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Ocular surface fluid collector and ocular surface disease diagnosis device

A technology of disease diagnosis and collector, which is applied in the direction of diagnosis, measuring device, inoculation and ovulation diagnosis, etc. It can solve the problems that the examiner is not easy to hold and operate, the patient's epithelial injury, and sampling failure, etc., and achieves high protein instant elution efficiency and solves the problem The effect of psychological tension and fast water absorption

Active Publication Date: 2021-04-06
智德明创生物科技(无锡)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current tear collection methods are mainly capillary method and filter paper adsorption method, etc., which have disadvantages such as long collection time and difficult elution of the adsorbed protein components.
Take the capillary method as an example: the shape and glass material of the glass capillary pipette make the patient easily nervous and unable to cooperate well with the examiner's operation, and the tip edge of the glass capillary pipette is relatively sharp, which may easily cause epithelial damage to the patient and cause sampling failure; , the glass capillary pipette is too thin, it is not easy for the inspector to hold and operate, etc.

Method used

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  • Ocular surface fluid collector and ocular surface disease diagnosis device
  • Ocular surface fluid collector and ocular surface disease diagnosis device
  • Ocular surface fluid collector and ocular surface disease diagnosis device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] This embodiment provides a kind of ocular surface fluid collector, and described ocular surface fluid collector comprises:

[0087] A collection rod, and a sampling material arranged at one end of the collection rod.

[0088] like figure 1 As shown, the collection rod in the ocular surface fluid collector provided in this embodiment includes a first collection rod 1 and a second collection rod 3 arranged in parallel, and an oblique arrangement between the first collection rod 1 and the second collection rod 3 The connecting rod 2.

[0089] Wherein, the first collecting rod 1 and the connecting rod 2, the connecting rod 2 and the second collecting rod 3 can be fixedly connected or hinged independently, as long as the connection angle between the first collecting rod 1 and the connecting rod 2 is greater than 90° and Just less than 180°.

[0090] When the first collecting rod 1 is fixedly connected with the connecting rod 2, preferably the connection angle between the ...

Embodiment 2

[0099] This embodiment provides a device for diagnosing ocular surface diseases.

[0100] like image 3 and Figure 4 As shown, the device for diagnosing ocular surface diseases provided in this embodiment includes an ocular surface fluid collector and a detection card used in conjunction with the ocular surface fluid collector.

[0101] Wherein, the ocular surface fluid collector may be the ocular surface fluid collector provided in Embodiment 1 of the present invention.

[0102] The detection card may include a casing 6 and a chromatography test strip 7 fixed in the casing.

[0103] In this embodiment, along the flow direction of the sample to be tested, the chromatographic test strip includes a sample pad 12 , a marking pad 13 , a cellulose membrane 14 and an absorbent paper 15 which are sequentially connected to the bottom plate 11 .

[0104] Wherein, the connection method with the base plate 11 can be a fixed connection, for example, the sample pad 12, the marker pad 13,...

Embodiment 3

[0111] This embodiment provides the preparation method of the detection reagent used in the chromatography test strip of the above-mentioned embodiment 2:

[0112] 1. Preparation of Tracer Antibody

[0113] The fluorescent microspheres were first diluted 10 times with ultrapure water, and the solid content was fixed at 0.1%. Ultrasonic dispersion was carried out for 5 minutes with an ultrasonic cleaner to obtain a suspension of fluorescent microspheres.

[0114] Weigh 50mg of N-hydroxysuccinimide (NHS) and dissolve it with 0.1M MES to prepare a solution (liquid A) with a concentration of 50mg / ml. Weigh 50mg of 1-(3-dimethylaminopropyl)- 3-Ethylcarbodiimide hydrochloride (EDC) was dissolved in 0.1M MES, prepared into a solution with a concentration of 50mg / ml (B solution), added to 10mL of fluorescent microsphere suspension and mixed, and then 0.4ml of Add liquid B into the suspension of fluorescent microspheres, mix well, and react at room temperature for 10 minutes; then cen...

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Abstract

The invention provides an ocular surface fluid collector and an ocular surface disease diagnosis device, which relate to the technical field of medical diagnostic reagents. The sampling material in the ocular surface fluid collector provided by the invention is used for direct contact and adsorption of ocular surface fluid. The sampling material with specific water absorption rate, specific water absorption speed and specific instant protein elution rate has the characteristics of high water absorption rate, fast water absorption speed, and high protein instant elution efficiency, which makes the ocular surface fluid collector convenient, simple and fast. The ocular surface fluid sample of the patient is collected, which solves the shortcomings of the prior art such as psychological stress in the collection process of the patient, difficulty in collection, and the like.

Description

technical field [0001] The invention relates to the technical field of medical diagnostic reagents, in particular to an ocular surface fluid collector and an ocular surface disease diagnosis device. Background technique [0002] Immunochromatography is a new type of immunoassay developed in the 1980s. Its main principle is to use nitrocellulose membrane as the carrier of solid phase chromatography, the substance to be detected is combined with the antibody labeled tracer particles (colloidal gold, latex microspheres, fluorescent microspheres, etc.) in advance, and then through capillary action Chromatography is carried out on a nitrocellulose membrane, and then the antigen or antibody pre-coated in the detection area of ​​the chromatographic membrane is combined to develop color. Compared with other detection methods, the biggest feature of immunochromatography technology is that it is simple and fast. The results generally do not require the aid of instruments and equipmen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B10/00G01N33/558G01N33/543G01N33/546G01N33/533
CPCA61B10/0045A61B2010/0067G01N33/533G01N33/54313G01N33/54346G01N33/558
Inventor 陶勇陆成慧常海涛付欣怡
Owner 智德明创生物科技(无锡)有限公司