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A kind of medicine for treating children's bronchial asthma and preparation method thereof

A technology for bronchial asthma and drugs, which is applied in the field of drugs for treating children with bronchial asthma and its preparation. It can solve the problems of uneven particle size, easy agglomeration of powder, insoluble budesonide, etc., and achieve uniform particle size and stability. Good results

Active Publication Date: 2022-04-15
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, budesonide has a technical problem of poor solubility. Combining the two into an inhaler has technical problems of uneven powder particle size and easy agglomeration of the powder during storage.

Method used

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  • A kind of medicine for treating children's bronchial asthma and preparation method thereof
  • A kind of medicine for treating children's bronchial asthma and preparation method thereof
  • A kind of medicine for treating children's bronchial asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dissolve albuterol: budesonide: polylactic acid: soybean lecithin in a molar ratio of 1:1:0.5:0.1 in an aqueous ethanol solution with a volume fraction of 90%, stir for 1 hour, and ultrasonicate for 1 hour at 40KHz and 40°C , and then through spray drying, the spray conditions are: dry gas: nitrogen, suction rate: 100%, inlet temperature: 60°C-90°C, outlet temperature: 40°C-50°C, cooling temperature: -17°C, feed rate : 5%-12% (1.5ml / min-3.6ml.min).

Embodiment 2

[0029] Dissolve albuterol: budesonide: polylactic acid: soybean lecithin in a molar ratio of 2:1:0.5:0.1 in an aqueous ethanol solution with a volume fraction of 90%, stir for 1 hour, and ultrasonicate for 1 hour at 40KHz and 40°C , and then through spray drying, the spray conditions are: dry gas: nitrogen, suction rate: 100%, inlet temperature: 60°C-90°C, outlet temperature: 40°C-50°C, cooling temperature: -17°C, feed rate : 5%-12% (1.5ml / min-3.6ml.min).

Embodiment 3

[0031] Dissolve albuterol: budesonide: soybean lecithin in a molar ratio of 1:1:0.1 in 90% ethanol aqueous solution, stir for 1 hour, and ultrasonicate for 1 hour at 40KHz and 40°C, then spray dry , The spray conditions are: dry gas: nitrogen, suction rate: 100%, inlet temperature: 60°C-90°C, outlet temperature: 40°C-50°C, cooling temperature: -17°C, feed rate: 5%-12 % (1.5ml / min-3.6ml.min).

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Abstract

The invention relates to a medicine for treating children's bronchial asthma, which is characterized in that it contains salbutamol, budesonide and soybean lecithin. In the present invention, by rationally designing the formula, the medicine for treating children's bronchial asthma has the advantages of good stability and uniform particle size, and the particle size distribution and average particle size meet the requirements of lung inhalation preparations.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a medicine for treating children's bronchial asthma and a preparation method thereof. Background technique [0002] Pediatric bronchial asthma, a heterogeneous disease characterized by chronic airway inflammation; with a history of respiratory symptoms of wheezing, shortness of breath, chest tightness, and cough, with variable expiratory airflow limitation, respiratory symptoms can vary in intensity and Varies over time. Asthma can occur at any age, and most of them begin before the age of 4 to 5. The vast majority of asthma is caused by respiratory tract infection. The symptoms are cough and wheeze in paroxysmal attacks, especially at night and early morning. Before the attack, there may be runny nose, sneezing and chest tightness. During the attack, it is difficult to breathe, and the expiratory phase is prolonged with wheezing. Severe cases s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K9/16A61K47/24A61K47/34A61K31/58A61K31/137A61P11/06
CPCA61K9/1617A61K9/1641A61K31/58A61K31/137A61P11/06A61K2300/00
Inventor 于斌赵青曾鹏周洁
Owner QINGDAO CENT HOSPITAL
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