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Paging ligament regeneration enhancing stent and preparation method thereof

A paging and ligament technology, applied in ligament, medical science, muscle and other directions, can solve the problems of inability to induce effective tissue regeneration, lack of application, etc., to enhance cell migration and adhesion and angiogenesis, improve clinical efficacy, and promote ligament tissue regeneration. Effect

Pending Publication Date: 2021-01-29
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is mainly used in bone tissue reconstruction and repair, but it is lack of application in soft tissue repair such as tendon and ligament regeneration.
Moreover, at present, for the repair of ligaments and tendons, non-degradable biomaterials are mainly used for mechanical support, which cannot induce effective tissue regeneration.

Method used

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  • Paging ligament regeneration enhancing stent and preparation method thereof
  • Paging ligament regeneration enhancing stent and preparation method thereof
  • Paging ligament regeneration enhancing stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This embodiment provides a paginated ligament regeneration reinforcing bracket, such as Figure 1-2 As shown, it includes several pages, the length of each page is 3-7cm, the width is 0.1-0.5cm, and the thickness is 0.1-0.5mm; the side where the long side of each page is located is fixedly connected to form a central axis; each page It is sequentially divided into a first bone tunnel part 1 , a joint cavity part 2 and a second bone tunnel part 3 along the longitudinal direction.

[0034] As a preferred embodiment, the above-mentioned pagination is a three-dimensional porous structure, and the pagination of the three-dimensional porous structure is conducive to the migration of cells to the inside and the growth of blood vessels.

[0035] In this embodiment, the joint cavity 2 is loaded with an inducible regenerative active material, and the above-mentioned inducible regenerative active material is one or more of collagen, fibronectin, fibronectin, and proteoglycan; pref...

Embodiment 2

[0040] This embodiment provides the preparation method of the paginated ligament regeneration reinforcing scaffold in embodiment 1, including the following steps:

[0041] Step 1, using degradable polymers as raw materials, using electrospinning technology to prepare pages with a three-dimensional porous structure,

[0042] Step 2, each paged joint cavity part 2 is loaded with regenerative active substances, and the first bone tunnel part 1 and the second bone tunnel part 3 are loaded with cartilage-bone regeneration-promoting substances;

[0043] In step three, the pagination obtained in step two is fixedly connected through the weaving technique to obtain a pagination-type ligament regeneration reinforcing bracket.

[0044] Verification example 1

[0045] Paged ligament regeneration enhances the cell recruitment function of the scaffold in vitro:

[0046] The paginated ligament regeneration enhanced scaffold loaded with fibronectin in the joint cavity 2 was used as the exp...

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Abstract

The invention discloses a paging type ligament regeneration enhancing support and a preparation method thereof. The paging type ligament regeneration enhancing support comprises a plurality of pages,and the side face where the long edge of each page is located is fixedly connected to form a middle shaft; each page is sequentially divided into a first bone tunnel part, a joint cavity part and a second bone tunnel part in the long side direction. The paging type ligament regeneration enhancing support can enhance cell migration adhesion and blood vessel regeneration, promote ligament tissue regeneration and enhance tendon-bone interface regeneration in a bone canal, so that the clinical curative effect of a ligament graft for reconstructing an anterior cruciate ligament is improved, and theclinical requirement is very large.

Description

technical field [0001] The invention relates to the field of anterior cruciate ligament reconstruction, in particular to a paged ligament regeneration reinforcing bracket and a preparation method thereof. Background technique [0002] The incidence of anterior cruciate ligament injury is increasing year by year. Surgical reconstruction of the ACL is the mainstay of treatment due to the lack of blood vessels and cells in the ACL and insufficient self-regenerating potential. Clinically, autologous or allogeneic tendon grafts are often used to reconstruct the anterior cruciate ligament. Due to the biomechanical strength of the ACL, which is much stronger than other tendons or ligaments, when using tendons from other parts as ACL grafts, it often needs to be folded into multiple tendons (such as 4 strands or 8 strands) . Due to the void environment of the knee joint cavity, the anterior cruciate ligament has few sources of cells and blood vessels, which increases the difficul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/08
CPCA61F2/08A61F2002/0086
Inventor 赵金忠李亚民蒋佳蔡江瑜朱同贺
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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