into drip irrigation equipment, heating is carried out to liquefy the melt, then gliquidone is added, and full mixing is carried out; S3, dropwise adding is added, specifically, the dropwise adding speed is adjusted by controlling the pressurein the drip irrigation equipment, liquid medicines dropped from the drip irrigation equipment are primarily cooled by cooling gas, then the liquid medicines are dropped into dimethicone cooling liquidfor secondary cooling, dimethicone is drained off, cleaning is carried out by using petroleum ether, and volatilizing is carried out to form a primary dropping pill; and S4, coating is carried out, specifically, the preliminary dropping pill is coated to form a dropping pill finished product. The invention also discloses a gliquidone dropping pill component. The gliquidone dropping pill has the beneficial effects that the gliquidone is prepared into the dropping pill, so that disintegration is easy, and drug absorption is facilitated; and multiple cooling technologies are adopted for the dropped liquid medicines, and the product percent of pass is increased.

Description

technical field [0001] The invention relates to the field of pharmaceutical processing, in particular to a sulfonylurea anti-type 2 diabetes drug preparation and a preparation method thereof, in particular to a gliquidone dropping pill and a preparation method thereof. Background technique [0002] The main pharmacological effects of gliquidone are as follows: [0003] To promote the secretion of insulin by pancreatic islet B cells, the prerequisite is that the pancreatic islet B cells have certain functions of synthesizing and secreting insulin; [0004] By increasing portal vein insulin levels or acting directly on the liver, inhibiting hepatic glycogenolysis and gluconeogenesis, reducing hepatic production and output of glucose; [0005] May also increase extrapancreatic tissue sensitivity to insulin and glucose utilization (probably primarily through post-receptor effects). [0006] There are tablets, capsules and dispersible tablets on the market for gliquidone prepar...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K47/38A61K47/10A61K31/64A61P3/10A61P5/50
CPCA61K9/2031A61K9/2054A61K9/28A61K31/64A61P3/10A61P5/50
Inventor 刘辉陆泽润肖波石峰文颖
Owner CHENGDU HENGRUI PHARMA
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